[Correction of neurovegetative and psychoemotional disorders in patients with post-castration syndrome by non-drug means]. / Korrektsiya neirovegetativnykh i psikhoemotsional'nykh narushenii u patsientok s postkastratsionnym sindromom nemedikamentoznymi sredstvami.

Due to decrease in life quality of gynecological oncology patients after completed radical antitumor treatment because of chemotherapy and radiation therapy consequences, pre- and postoperative stress, the development of post-castration syndrome, the problem of this contingent rehabilitation remains important. The methods of non-drug therapy, in particular, physical factors that have a multifaceted effect on the body and increase its resistance to adverse conditions are of interest. These factors include normobaric hypoxia which improves oxygen transport and tissue respiration, enhances detoxification processes, increases mental and physical performance, and increases the body's nonspecific resistance. EHF-therapy promotes the implementation of anti-stress reactions, normalizes the activity of the sympathoadrenal link of the autonomic nervous system. It is assumed that the complex use of normobaric hypoxia and EHF-therapy would reduce the negative consequences of antitumor treatment and lead to positive dynamics of the post-castration syndrome clinical picture. OBJECTIVE: To study the dynamics of neurovegetative and psychoemotional disorders during rehabilitation in patients with post-castration syndrome after completed radical antitumor treatment for cervical cancer or uterine body cancer Ib-IIb stages. MATERIAL AND METHODS: 106 patients with post-castration syndrome developed after radical antitumor treatment for cervical cancer or uterine body cancer stage Ib-IIb were examined. The main group consisted of 66 patients who received the author's rehabilitation program which included normobaric hypoxia procedures, EHF-therapy and water aerobics 6-12 months after the completed radical antitumor treatment. The control group consisted of 40 patients were examined according to the protocol at the same time but they were not assigned a course of rehabilitation. RESULTS: After the completed radical antitumor treatment (6-12 months) the neurovegetative and psychoemotional disorders including anxiety and depression persisted. After patients' rehabilitation the severity of clinical symptoms of post-castration syndrome decreased; that was accompanied by positive dynamics of neurovegetative (p<0.01) and psychoemotional (p<0.01) symptoms (Kupperman scale), indicators of anxiety (p<0.01) and depression (p<0.05) (HADS scale), situational anxiety (p<0.01) (Spielberger-Khanin scale), the severity of mental and somatic signs of anxiety by 51.0% (Hamilton scale). CONCLUSION: The proposed rehabilitation complex helps to reduce the functional tension of the higher nervous system autonomic centers and to increase the nonspecific body reactivity. This allows to recommend the proposed course for the rehabilitation of this patients' category.

Role of JNK and Involvement of p53 in Stimulation of Growth Potential Realization of Mesenchymal Precursor Cells by Alkaloid Songorine.

The role of JNK-mediated signal pathway and participation of p53 transcription factor in stimulation of realization of the growth potential of the mesenchymal precursor cells by alkaloid songorine were examined in vitro. Specific inhibitors of JNK and p53 enhanced stimulation of fibroblast colony/cluster formation and proliferative activity of mesenchymal precursor cells. Under these conditions, more pronounced effects were observed with early precursors of fibroblast CFU and in both cases were accompanied by a decrease in differentiation index of progenitor elements.

Pecularities of prolonged use of moxonidine in patients with hypertension associated with metabolic syndrome.

A 6-month clinical study with active therapeutic intervention was carried out to evaluate the efficacy of moxonidine for the correction of arterial hypertension in 30 patients with metabolic syndrome. Along with the metabolic neutrality for the lipid and purine metabolism, the drug demonstrated a distinct antihypertensive effect, which against the background of pronounced sympatholytic action after 3 months of therapy tends to disappear, which can be prevented by dosage correction. It was shown that the efficacy of moxonidine in reducing insulin resistance in patients with metabolic syndrome directly depends on the severity of hypersympathicotonia manifesting in heart rate over 80 bpm at rest.

[EHF-therapy and IR radiation in combined treatment of children suffering from atopic dermatitis].

One hundred and 30 patients with atopic dermatitis were divided into three groups. The patients of group 1 (50 children) received EHF-IR therapy on biologically active points, the patients of group 2 (50 children) received EHF therapy alone, 30 children of group 3 received only chemotherapy. A comparison of the three methods of atopic dermatitis treatment revealed that EHF-IR therapy is superior to the rest treatments by both short- and long-term treatment outcomes.

[The anti-arrhythmic effect of the electrophoresis of a natural shirsal preparation in the 2nd-stage rehabilitation of myocardial infarct patients]. / Antiaritmicheskii éffekt élektroforeza prirodnogo preparata shirsala na II étape reabilitatsii bol'nykh infarktom miokarda.

Experimental and clinical trials of antiarrhythmic effect of shirsal (natural salt of lake Shira mineral water) have shown that rehabilitation complex including shirsal electrophoresis is beneficial for MI patients with arrhythmia. Shirsal electrophoresis extends indications for sanatorium treatment of MI patients with stable angina of effort (functional class III-IV), grade I-IV arrhythmia, chronic circulatory insufficiency.