RESUMEN
Electrochromic optical recording (ECORE) is a label-free method that utilizes electrochromism to optically detect electrical signals in biological cells with a high signal-to-noise ratio and is suitable for long-term recording. However, ECORE usually requires a large and intricate optical setup, making it relatively difficult to transport and to study specimens on a large scale. Here, we present a Compact ECORE (CECORE) apparatus that drastically reduces the spatial footprint and complexity of the ECORE setup whilst maintaining high sensitivity. An autobalancing differential photodetector automates common-mode noise rejection, removing the need for manually adjustable optics, and a compact laser module conserves space compared to a typical laser mount. The result is a simple, easy-to-use, and relatively low cost system that achieves a sensitivity of 16.7 µV (within a factor of 5 of the shot noise limit), and reliably detects action potentials from Human-induced pluripotent stem cell (HiPSC) derived cardiomyocytes. This setup can be further improved to within 1.5 dB of the shot noise limit by filtering out power-line interference.
RESUMEN
Nonreciprocal optical systems have found many applications altering the linear transmission of light as a function of its propagation direction. Here, we consider a new class of nonreciprocity which appears in photon pair correlations and not in linear transmission. We experimentally demonstrate and theoretically verify this nonreciprocity in the second-order coherence functions of photon pairs produced by spontaneous four-wave mixing in a silicon microdisk. Reversal of the pump propagation direction can result in substantial extinction of the coherence functions without altering pump transmission.
