Abnormal sebaceous gland differentiation in 10 kittens ('sebaceous gland dysplasia') associated with generalized hypotrichosis and scaling.

A rare congenital dermatosis, characterized by progressive hypotrichosis with variable scaling and crusting, occurred in 10 short-haired kittens in North America and Europe. Lesions appeared at between 4 and 12 weeks of age, commencing on the head and becoming generalized. The tail was spared in two kittens. Generalized scaling was mild to moderate, often with prominent follicular casts. Periocular, perioral, pinnal and ear canal crusting was occasionally severe. The skin was thick and wrinkled in two kittens. Histologically, the main lesion was abnormal sebaceous gland morphology. Instead of regular differentiation from basal cells to mature sebocytes, the glands were composed of a haphazard collection of undifferentiated basaloid cells, some partly vacuolated and a few containing eosinophilic globules. Mitotic figures and apoptotic cells were present in an irregularly thickened follicular isthmus. Lymphocytic mural folliculitis and mild sebaceous adenitis were rare. Orthokeratotic hyperkeratosis and follicular casts were present. Hair follicles were of normal density and were mostly in anagen, but some contained malacic hair shafts. Perforating folliculitis, leading to dermal trichogranuloma formation, occurred occasionally. Further biopsy samples taken at 2 years and at 3 and 4 years, respectively, from two kittens revealed similar but often more severe sebaceous gland lesions. Hair follicles were smaller, with many in telogen. The young age of onset suggests a genetic defect interfering with sebaceous and, possibly, follicular development. These lesions are discussed with reference to studies of mouse mutants in which genetic defects in sebaceous differentiation cause a similar phenotype of hyperkeratosis and progressive alopecia.

Indolent cutaneous T-cell lymphoma presenting as cutaneous lymphocytosis in dogs.

Cutaneous lymphoproliferative diseases encompass a spectrum of lesions, ranging from self-limiting, reactive infiltrates to high-grade lymphomas. In humans, cutaneous lymphocytosis (CL) refers to self-limiting or slowly progressive monomorphic lymphocytic infiltrates of mostly unknown cause. It morphologically mimics cutaneous lymphoma. CL in cats also is a slowly progressive disease. Immunophenotyping and clonality testing of feline CL support an indolent lymphoma for the majority of cases studied. This study reports CL in dogs. Erythematous, scaly and alopecic macules, patches or plaques were present in eight dogs. Breed predilection was not observed; six of eight dogs were females; and ages ranged from 5 to 14 years. Diffuse monomorphic non-epitheliotropic infiltrates of CD3(+) (eight of eight), CD45(-) (four of eight) or CD45(+/-) (four of eight) and CD45RA(-) (seven of eight) T lymphocytes were present in the superficial and mid-dermis. Further immunophenotyping of five cases revealed TCR-gammadelta(+) T cells (one of five) or TCR-alphabeta(+) (four of five) T cells. TCR-alphabeta(+) populations were either CD8(+) (two of four) or CD4(-)CD8(-) (2/4). Clonality testing found clonal (seven of eight) or pseudoclonal (one of eight) rearrangement of the TCR-gamma locus of the lesional T cells. Prednisone, prednisolone and methylprednisolone acetate were the most commonly administered drugs. The lesions remained stable for long periods up to 6 years. Five dogs were euthanized due to progression of the skin lesions (three of five), peripheral lymphadenopathy of unknown origin (one of five) or high-grade lymphoma (one of five). One dog was lost for follow-up and two dogs are still alive (17 and 9 months after diagnosis). Canine CL is best considered an initially indolent lymphoma, with slow progression and a potential for progression to high-grade lymphoma.

Morphologic and immunologic characterization of a canine isthmus mural folliculitis resembling pseudopelade of humans.

