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1.
BMC Pregnancy Childbirth ; 22(1): 157, 2022 Feb 25.
Artículo en Inglés | MEDLINE | ID: mdl-35216553

RESUMEN

BACKGROUND: The objective of the FeminFER project was to assess the value of ferric carboxymaltose following a multicriteria decision analysis in obstetrics and gynaecology in Spain. METHODS: Ferric carboxymaltose (FCM) and ferrous sulphate were evaluated using the EVIDEM framework. Ten stakeholders participated to collect different perspectives. The framework was adapted considering evidence retrieved with a PICO-S search strategy and grey literature. Criteria/subcriteria were weighted by level of relevance and an evidence-based decision-making exercise was developed in each criterion; weights and scores were combined to obtain the value of intervention relative to each criterion/subcriterion, that were further combined into the Modulated Relative Benefit-Risk Balance (MRBRB). RESULTS: The most important criterion favouring FCM was Compared Efficacy/Effectiveness (0.183 ± 0.07), followed by Patient Preferences (0.059 ± 0.10). Only Direct medical costs criterion favoured FS (-0.003 ± 0.03). MRBRB favoured FCM; 0.45 ± 0.19; in a scale from -1 to + 1. CONCLUSIONS: In conclusion, considering the several criteria involved in the decision-making process, participants agreed with the use of FCM according to its MRBRB.


Asunto(s)
Anemia Ferropénica/tratamiento farmacológico , Técnicas de Apoyo para la Decisión , Compuestos Férricos/uso terapéutico , Compuestos Ferrosos/uso terapéutico , Maltosa/análogos & derivados , Complicaciones Hematológicas del Embarazo/tratamiento farmacológico , Femenino , Humanos , Maltosa/uso terapéutico , Embarazo , Medición de Riesgo , España/epidemiología , Participación de los Interesados
2.
Minerva Anestesiol ; 87(12): 1290-1299, 2021 12.
Artículo en Inglés | MEDLINE | ID: mdl-34337914

RESUMEN

BACKGROUND: Recent investigations have showed that cesarean section (CS) might be a cause of chronic pain, with a consequent decrease in quality of life. METHODS: Prospective observational study in a Spanish tertiary hospital. Main outcome measure was to assess early neuropathic characteristics of pain (DN2 score ≥3) one week after CS as a potential risk factor for post-cesarean section chronic pain (PCSCP) at three months. Secondary outcome was to identify other risk factors. Six hundred ten consecutive consenting patients undergoing CS were interviewed preoperatively, at discharge from recovery room and 24 hours postoperatively. Telephone follow-up interviews were conducted one week, three months and twelve months following surgery. RESULTS: We analyzed 597 consecutive patients. The incidence of PCSCP at three and twelve postoperative months were 6.2% and 1% respectively. Subjects with NRS score superior to five on movement one week after CS presented higher incidence of PCSCP (NRS superior to five: 19 [52.2%]; NRS equal or lower to five: 172 [30.9%]; P=0.009). On multivariate analysis neuropathic pain one week after CS was associated with a higher risk of PCSCP (AOR=1.63 [95% CI: 1.26-2.11; P<0.001]). Other identified risk factors for PCSCP were: uterine exteriorization during CS (AOR=3.89 [95% CI: 1.25-12.10; P=0.019]) and a lower gestational age (AOR=0.87 [95% CI: 0.78-0.96; P=0.008]). CONCLUSIONS: Incidence of PCSCP at three and twelve postoperative months was low, 6.2% and 1% respectively. Early neuropathic characteristics of pain after one week measured by neuropathic pain questionnaire, consisting of two questions (DN2)≥3/7 could be used to identify patients at risk for chronic post-surgical pain and develop preventive strategies.


Asunto(s)
Dolor Crónico , Cesárea , Dolor Crónico/epidemiología , Femenino , Humanos , Dolor Postoperatorio/epidemiología , Embarazo , Estudios Prospectivos , Calidad de Vida
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