[Clinical effect and tolerance of paxil (paroxetine) in management of panic disorders]. / Klinicheskaia éffektivnost' i perenosimost' paksila (paroksetina) pri lechenii panicheskogo rasstroistva.

AIM: To determine clinical efficiency and tolerance of paxil (paroxetin) in the treatment of panic disorders. MATERIAL AND METHODS: An open, non-comparative 7 week study entered 60 patients (mean age 36.6 +/- 3.22 years) with panic disorders and agoraphobias with panic disorders. Paroxetin was given in a single daily dose 20-60 mg/day in the morning. The results were assessed by Hamilton and Sihan scales, scale of clinical impression, by reduction of panic attacks. RESULTS: In 72.2% of patients panic attacks ceased or occurred less frequently (by 50%). Anxiety relieved by 67 +/- 4.6%. The number of the responders was greater while the effect occurred faster in patients with panic disorders. The drug was well tolerated, side effects occurred in 43.3% of cases. They were mild or moderate. CONCLUSION: Paroxetin has a prominent anxiolytic and antiphobic action, is well tolerated and is effective in panic disorders and agoraphobia with panic disorders.

[Insulin sensitivity during use of adrenoblockers and adrenomimetics]. / Izuchenie chuvstvitel'nosti k insulinu pri primenenii adrenoblokatorov i adrenomimetikov.

The effect of adrenergic blocking agents and adrenomimetics on sensitivity to insulin was studied in rat experiments. The sensitivity was judged from the duration of hypoglycemic coma development after intravenous infusion of 40 U/kg insulin. Sensitivity to insulin increased with the beta-adrenergic blocking agent obsidan and the alpha-adrenomimetic mesaton (phenylephrine hydrochloride) but diminished after infusion of the beta-adrenomimetic partusisten and the alpha-adrenergic blocking agent butyroxane. The obtained data are discussed from the standpoint of insulin-resistance control.

[The correlation of endogenous and exogenous factors in the occurrence and course of mental disorders in cerebral atherosclerosis]. / Sootnoshenie éndogennykh i ékzogennykh faktorov v vozniknovenii i techenii psikhicheskikh rasstroistv pri tserebral'nom ateroskleroze.

The influences of endogenous factors (sex, age, premorbid personality traits, heredity) and exogenous factors (somatogenias, cranial injuries and neuroinfections, intoxications, psychogenias) on the origin and course of psychotic syndromes and dementia were regarded on the basis of clinical and epidemiological studies carried out in 523 patients with cerebral atherosclerosis. The leading risk factors were established for each form of mental disorders due to cerebral atherosclerosis.