The clinical, histopathologic and immunopathologic features of a novel form of isthmus mural folliculitis in dogs, which resembles pseudopelade in humans, were characterized. Clinically, dogs exhibited variably distributed foci of alopecia that persisted without treatment or did not respond to immunosuppressive therapy. Histopathologically, mixed mononuclear cell infiltrates, largely lymphocytes, infiltrated the follicular isthmus. Occasionally, inflammation extended above and below the follicular isthmus but did not involve the hair bulb or the epidermis. Severe follicular atrophy and variable atrophy of sebaceous glands occurred in all dogs. Folliculotropic lymphocytes exhibited most commonly CD3 and CD8 (cytotoxic T cells). Autoantibodies specific for the lower hair follicle were detected in the serum of affected patients. Western immunoblotting demonstrated binding of these antibodies to multiple follicular keratinocyte proteins, including hair keratins and trichohyalin. Lack of hair regrowth (in contrast to canine alopecia areata), as well as location of inflammation and extreme atrophy of adnexal units are similar to findings seen in human pseudopelade.

Paraneoplastic alopecia associated with internal malignancies in the cat.

Abstract A paraneoplastic alopecia associated with internal malignancy is reported in four cats. Acute, bilaterally symmetrical, ventral glistening alopecia, weight loss and lethargy were present in all cats. Skin biopsy specimens exhibited severe follicular and adnexal atrophy with follicular miniaturization, minimal inflammation and, in many cases, absence of stratum corneum. At the time of díagnosis, three cats had a metastatic pancreatic adenocarcinoma and one had a bile duct carcinoma. This report confirms, and expands upon the previous report of a syndrome associating ventral alopecia and metastatic visceral carcinomas in cats. Résumé- Une alopécie paranéoplasique associée à une tumeur interne maligne est observée sur 4 chats. Les symptômes sont caractérisés par une alopécie symétrique et bilatérale sur le ventre avec un aspect brillant et lisse, un amaigrissement, une lethargic Les lésions histopathologiques sont caractérisées par une atrophie folliculaire et annexielle avec des petits follicules pileux, une inflammation dermique discréte et dans beaucoup de cas, une absence du stratum corneum. Trois chats présentent un adénocarcinome pancréatique métastasé et un chat un cholangiocarcinome. Ces cas confirment l'existence d'un syndrome associant une alopécie ventrale et des carcinomes viscéraux métastatiques chez le chat. [Pascal-Tenorio, A., Olivry, T., Gross, T. L., Atlee, B. A., Ihrke, P. J. Paraneoplastic alopecia associated with internal malignancies in the cat. (Alopécie paranéoplasique associée à des tumeurs malignes internes chez le chat.) Veterinary Dermatology 1997; 8: 47-52.] Resumen Se describe en cuatro gatos una alopecia paraneoplasica asociada a procesos malignos internos. Todos los gatos presentaban una alopecia bilateral, simétrica, ventral, de aspecto brillante, pérdida de peso y letargia. Las biopsias cutáneas mostraron atrofia folicular y adnexal marcada, miniaturización de foliculos, inflamación minima y, en muchos casos, ausencia del estrato córneo. En el momento del díagnóstico, tres de los gatos tenian un adenocarcinoma metastático y uno tenia un carcinoma de conducto biliar. Este articulo confirma y amplia un informe previo sobre el sindrome de alopecia ventral y carcinomas viscerales metastáticos en gatos. [Pascal-Tenorio, A., Olivry, T., Gross, T. L., Atlee, B. A., Ihrke, P. J. Paraneoplastic alopecia associated with internal malignancies in the cat. (Alopecia paraneoplasica asociada a procesos malignos internos en el gato.) Veterinary Dermatology 1997; 8: 47-52.] Zusammenfassung- Es wird über eine paraneoplastische Alopezie in Verbindung mit inneren malignen Prozessen bei vier Katzen berichtet. Bei alien Katzen traten eine akute bilateral symmetrische ventrale Alopezie, Gewichtsverlust und Lethargie auf. Die Hautbiopsien zeigten eine schwere follikuläre und adnexale Atrophie mit follikulärer Miniaturisation, geringer Entzündung und in vielen Fallen ein Fehlen des Stratum corneum. Zum Zeitpunkt der Diagnose litten drei Katzen an einem metastasierenden Adenokarzinom des Pankreas und eine Katze an einem Gallengangskarzinom. Dieser Bericht erhärtet und erweitert den früheren Bericht über ein Syndrom, das ventrale Alopezie in Verbindung mit metastasierenden Eingeweidekarzinomen bei der Katze beschreibt. (Paraneoplastische Alopezie in Verbindung mit inneren malignen Prozessen bei der Katze.) Veterinary Dermatology 1997; 8: 47-52.].

