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1.
J Am Podiatr Med Assoc ; 111(2)2021 Mar 01.
Artículo en Inglés | MEDLINE | ID: mdl-31549854

RESUMEN

BACKGROUND: A survey of pathology present in the subtalar joint by means of subtalar arthroscopy with anterolateral and middle portals has not been extensively explored in the literature. The focus of this study was to identify pathology in the subtalar joint with subtalar joint arthroscopy using this approach. We also compared these arthroscopic findings with those reported in the literature. METHODS: We performed a retrospective review of 49 consecutive patients who had undergone 53 subtalar arthroscopic procedures. Data were obtained from intraoperative arthroscopic findings that were documented in the operative note or with arthroscopic photography. Additional procedures, including ankle arthroscopy, lateral ankle stabilization, and peroneal tendon repair, were recorded. Descriptive statistics were calculated and reported. RESULTS: Subtalar arthroscopic examination revealed that all of the patients had intra-articular synovitis or adhesions present. Twenty-two procedures (42%) demonstrated subtalar joint instability, seven (13%) revealed chondromalacia, and one (2%) had an exostosis present. These observations are consistent with other reported findings in the literature. CONCLUSIONS: This study found that the subtalar joint was most often affected by synovitis, adhesions, and instability in patients with symptomatic pathologies requiring subtalar arthroscopy. There was a relatively low incidence of chondromalacia or exostosis formation in the survey.


Asunto(s)
Neoplasias Óseas , Articulación Talocalcánea , Articulación del Tobillo , Artroscopía , Humanos , Estudios Retrospectivos , Articulación Talocalcánea/cirugía
2.
Diabet Foot Ankle ; 10(1): 1579631, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30815231

RESUMEN

Background: Foot complications such as ulceration and neuropathy are common complications of diabetes mellitus (DM). Previous reports have demonstrated a possible increased risk of these complications in diabetic patients with low levels of serum vitamin D.Objectctive: The purpose of this study is to compare serum vitamin D levels in diabetic patients with and without Charcot neuroarthropathy (CN), peripheral arterial disease (PAD), infection (DFI), ulceration (DFU), and peripheral neuropathy (DPN). Design: A retrospective chart review of all patients undergoing foot and ankle surgery with a history of DM over a 13 month period was performed. From this cohort, fifty subjects with CN were matched with 50 without CN and preoperative lab values were compared. A secondary evaluation was performed on the subjects' other comorbidities including PAD, DFI, DFU, and DPN. Results: Seventy-eight percent of our patients had vitamin D deficiency or insufficiency. Preoperative serum vitamin D levels were not significantly different between diabetic patients with and without CN (p = 0.55). Diabetic patients with PAD (p = 0.03), DFI (p = 0.0006), and DFU (p = 0.04) were all found to have significantly lower serum vitamin D levels than diabetic patients without these complications. Lower levels of serum albumin and higher serum creatinine were also noted with subjects with PAD, DFI, DPN, and DFU. While seasonal serum vitamin D level fluctuation was noted, this difference did not reach statistical significance with the numbers available. Conclusion: We found various lower extremity complications to be associated with low serum vitamin D including PAD, DFI, and DFU. While other studies have questioned the role of vitamin D and CN, we were unable to identify any significant difference between diabetic patients with and without Charcot neuroarthropathy. Level of evidence: Level 2.

