RESUMEN
Commercial inactivated culture polyvaccine against herpes simplex viruses (types 1 and 2) developed at D. I. Ivanovsky Institute of Virology promoted cessation of viremia. During the first vaccination viremia coincided with appearance of a focal allergic test on the retina, which is proposed for the diagnosis of herpetic involvement of the posterior compartment of the eye. T-cellular immunity normalized after a course of vaccination. Experimental immunization of rats and vaccination of patients with chronic ophthalmic and genital herpes demonstrated the therapeutic activity of inactivated herpetic polyvaccine in suppositoria.
Asunto(s)
Herpes Genital/terapia , Queratitis Herpética/terapia , Vacunas Virales/uso terapéutico , Animales , Herpes Genital/sangre , Herpes Genital/inmunología , Humanos , Queratitis Herpética/sangre , Queratitis Herpética/inmunología , Ratas , Linfocitos T/inmunología , ViremiaRESUMEN
A promising dosage form of interferon inductor poludan has been developed for the treatment of patients with genital herpes and ophthalmic herpes: suppositoria. High interferon-producing and antiviral activity of poludan in suppositoria is potentiated by hyaluronic acid and antioxidants.