Follicular lipidosis in three Rottweilers.

Abstract Follicular lipidosis is reported in three young Rottweilers that developed hypotrichosis of the mahogany-coloured points of the face and feet. One dog had concurrent lightening and dulling of the remaining hair. Hair matrix cells were swollen with intracellular lipid, identified by electron microscopy and oil-red-O staining. Concurrent abnormalities in one dog included poor somatic growth and elevation in serum concentration of blood urea nitrogen and creatinine. Necropsy of this dog revealed small thyroid glands with no visible colloid production, and chronic renal disease. The two remaining dogs were otherwise healthy. One of these two dogs had partial resolution of the hair loss with persistence of mild histological changes of the hair follicles 7 months after first presentation. The second was lost to follow-up but written records had no mention of skin lésions at presentation for cruciate repair 3 years after initial recognition of the haircoat changes. To the authors' knowledge, this is the first report of follicular lipidosis in any species. Résumé- Une lipidose folliculaire est observée sur trois jeunes Rottweilers qui développent une hypotrichose des zones acajou de la face et des pieds. Un chien présente également un éclaircissement et un aspect terne des poils restant. Les cellules matricielles des poils sont gonflées par des lipides en position intracellulaire identifies par la microscopie électronique et une coloration au Rouge Congo. D'autres symptômes sont observes chez un chien: retard de croissance et des elevations de l'urémie et de la créatininémie. L'autopsie de ce chien a montré des glandes thyroidiennes petites et une insuffisance rénale chronique. Les deux autres chiens sont en bonnes santé. Un des deux chiens a présente une resolution partielle de l'hypotrichose avec une persistance modérée des modifications histopathologiques des follicules, sept mois après lä premiere visite. Le second a été perdu de vue mais des contacts par écrit ont permis de savoir que le chien ne présentait plus de lésions, trois ans après la premiere visite. A la connaissance de l'auteur, il s'agit de la premiere description de lipidose folliculaire. [Gross, T. L., Pascal-Tenorio, A., Munn, R. J., Hargis, A. M., Kline, A. Follicular lipidosis in three Rottweilers. (Lipidose folliculaire chez trois Rottweilers.) Veterinary Dermatology 1997; 8: 33-40.] Zusammenfassung- Bei drei jungen Rottweilern, die Hypotrichie an den mahagonifarbenen Stellen im Gesicht und an den Pfoten entwickelten, wird von follikulärer Lipidose berichtet. Einer der Hunde hatte gleichzeitig eine Aufhellung und Abstumpfung des übrigen Haarkleides. Haarmatrixzellen waren mit intrazellulärem Lipid angeschwollen, das mittels Elektronenmikroskopie und 'oil-Red-O' Färbung identifiziert wurde. Bei einem Hund waren gleichzeitig schlechtes somatisches Wachstum und erhoehte Harnstoff-und Kreatininspiegel im Serum feststellbar. Nekropsie dieses Hundes ergab kleine Schilddrüsen ohne wahrnehmbare Kolloidproduktion und chronische Nierenerkrankung. Die zwei anderen Hunde wareii ansonsten gesund. Das Haarkleid einer der beiden Hunde wuchs teilweise wieder, leichte histologische Veränderungen waren 7 Monate nach der ersten Unetersuchung immer noch vorhanden. Der zweite Fall wurde nicht weiterverfolgt, jedoch erwähnten die Krankenberichte 3 Jahre nach dem Beginn der Haarkleidveränderungen keine diesbezüglichen Anomalien. Soviel die Autoren wissen, ist dieses der erste Bericht über follikuläre Lipidose bei Tieren. [Gross, T. L., Pascal-Tenorio, A., Munn, R. J., Hargis, A. M., Kline, A. Follicular lipidosis in three Rottweilers. (Folliculäre Lipidose bei 3 Rottweilern.) Veterinary Dermatology 1997; 8: 33-40.] Resumen Se describió una lipidosis folicular en tres Rottweilers jóvenes que desarrollaron hipotricosis en los puntos color caoba de la cara y patas. Uno de los perros tenia a su vez el resto del pelo más claro y mate. Les células de la matriz del pelo se encontraban tumefactas, con lipido intracelular identificado medíante microscopia electrónica y tinción roja-O. Un perro presentaba concomitantement crecimiento somático deficiente y elevaciones séricas de BUN y creatinina. El estudio de necropsia en este perro revaló glándulae tiroides de pequeño tamaño, sin producción de coloide visible, asi como enfermedad renal crónica. Los otros dos animales se encontraban en buen estado de salud. Uno de ellos experimentó una resolución parcial de la pérdida de pelo con persistencia de alteraciones histológicas leves de los foliculos 7 meses después de la primera presentación. No fue posible el seguimiento del segundo perro, pero no se mencionaban lesiones cutáneas en el informe escrito del animal al presentarse 3 años después para una intervención de ligamentos cruzados, después de la alteraciones iniciales. Según nuestros datos, esta es la primera descripción de lipidosis folicular en cualquier especie. Gross, T. L., Pascal-Tenorio, A., Munn, R. J., Hargis, A. M., Kline, A. Follicular lipidosis in three Rottweilers. (Lipidosis folicular en tres Rottweilers.) Veterinary Dermatology 1997; 8: 33-0.].