3.
Foot Ankle Spec ; 8(4): 260-5, 2015 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-25389232

RESUMEN

INTRODUCTION: Many surgeries exist for treatment of insertional Achilles tendinopathy. Another surgical option to consider is an isolated gastrocnemius recession. Recent studies have demonstrated the success of a gastrocnemius recession for noninsertional Achilles tendinitis. We hypothesize that an isolated gastrocnemius recession can be a successful, effective, and less invasive surgery for patients with chronic insertional Achilles tendinopathy. MATERIALS AND METHODS: This article presents a retrospective review of one surgeon's results of 11 patients (2010-2012), with an average age of 59 years who presented with chronic insertional Achilles tendinopathy. Gastrocnemius recessions, either endoscopic or open, were performed after an average of 6.2 months of conservative treatment. All patients' radiographs were reviewed preoperatively for any calcaneal spurs and divided into groups accordingly. Average follow-up time postoperatively was 13.8 months. Plantarflexion strength, equinus deformity, as well as the American Orthopaedic Foot and Ankle Society (AOFAS) hindfoot instrument was assessed. RESULTS: In all, 10/11 (91%) patients had high patient satisfaction, pain relief, no residual equinus deformity, loss in muscle strength and returned to regular activities successfully at 1-year follow up. All patients and groups had significant improvement in AOFAS scores. The median postoperative AOFAS score was 94.8. All patients and patient groups had significant improvement pre- to postoperatively. Patients without spurs appear to do better than patients with spurs. One patient developed recurrence of insertional heel pain and equinus deformity. Other complications included 2 sural nerve parasthesias, which resolved. CONCLUSION: An isolated gastrocnemius recession for chronic insertional Achilles tendinopathy can provide high satisfaction, pain relief, and a faster recovery period with few or no complications. LEVELS OF EVIDENCE: Therapeutic, Level IV: Case series.


Asunto(s)
Tendón Calcáneo/cirugía , Endoscopía/métodos , Músculo Esquelético/cirugía , Procedimientos Ortopédicos/métodos , Satisfacción del Paciente , Adulto , Anciano , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Proyectos Piloto , Estudios Retrospectivos , Tendinopatía , Resultado del Tratamiento
4.
Foot Ankle Spec ; 6(2): 119-24, 2013 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-23349382

RESUMEN

INTRODUCTION: Lawn mower injuries occur frequently in the United States and oftentimes result in extensive trauma to the lower extremities. These injuries can be quite devastating and cause there to be loss of function and amputation. The purpose of this study was to determine if there are specific factors that would help determine the best treatment protocol, patient outcomes, and prognosis after lawn mower injury to the foot and ankle. MATERIAL AND METHODS: A retrospective review of medical records was performed on all patients treated at a university level 1 trauma center from 2000 to 2010. Only subjects 18 years or older who sustained an injury below the level of the knee were included for review. RESULTS: Seventy-three patients were included in this review. The results revealed that patients who developed a complication were significantly older than the group of patients without complications (P = .03). Digits were found to be injured most often but the odds of developing a complication were much higher if these injuries involved the plantar foot, dorsal foot, or ankle. Interestingly, patients on prolonged antibiotic therapy had a significantly higher risk of developing complications. The presence of comorbidities significantly increased the risk of complication (P = .008); the greatest risk factors were cardiovascular disease (P = .001) and diabetes (P = .06). DISCUSSION: The authors present the largest cohort of lawn mower injuries in the medical literature, which demonstrates that factors such as age, location of injury, and the presence of comorbidities influence the outcome and increase the risk of injury to the foot and ankle. These results may be useful in determining the best treatment plan possible for patients with these severe injuries. LEVELS OF EVIDENCE: Therapeutic, Level IV, Retrospective case series.


Asunto(s)
Accidentes Domésticos/estadística & datos numéricos , Traumatismos de los Pies/epidemiología , Artículos Domésticos , Adulto , Amputación Quirúrgica/estadística & datos numéricos , Femenino , Traumatismos de los Pies/etiología , Traumatismos de los Pies/cirugía , Humanos , Masculino , Persona de Mediana Edad , Procedimientos de Cirugía Plástica/métodos , Estudios Retrospectivos , Factores de Riesgo , Índices de Gravedad del Trauma , Estados Unidos/epidemiología
5.
Foot Ankle Spec ; 6(3): 185-90, 2013 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-23349381

