RESUMEN
Patients with 47, XXY karyotype (Klinefelter syndrome) appear to have increased risk of developing cancer, especially male breast cancer, germ cell tumours and non Hodgkin lymphomas, but rarely acute myeloid leukaemia. We report a patient with acute basophilic leukaemia with 47, XXY karyotype in both the tumour and constitutional cells. Acute basophilic leukaemia is very rare disease comprising less than 1% of all acute myeloid leukaemias. Morphological characteristic of leukaemic blast cells is moderately basophilic cytoplasm containing a variable number of coarse basophilic granules. The most characteristic cytochemical reaction is metachromatic positivity with toluidine blue. Blast are myeloperoxidase negative. Also leukemic blasts express myeloid and monocyte markers. There is no consistent chromosomal abnormality identified in this leukaemia. This is the first reported case of acute basophilic leukaemia in patient with Klinefelter syndrome. In this article the medical history of the patient is given and the possible connection between Klinefelter syndrome and acute myeloid leukaemia is discussed.
Asunto(s)
Síndrome de Klinefelter/complicaciones , Leucemia Basofílica Aguda/complicaciones , Crisis Blástica , Células de la Médula Ósea/patología , Aberraciones Cromosómicas , Mapeo Cromosómico , Resultado Fatal , Humanos , Cariotipificación , Síndrome de Klinefelter/genética , Síndrome de Klinefelter/patología , Leucemia Basofílica Aguda/genética , Leucemia Basofílica Aguda/patología , Masculino , Persona de Mediana Edad , Insuficiencia Multiorgánica/patologíaRESUMEN
In 14 patients with different stages of cervical dysplasia laser vapourization was performed. Patients were between 25 and 44 year old (mean 35). Gynaecological history included 0-2 deliveries (mean 1.5). The procedure is minimally invasive after which complete cervical restitution is achieved. Control PAPA smear taken after 2 months, 6 months and one year respectively showed maximal therapeutic success. No complications were observed. The procedure is recommended for young women planning childbirth.