Calcinosis circumscripta and renal dysplasia in a dog.

Abstract A young Lhasa Apso was presented with lameness, resulting from calcinosis circumscripta of the metatarsal and metacarpal pads. Renal failure was detected by analysis of serum chemistry; concurrent hypercalcaemia and hyperphosphataemia were present. Renal dysplasia was evident upon post-mortem examination. Calcinosis circumscripta was a likely manifestation of metastatic calcification. Because soft tissue calcification in renal failure may be partly dystrophic in nature, pawpad involvement in this dog may have resulted from conformational stresses that allowed damage to these tissues. This is the first report of calcinosis circumscripta associated with canine renal dysplasia. Résumé- Un jeune Lhassa Apso est présenté en consultation pour une bolterie due à une calcinose circonscrite des coussinets métatarsiens et métacarpiens. Une insuffisance rénale a été retrouvée sur le bilan biochimique, qui démontrait à la fois une hypercalcémie et une hyperphosphatémie. L'autopsie a révélé une dysplasie rénale. La calcinose circonscrite était vraisemblablement une manifestation de calcification métastatique. Comme la calcification des tissus mous de l'insuffisance rénale est partiellement de nature dystrophique, il est possible que l'atteinte des coussinets chez ce chien ait été le résultat de stress qui ont entrainé une alteration de ces tissus. C'est le premier cas décrit de calcinose circonscrite associéà une dysplasie rénale chez le chien. [Gross, L.T. Calcinosis circumscripta and renal dysplasia in a dog. (Calcinose circonscrite et dysplasie rénale chez un chien.) Veterinary Dermatology 1997; 8: 27-32.] Resumen Se presentó un Lasha Apso joven con una cojera debida a calcinosis circumscripta de los cojinetes metatarsianos y metacarpianos. Se detectó fallo renal medíante el análisis de bioquimica sérica; existia hipercalcemia e hiperfosfatemia concurrentes. El examen post mortem hizo evidente una displasia renal. La calcinosis circumscripta era una manifestación probable de calcificación metastática. Puesto que la calcification de tejidos blandos en el fallo renal puede ser parcialmente de naturaleza distrófica, la afectación de los cojinetes palmares y plantares en este perro pudo haber resultado del estres en la conformation de los tejidos, permitiendo el daño de los mismos. Este es el primer caso descrito de calcinosis circumscripta asociada a la displasia renal en el perro. [Gross, L.T. Calcinosis circumscripta and renal dysplasia in a dog. (Calcinosis circumscripta y displasia renal en un perro.) Veterinary Dermatology 1997; 8: 27-32.] Zusammenfassung- Ein junger Lhasa Apso wurde wegen Lahmheit vorgestellt, die durch eine Calcinosis circumscripta der Metatarsal-und Metakarpalballen verursacht wurde. Das Nierenversagen wurde bei der Analyse des Blutsérums entdeckt; eine gleichzeitige Hyperkalzämie und Hyperphosphatämie waren vorhanden. Die Nierendysplasie wurde bei der Sektion offensichtlich. Die Calcinosis circumscripta war wahrscheinlich eine Manifestation einer metastaslerenden Kalzifizierung. Da Weichtellkalzlfizierung bei Nierenversagen teilweise dystropher Natur sein kann, kann die Beteiligung der Pfotenballen bei diesem Hund durch Anpassungsstreß verursacht sein, weicher Schaden dieser Gewebe ermöglichte. Dies ist der erste Bericht über eine Calcinosis circumscripta in Verbindung mit Nierendysplasie beim Hund. [Gross, L.T. Calcinosis circumscripta and renal dysplasia in a dog. (Calcinosis circumscripta und Nierendysplasie bei einem Hund.) Veterinary Dermatology 1997; 8: 27-32.].