RESUMEN

INTRODUCTION: Insertional Achilles tendinopathy is a problem frequently encountered by the foot and ankle surgeon. Conservative care yields mixed results, and this condition is often treated surgically. Our hypothesis is that the suture bridge technique through a central posterior incision allows adequate visualization for thorough debridement and exostectomy and provides a stable tendon-to-bone interface for healing. MATERIAL AND METHODS: The medical records of 35 patients who underwent surgical treatment for insertional Achilles tendinopathy with the suture bridge technique, by a single surgeon, between 2006 and 2012 were retrospectively reviewed. American Orthopaedic Foot and Ankle Society (AOFAS) hindfoot instruments as well as a subjective questionnaire were utilized. RESULTS: In all, 30 individuals who met the inclusion criteria for the treatment of insertional Achilles tendinopathy were evaluated at a mean follow-up of 28.93 ± 16.99 months. We included 10 men and 20 women, with a mean age of 49.1 ± 9.2 years. The mean preoperative AOFAS score was 56.6 ± 14.0. The average postoperative AOFAS score significantly increased to 91.7 ± 10.4 (P < .0001). One participant required revisional surgery, consisting of a flexor hallucis longus transfer performed by another physician. There were no wound complications or infections. Overall, there was a 97% (28/29) satisfaction rate. CONCLUSION: The central incision with complete detachment of the Achilles tendon and reattachment with the suture bridge technique for the treatment of insertional Achilles tendinopathy provides an effective treatment with good to excellent clinical outcomes in 97% of patients, with a mean follow-up of 29 months.


Asunto(s)
Tendón Calcáneo/cirugía , Técnicas de Sutura , Tendinopatía/cirugía , Tendón Calcáneo/lesiones , Femenino , Humanos , Masculino , Persona de Mediana Edad , Reoperación/estadística & datos numéricos , Estudios Retrospectivos , Encuestas y Cuestionarios , Resultado del Tratamiento
6.
Clin Podiatr Med Surg ; 29(3): 413-24, 2012 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-22727381

RESUMEN

Contracture of the Achilles-gastrocnemius-soleus complex leading to ankle equinus has been linked to the development of various foot disorders. Decrease in ankle dorsiflexion results in an increase in plantar pressures and in diabetes and neuropathy, increased pressures can lead to ulceration and possibly the formation of Charcot foot. Surgical management of the equinus deformity corrects this abnormality and has the potential to avert the development of Charcot foot or ankle. Gastrocnemius recession, tendo-Achilles lengthening, and Achilles tenotomy have all been offered as surgical solutions to this condition. This article reviews ankle equinus and compares the treatment options available. A video of Hoke's triple hemisection has been included with this article and can be viewed at www.podiatric.theclinics.com.


Asunto(s)
Tendón Calcáneo/cirugía , Pie Diabético/complicaciones , Pie Equino/cirugía , Músculo Esquelético/cirugía , Tenotomía/métodos , Contractura/cirugía , Pie Equino/etiología , Pie Equino/patología , Humanos , Procedimientos Ortopédicos/efectos adversos , Procedimientos Ortopédicos/instrumentación , Procedimientos Ortopédicos/métodos , Selección de Paciente , Tenotomía/efectos adversos , Tenotomía/instrumentación , Resultado del Tratamiento
7.
J Am Podiatr Med Assoc ; 102(3): 213-22, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-22659764

RESUMEN

BACKGROUND: This prospective study was performed to compare calcaneal and lumbar bone mineral density (BMD) in individuals with and without diabetes mellitus. We compared bone density with the time from onset of Charcot's neuroarthropathy (CN) in patients with unilateral, nonoperative, reconstructive-stage CN. The final purpose was to investigate the role that sex, age, and serum vitamin D level may have in osseous recovery. METHODS: Thirty-three individuals were divided into three groups: controls and patients with diabetes mellitus with and without CN. Peripheral instantaneous x-ray imaging and dual-energy x-ray absorptiometry were performed. RESULTS: The calcaneal BMD of patients with diabetes mellitus and CN was lower than that of the control group (P < .01) but was not significantly lower than that of patients with diabetes mellitus alone. There was no statistically significant difference in lumbar T-scores between groups. Women demonstrated lower BMD than did men (P = .02), but patients 60 years and older did not demonstrate significantly lower BMD than did patients younger than 60 years (P = .135). A negative linear relationship was demonstrated between time and BMD in patients with CN. CONCLUSIONS: The results of this study suggest that lumbar BMD does not reflect peripheral BMD in patients with diabetes mellitus and reconstructive-stage CN. This study has clinical implications when reconstructive osseous surgery is planned in patients with CN.


