[The irradiation sequelae in children with lymphogranulomatosis]. / Bestrahlungsfolgen bei Kindern mit Lymphogranulomatose.

1. 37 children with M. Hodgkin received radiotherapy to the involved cervical lymph nodes at the II. Children's Hospital in Berlin-Buch during 1971-1986. 2. Localised growth disturbances and muscle atrophies were observed as late effects. 12 children had severe sequelae and 19 patients moderate late effects. 3. The effects were stronger the younger the children were at the time of irradiation.

[The endocrinological aspects of the therapy of testicular involvement in children with acute leukemias]. / Endokrinologische Aspekte zur Therapie des Hodenbefalls bei Kindern mit akuten Leukämien.

Orchidectomy or testicular irradiation with 24 to 30 Gy are recommended for testicular involvement in boys with acute lymphoblastic leukemia. But, recommended radiation doses for the only occultly involved other testis differ, i.e. they range from 12 to 24 Gy. Low dose (12 or 15 Gy) "preventive" testicular irradiation was delivered to 5 of 14 patients; only one of these 5 experienced a further testicular relapse. According to our observation, in contrast to higher doses, the dose limitation allows spontaneous pubertal development including normal testosterone production and normal development of the masculine stature.

Immunologic parameters of children with acute leucosis after cessation of polychemotherapy under repeated immunostimulation with intradermal B.C.G.

11 children with acute leucosis (10 with ALL, 1 with AML) showed a significant increase of the absolute number of lymphocytes and E-rosette forming cells in the peripheral blood after 3-years-polychemotherapy under repeated intradermal B.C.G. vaccination. Such an increase of the absolute number of lymphocytes could not be found in an analogous control group without immunostimulation. At present 14 children with acute leucosis (11 with ALL, 3 with AML) in our hematologic-oncologic primary center of Rostock are still living in a first stable remission from the first up to the third year under regular immunostimulation with intradermal B.C.G. when polychemotherapy off.

[Experiences with miconazole in the prevention and therapy of candidiasis]. / Erfahrungen mit Miconazol. in der Prophylaxe und Therapie von Sprosspilzinfektionen.

1. The treatment of 26 children suffering from haemoblastoses and tumors by the antimycotic Miconazol is reported on. 2. The application took place prophylactically as well as therapeutically by an oral or intravenous administration. Mycological examinations (stools, urine, throat swab, blood) have been carried through before, during and after the treatment in weekly intervals. 3. The result of treatment is altogether to be called good, invasive mycoses have been prevented and proved Blastomyces infections successfully treated. 4. Side effects like nausea and vomiting were observed only in one case, damages of the haematopoietic system, the liver and kidneys could not have been demonstrated.