Subepidermal bullous dermatosis due to topical corticosteroid therapy in dogs.

Six adult dogs were presented with an unusual bullous dermatosis affecting the glabrous skin of the ventral abdomen and medial thighs. Clinically, flaccid bullae were accompanied by erythema, ulceration, haemorrhage and hyperpigmentation in four of six dogs; the remaining two dogs had thin skin without grossly apparent bullae. Histologically, subepidermal bullae and clefting, vascular proliferation and dilatation (phlebectasia), and alteration in the density and staining of superficial dermal collagen were seen in all dogs. In all cases, corticosteroid-containing topical products had been applied to the affected areas prior to the development of the dermatosis; skin lesions resolved when topical corticosteroids were withdrawn. Follow-up biopsy of three dogs showed resolution of the previously abnormal collagen and subepidermal clefting. Residual lesions included phlebectasia, comedones and hyperpigmentation. The authors postulate that subepidermal clefting was due to local, corticosteroid-induced skin fragility. This is the first report, to our knowledge, of bullous skin disease in dogs resulting from topical corticosteroid therapy.

Systemic lupus erythematosus in a cat: fulfillment of the American Rheumatism Association criteria with supportive skin histopathology.

Systemic lupus erythematosus (SLE) was diagnosed in a 9-year-old castrated male Persian cat. The cat described is the first to fulfil four of 11 American Rheumatism Association criteria for the diagnosis of SLE in humans (symmetrical facial dermatitis, thrombocytopenia, positive antinuclear antibodies, oral ulceration) with supportive skin histopathology. Haematological abnormalities included a mild anaemia and severe thrombocytopenia. Skin disease consisted of symmetrical multifocal alopecia with crusting, predominantly on the face. Histopathology of the skin revealed interface dermatitis and interface folliculitis with follicular atrophy. Complete remission was obtained with corticosteroid therapy.

Colour dilution alopecia in seven Dachshunds. A clinical study and the hereditary, microscopical and ultrastructural aspect of the disease.