Asunto(s)
Artropatía Neurógena/fisiopatología , Densidad Ósea/fisiología , Calcáneo/diagnóstico por imagen , Neuropatías Diabéticas/fisiopatología , Vértebras Lumbares/diagnóstico por imagen , Absorciometría de Fotón , Adulto , Anciano , Estudios de Casos y Controles , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Vitamina D/sangre
8.
Foot Ankle Spec ; 5(3): 180-4, 2012 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-22441501

RESUMEN

INTRODUCTION: Atraumatic avascular necrosis (AVN) is an unusual pathology to the foot. Risk factors include the use of corticosteroids, smoking, alcohol, rheumatologic disorders, hematologic disorders, and metabolic disorders. To the authors' knowledge, this study presents the first case of bilateral atraumatic AVN to the navicular and medial cuneiform in a patient with systemic lupus erythamatosus (SLE). CASE DESCRIPTION: A 40-year-old man presented with a past medical history of SLE in which he developed AVN of the tarsal navicular and medial cuneiform. This occurred first on the subject's right foot and then while recovering from surgical intervention, on his left foot. Talonaviculocuneiform arthrodesis was performed with the use of distal tibial autograft on both extremities. The subject's American Orthopaedic Foot and Ankle Society midfoot score improved from 34 to 80 at 21 months on the right and 37 to 90 at 15 months to the left. DISCUSSION: Patients with SLE carry a significant risk of developing AVN. Comorbidities such as vasculitis, corticosteroid use, cytotoxic medication, and peripheral neuropathy are known risk factors in the development of AVN. Unusual features such as multifocal AVN and unusual anatomic locations can occur with SLE. AVN of the foot is generally treated with surgical intervention. Treatments such as core decompression, open reduction and internal fixation, and arthrodesis have been recommended based on the symptoms and presentation. CONCLUSION: The authors present a very rare presentation of bilateral osteonecrosis of the tarsal navicular and first cuneiform in a patient with SLE. The patient was treated with bilateral talonaviculocuneiform arthrodesis. The patient demonstrated considerable improvement to both extremities. LEVELS OF EVIDENCE: Therapeutic, Level IV.


Asunto(s)
Lupus Eritematoso Sistémico/complicaciones , Osteonecrosis/diagnóstico , Huesos Tarsianos/patología , Adulto , Artrodesis , Humanos , Imagen por Resonancia Magnética , Masculino , Osteonecrosis/cirugía , Dolor/etiología , Huesos Tarsianos/cirugía , Articulaciones Tarsianas/cirugía
9.
J Foot Ankle Surg ; 51(1): 123-7, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-22055492

RESUMEN

Avulsion fractures of the calcaneal tuberosity represent only 1.3% to 2.7% of calcaneal fractures. These fractures are common pathologically in nature and attributed to decreased bone mineral density. Calcaneal insufficiency avulsion (CIA) fracture in patients with diabetes mellitus is most likely due to Charcot neuroarthropathy (CN) as described by the Brodsky classification (Brodsky 3B). Traditional open reduction and internal fixation is difficult in all calcaneal avulsion fractures because of poor bone quality. The authors report the first known description of the use of fracture fragment excision and double row anchor fixation.A 39-year-old woman with type I diabetes mellitus and a history of CN presented with an avulsion fracture of the calcaneal tuberosity. Excision of the fracture fragment and a gastrocnemius recession and reattachment of the Achilles tendon with double row anchor fixation to the calcaneus were performed. At 1 year, the patient's American Orthopaedic Foot & Ankle Society rearfoot score improved from 27/100 to 88/100. CIA fractures are an infrequently described injury. Because diabetes mellitus is frequently associated with this disease, it most likely represents a CN event. Traditionally, CIA fractures have been operatively treated with open reduction internal fixation. Previous authors have described difficulty with fixation because of poor quality. In the current report, the authors describe a novel operative approach to CIA fractures through the use of double row anchor fixation and excision of the fracture fragments. The authors feel that this previously undescribed treatment is superior to traditional methods and may serve as a new treatment option for all patients who have sustained this unusual pathology regardless of the underlying cause. The current authors provide a novel operative technique that provides inherent advantages to the traditional repair of CIA fractures. We believe CIA fractures represent a CN-type event and care should be taken when evaluating and treating these patients to prevent further sequelae.