Abstract Seven Dachshunds from five different families were studied for late-onset alopecia. All were born blue and tan in litters containing unaffected wild boar coated animals. Six of the seven dogs changed their colour during the first months of their life from blue and tan to 'deadleaf' or grey and tan. Histopathology, light microscopy of hairs and scanning electron microscopy of the hairs showed similarities with those previously described in blue Doberman Pinschers and confirmed the diagnosis of colour dilution alopecia (CDA). Transmission electron microscopy of cross-sectioned hairs showed vacuoles containing melanin granules of different size in medullary, subcortical and intracortical areas. Some opened at the hair surface and released melanin granules. Study of the pedigree proved autosomal recessive inheritance. Résumé- 7 teckels de 5 families ont fait l'objet de cette étude. Tous sont nés bleu et feu et proviennent de portées comprenant des chiots sains couleur sanglier. Six de ces chiens ont changé leur couleur durant les premiers mois de leur vie, passant ainsi du bleu et feu à'feuilles mortes' ou gris et feu. Histologiquement, l'examen microscopique des poils et l'examen ultrastructural à balayage montrent des lésions similaires à celles décrites chez les Dobermanns Pinschers bleus, et confirment le diagnostic d'Alopécie des Robes Diluées (ARD). La microscopie électronique à transmission des poils sectionnés montre des vacuoles contenant des grains de mélanine dans les régions médullaires, subcorticales, et intracorticales des poils. Quelques poils montrent la sortie des granules de mélanine à la surface du poil. L'étude des pédigrés prouve un mode de transmission autosomal récessif de cette maladie. [Beco, L., Fontaine, J., Gross, T.L., Charlier, G. Colour dilution alopecia in seven Dachshunds. A clinical study and the hereditary, microscopical and ultrastructural aspects of the disease (Alopécie des Robes Diluées chez 7 teckels: étude clinique et aspects héréditaires, microscopiques et ultrastructuraux). Veterinary Dermatology 1996; 7: 91-97.] Resumen Se estudió la alopecia de aparición tardía en siete perros Dashshund de cinco familias diferentes. Todos los cachorros nacieron de color azul y canela en camadas que contenían animates con pelaje jabalí, sin afectación. Seis de los siete perros cambiaron su color durante los primeros meses de vida de azul y canela a 'hoja seca' o gris y canela. La histopatologia, la microscopía óptica de los pelos y la microscopía electrónica de barrido de los pelos mostraron similitudes con los previamente descritos en los Doberman Pinscher azules y confirmaron el diagnóstico de alopecia de color diluido (ACD). La microscopia electrónica de transmisión de cortes transversales del pelo mostraron vacuolas que contenían gránulos de melanina de tamaño variable en las zonas medular, subcortical e intracortical. Algunos se abrían a la superficie del pelo y liberaban gránulos de melanina. El estudio del pedigree reveló una forma de herenicia autosómica recesiva. [Beco, L., Fontaine, J., Gross, T.L., Charlier, G. Colour dilution alopecia in seven Dachshunds. A clinical study and the hereditary, microscopical and ultrastructural aspects of the disease (Alopecia de color diluido en siete Dachshunds. Estudio clinico y aspectos hereditarios, microscopicos y ultraestructurales de la enfermedad). Veterinary Dermatology 1996; 7: 91-97.] Zusammenfassung- Sieben Dackel aus fünf verschiedenen Familien wurden wegen Alopezie mit spätem Beginn untersucht. Alle wurden als 'blau und tan' in Würfen geboren, die gesunde saufarbene aufwiesen. Sechs der sieben Hunde änderten ihre Farbe während der ersten Lebensmonate von 'blau und tan' nach 'dürrlaub' oder 'grau und tan'. Histopathologisch zeigten Lichtmikroskopie der Haare und Elektronen-mikroskopabtastung der Haare Ähnlichkeiten mit denen früher beschriebener Veränderungen beim blauen Dobermann, und bestätigten die Diagnose Farbverdünnungsalopezie (CDA). Die Transmissionselek-tronenmikroscopie von quergeschnittenen Haaren zeigte Vakuolen, die Melaningranula verschiedener Größe in medullären, subkortikalen und intrakortikalen Zonen enthielten. Einige öffneten sich hin zur Haarober fläche und entließen die Melaningranula. Die Untersuchung der Abstammung zeigte eine autosomal rezessive Erblichkeit. [Beco, L., Fontaine, J., Gross, T. L., Charlier, G. Colour dilution alopecia in seven dachschunds. A clinical study and the hereditary microscopical and ultrastructural aspects of the disease (Farbverdünnungsalopezie bei sieben Dackeln. Eine klinische Studie über erbliche, mikroskopische und ultrastrukturelle Aspekte dieser Erkrankung). Veterinary Dermatology 1996; 7: 91-97.].

Putative Diethylcarbamazine-induced Urticaria with Eosinophilic Dermatitis in a Dog.

Résumé- Une urtricaire due à la diethylcarbamazine associée à une dermite prurigineuse a été suspectée chez un chien mâle castré croisé Retriever. L'animal présentait des lésions d'urticaire multiples qui avaient tendance à fusionner au niveau des paupières, des lèvres, les conques auriculaires et du prépuce. Les biopsies cutanées ont révélé un infiltrat périvasculaire et périannexiel intense riche en polynucléaires éosinophiles. Parfois les polynuclaires éosinophiles étaient "dégranulés" ou présentaient des formes "en flamme". La suppression de l'administration de diethylcarbamazine a été suivie d'une disparission rapide de toutes les lésions cutanées. L'hypothèse d'une réaction immune à la diethylcarbamazine est proposée. [Vitale, C. B., Ihrke, P. J., Gross, T. L. Putative diethylcarbamazine-induced uticaria with eosinophilic dermatitis in a dog. (Probable urticaire et dermite éosinophilique induites par la diethylcarbamazine chez un chien). Resumen- Se describe el caso de un perro macho castrado, cruzado de retriever que presentaba una dermatitis pruritica con urticaria supuestamente inducida por dietilcarbamacina. El perro mostraba multiples habones, principalmente alrededor de los ojos, la boca, los pabellones auriculares y el prepucio. El estudio histológico mostró un infiltrado perivascular y perianexal, con predominancia de eosinófilos. Ocasionalmente los eosinófilos degranulaban formando "figuras en llama". La retirada de la terapia con dietilcarbamacina fue seguida por una mejoria rápida y espectacular de todas las lesiones cutáneas. Se postula una reacción adversa a la dietilcarbamacina mediada por factores inmunológicos. [Vitale, C. B., Ihrke, P. J. and Gross, T. L. Putative diethylcarbamazine-induced urticaria with eosinophilic dermatitis in a dog (Urticaria con dermatitis eosinofilica supuestamente inducida por dietilcarbamacina en un perro). Zusammenfassung- Es wird über eine vermutlich Diethylcarbamazin-verursachte Urtikaria mit Juckreiz bei einem männlich-kastrierten Retrievermischling berichtet. Der Hund wies generalisiert multifokale Striemen auf, die dazu tendierten um Augen, Mund, Ohrmuscheln und Präputium zusammenzulaufen. Die Hautbiopsie zeigte ein starkes perivaskuläres und periadenxales Infiltrat mit vorwiegend eosinophilen Granulozyten. Gelegentlich degranulierten die Eosinophilen zu "Flammenform". Das Absetzen von Diethylcarbamazin führte zu einer dramatischen und raschen Abheilung aller Hautveranderungen. Es wird eine immunologischvermittelte Arzneimittelreaktion auf Diethylcarbamazin vermutet. [Putative diethylcarbamazine-induced utricaria with eosinophilic dermatitis in dogs (Vermutlich Diethylcarbamazin-verursachte Urtikaria mit eosinophiler Dermatitis beim Hund). Abstract- A suspected diethylcarbamazine-induced urticarial dermatitis with associated pruritus is reported in a castrated male mixed breed retriever. The dog had generalized multifocal wheals that tended to cluster around the eyes, mouth, pinnae, and prepuce. Skin biopsy revealed an intense perivascular and periadnexal infiltrate with eosinophils predominating. On occasion, eosinophils degranulated to form "flame figures". Withdrawal of diethylcarbamazine resulted in dramatic and rapid resolution of all skin lesions. An immunologically mediated adverse drug reaction to diethylcarbamazine is proposed.