Asunto(s)
Artropatía Neurógena/etiología , Calcáneo/cirugía , Diabetes Mellitus Tipo 1/complicaciones , Fijación de Fractura/métodos , Fracturas Espontáneas/cirugía , Anclas para Sutura , Tendón Calcáneo/cirugía , Adulto , Artropatía Neurógena/cirugía , Calcáneo/lesiones , Femenino , Fracturas Conminutas/etiología , Fracturas Conminutas/cirugía , Fracturas Espontáneas/etiología , Humanos , Músculo Esquelético/cirugía
10.
Clin Podiatr Med Surg ; 28(4): 607-18, 2011 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-21944395

RESUMEN

Internal fixation has become a pillar of surgical specialties, yet the evolution of these devices has been relatively short. The first known description of medical management of a fracture was found in the Edwin Smith Papyrus of Ancient Egypt (circa 2600 bc). The first description of internal fixation in the medical literature was in the 18th century. The advancement of techniques and technology over the last 150 years has helped to preserve both life and function. The pace of advancement continues to accelerate as surgeons continue to seek new technology for osseous fixation. The authors present a thorough review of the history of internal fixation and the transformation into a multibillion dollar industry.


Asunto(s)
Fijación Interna de Fracturas/historia , Fenómenos Biomecánicos , Ingeniería Biomédica , Fijación Interna de Fracturas/instrumentación , Historia del Siglo XVIII , Historia del Siglo XIX , Historia del Siglo XX , Historia del Siglo XXI , Humanos , Industrias/historia , Industrias/estadística & datos numéricos , Metalurgia/historia , Dispositivos de Fijación Ortopédica/historia , Diseño de Prótesis , Suturas
11.
Foot Ankle Spec ; 4(6): 361-9, 2011 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-21926359

RESUMEN

UNLABELLED: There is no consensus on the optimal incisional approach at the posterior leg to avoid wound healing complications. The purpose of this systematic review is to report and compare complication rates associated with two common incisions used to approach the Achilles tendon in order to provide additional recommendations for optimal incision placement. MATERIALS AND METHODS: Four electronic databases were searched using keywords for procedures using posterior leg incisions. A total of 8724 studies were analyzed and subjected to inclusion and exclusion criteria. Once inclusion criteria were met, each article was placed in 1 of 2 groups based on incision placement: midline (group 1) or posterior medial (group 2). Study format, patient demographics, surgical indication and other details, and wound complications were recorded. The data obtained was reviewed for trends between the two groups. RESULTS: 38 articles met the inclusion criteria. Seven articles used the midline approach (group 1) whereas 31 articles used the posterior medial incision (group 2). The 38 articles included 1287 patients, of whom 25.6% were female with an average age of 43.9 years. Group 1 included 142 patients and group 2 had 1145 patients. The total wound complication rate among all reports was determined to be 8.2%, with 7.0% and 8.3% between groups 1 and 2, respectively. DISCUSSION: Although incision placement may influence wound healing complications, it appears that additional factors such as advanced age, delay in surgical intervention, gender, comorbid conditions, prior surgery, and postoperative protocols also play a role. This report suggests that a midline approach is no less precarious in avoidance of wound complications regardless of patient demographics or other surgical details in comparison with a posterior medial incision. LEVEL OF EVIDENCE: Therapeutic, Level IV.


Asunto(s)
Tendón Calcáneo/cirugía , Pierna/cirugía , Infección de la Herida Quirúrgica/etiología , Cicatrización de Heridas , Factores de Edad , Comorbilidad , Humanos , Cuidados Posoperatorios , Factores Sexuales
12.
J Foot Ankle Surg ; 49(6): 566-70, 2010.
Artículo en Inglés | MEDLINE | ID: mdl-20801690

RESUMEN

A wide range of techniques have been described for ankle arthrodesis, and although all of these have been shown to provide stability, few have been shown to achieve a solid construct in patients at risk of nonunion. In this technical guide, we describe a modified transfibular approach to ankle arthrodesis that uses a fibular-onlay strut graft for use in patients at high risk for nonunion. In our experience, the technique has been effective and reliable.


Asunto(s)
Articulación del Tobillo/cirugía , Artrodesis/métodos , Peroné/trasplante , Tornillos Óseos , Humanos , Osteotomía
13.
Foot Ankle Spec ; 3(1): 21-8, 2010 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-20400436

RESUMEN

Tobacco cigarette smoking causes many negative effects on the body, and it is the leading preventable cause of death in the United States. These negative effects are a concern for the foot and ankle surgeon, as smoking can increase the risk of diabetes and peripheral artery disease and delay healing of surgical incisions and ulcerations of the lower extremities. Tobacco cigarette smoking can also increase the risk of avascular necrosis and delayed union and nonunions of fractures and osteotomies. Smoking cessation is an important component in the overall treatment of conditions affecting the foot and ankle. Smoking cessation can be a difficult goal to achieve, but proper education and support can help patients reach this goal.


Asunto(s)
Extremidad Inferior/cirugía , Educación del Paciente como Asunto , Cese del Hábito de Fumar , Tabaquismo/complicaciones , Amputación Quirúrgica , Fracturas Óseas/etiología , Fracturas Óseas/cirugía , Humanos , Extremidad Inferior/fisiopatología , Osteonecrosis/etiología , Osteonecrosis/cirugía , Enfermedades Vasculares Periféricas/etiología , Relaciones Médico-Paciente , Astrágalo/lesiones , Cicatrización de Heridas/fisiología
14.
J Foot Ankle Surg ; 49(2): 159.e9-13, 2010.
Artículo en Inglés | MEDLINE | ID: mdl-20137982

RESUMEN

The gastrocnemius recession is a popular surgical procedure for the treatment of equinus contracture. Lengthening the gastrocnemius tendon has been show to be an effective means of reducing pressure to the plantar forefoot by weakening the triceps surae complex. The more traditional method of weakening the triceps surae is a modification of Hoke's triple hemisection through the tendoAchillis. This technique unfortunately carries a serious risk of the development of a calcaneal gait. The purpose of this case report is to demonstrate that the gastrocnemius recession is an effective and safe alternative to the traditional tendoAchillis lengthening. The authors also describe a minimally invasive technique that uses a pediatric speculum for a self-retrained retractor and portal for instrumentation and visualization.


Asunto(s)
Tendón Calcáneo/cirugía , Úlcera del Pie/cirugía , Antepié Humano/fisiopatología , Músculo Esquelético/cirugía , Enfermedades del Sistema Nervioso Periférico/complicaciones , Úlcera del Pie/complicaciones , Úlcera del Pie/fisiopatología , Humanos , Pierna , Masculino , Persona de Mediana Edad , Enfermedades del Sistema Nervioso Periférico/fisiopatología , Presión , Cicatrización de Heridas
15.
J Am Podiatr Med Assoc ; 99(1): 35-41, 2009.
Artículo en Inglés | MEDLINE | ID: mdl-19141720

RESUMEN

BACKGROUND: This study was designed to compare the vitamin D levels in a cohort of nondiabetic patients to populations of diabetic patients with and without Charcot neuroarthropathy. METHODS: A total of 41 participants (22 male, 19 female) with a mean +/- SD age of 59 +/- 9.43 years had serum 25-hydroxyvitamin D levels tested. Fifteen participants composed the nondiabetic group; 13, the group with diabetes but without Charcot neuroarthropathy; and 13, the group with both diabetes and Charcot neuroarthropathy. RESULTS: The results of the study showed that the vitamin D levels in both diabetic populations were significantly lower (P < .05) than the nondiabetic population. There was no statistical difference between the group with diabetes but without Charcot foot disease and the group with both diabetes and Charcot neuroarthropathy. CONCLUSIONS: Based on the results of this study, given the importance of vitamin D in bone metabolism and the osseous consequences associated with diabetes, as well as other systems affected by low levels of vitamin D in the diabetic patient, it appears that vitamin D levels should be monitored in diabetic patients.


Asunto(s)
Diabetes Mellitus/sangre , Vitamina D/análogos & derivados , Adulto , Anciano , Artropatía Neurógena/sangre , Diabetes Mellitus/metabolismo , Femenino , Humanos , Masculino , Persona de Mediana Edad , Vitamina D/sangre , Vitamina D/metabolismo , Deficiencia de Vitamina D/complicaciones
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