Principales aspectos de la producción científica y editorial de MEDISAN en el quinquenio 2017-2021 / Main aspects of MEDISAN's scientific and editorial production in the five- year period 2017-2021 i:en

Introducción: En el mundo académico, la publicación científica se ha convertido en un problema constante, tanto en sus elementos cuantitativos como en los cualitativos. Objetivo: Caracterizar el nivel de publicación de MEDISAN según algunos aspectos de su producción científica y editorial. Métodos: Se realizó una investigación observacional, descriptiva y transversal, del tipo bibliométrico, de la producción científica en la revista MEDISAN de Santiago de Cuba durante el quinquenio 2017-2021. La población de estudio quedó conformada por todos los artículos científicos publicados en ese periodo según los registros de las bases de datos SciELO Citation Index y Google Académico, así como los de la propia revista en la plataforma Open Journal Systems. Resultados: Durante el periodo analizado se publicaron 38 números, que incluyeron 679 artículos y 2367 autores. Se destacaron el año 2017 con mayor cantidad de publicaciones (31,8 %) y el año 2019 con una menor cifra (14,3 %). Los autores cubanos presentaron una contribución superior (629 artículos), sobre todo los de la provincia de Santiago de Cuba, donde sobresalieron los profesionales de la Universidad de Ciencias Médicas, con 50,1 % de toda la producción. El índice h5 reveló una tendencia al aumento de las citas que recibió la revista, dado que en el año 2021 su resultado fue 23 y en el 2022 se incrementó a 27. Conclusiones: El análisis de la producción científica y editorial reveló las fortalezas y debilidades de la revista, lo que permite trazar políticas para aumentar su calidad y, con ello, su visibilidad en bases de datos.

Introduction: In the academic world, scientific publication has become a constant problem, both in its quantitative and qualitative elements. Objective: To characterize MEDISAN's publication rate according to some aspects of its scientific and editorial production. Methods: An observational, descriptive and transversal research, of bibliometric type, was carried out on the scientific production of MEDISAN journal from Santiago de Cuba during the five-year period 2017-2021. The study population was made up of all scientific articles published in that period according to the records of SciELO Citation Index and Google Scholar databases, as well as those of the journal itself on the Open Journal Systems. Results: During the analyzed period, 38 issues were published, which included 679 articles and 2,367 authors. The year 2017 stood out with the highest number of publications (31.8%) and the year 2019 with a lower number (14.3%). Cuban authors had the greatest contribution (629 articles), especially those from Santiago de Cuba province, where professionals from University of Medical Sciences stood out, with 50.1% of all production. The h5 index revealed a trend of increasing citations received by the journal, since in 2021 it was 23 and in 2022 it increased to 27. Conclusions: The analysis of scientific and editorial production revealed the strengths and weaknesses of the journal, which makes it possible to draw up policies to increase its quality and, with it, its visibility in databases.

Vulvar High-Grade Squamous Intraepithelial Lesions Treated with Imiquimod: Can Persistence of Human Papillomavirus Predict Recurrence?

Objectives: Vulvar high-grade squamous intraepithelial lesion (vulvar HSIL) or vulvar intraepithelial neoplasia (VIN) is a premalignant condition that can progress to carcinoma. Imiquimod is a topical drug with high effectiveness and low morbidity. We aimed (1) to assess the long-term response to imiquimod in a cohort of patients with vulvar HSIL and (2) and to analyze the role of HPV determined in pre- and post-imiquimod treatment biopsies in the persistence or recurrence of vulvar HSIL. Design: Retrospective study between 2011 and 2022. Setting: Referrals from the primary care area of Baix Llobregat treated in the gynecology department of a university hospital in Barcelona, Spain. Population: 20 women with vulvar HSIL treated with imiquimod. Methods: The inclusion criteria were vulvar HSIL, vulvar HPV determination by pre- and post-treatment biopsy, acceptance of medical treatment, at least one follow-up and 4 weeks of treatment. Main outcome measures: Histological diagnosis of vulvar HSIL with pre- and post-imiquimod HPV determination. Response to treatment (complete, partial, no response, recurrence). Results: After imiquimod, 10 (50%) and 6 (30%) cases had complete and partial responses, respectively. Another 4 cases (20%) did not respond. Before treatment, 19 (95%) cases were positive for vulvar HPV (16 cases had HPV type 16). After treatment, 10 cases (50%) were positive for HPV (8 cases with HPV type 16): 2 cases (20%) with a complete response, 5 cases (83.3%) with a partial response and 3 cases (75%) with no response. Eight of the 10 HPV-negative cases (80%) post-treatment showed a complete response. HPV type 16 was present in 16 cases (84.2%) pre-treatment and in 8 cases (80%) post-treatment. Ten patients underwent additional treatments following a partial response, no response or recurrence. The 2 HIV and 3 immunosuppressed patients treated with imiquimod showed a partial response and required additional treatment. All these patients were HPV-positive pre- and post-treatment (100%). Response to imiquimod was associated with post-treatment vulvar HPV positivity (p = 0.03). The median time to a complete response in HPV-negative cases was 4.7 months versus 11.5 months in HPV-positive cases post-imiquimod treatment. Recurrence of vulvar HSIL was observed in 7 patients (35%), with a median time to recurrence of 19.7 months (range 3.2-32.7). Recurrence was experienced in 10% of cases with a complete response, in 4/6 (66.6%) cases with a partial response, and in 2/4 (50%) women with no response. Four of the 7 recurrent cases (57%) were infected with HIV or immunosuppressed. Six (85%) of the recurrent cases were HPV-positive post-treatment (all were HPV type 16). Four (30.7%) of the non-recurrent cases were HPV-positive post-treatment with imiquimod (p = 0.05), two of which were HPV type 16 (50%). Conclusions: Imiquimod effectively treats vulvar HSIL. Cases with a complete response showed less HPV positivity post-treatment than partial or non-response cases. Recurrences were more frequent in those with a partial or no response to imiquimod, and in immunosuppressed patients. In recurrent cases, 85% were HPV-positive post-treatment, while 30.7% of non-recurrent cases were HPV-positive. HPV positivity in the post-treatment biopsy suggests the need for stricter follow-up of patients.

CRABP2 - A novel biomarker for high-risk endometrial cancer.

OBJECTIVE: Investigate the clinical and functional implications of elevated CRABP2 expression in endometrial cancer (EC) patients. METHODS: Patients were stratified into high and low CRABP2 expression groups using a decision tree classifier. Univariate and multivariate statistical analyses determined the prognostic and clinicopathological consequences of increased CRABP2 expression. A CRABP2 gene signature was generated using differential expression analysis, and analyzed using network-based approaches. The findings were validated in The Clinical Proteomic Tumor Analysis Consortium (CPTAC), a newly generated cohort of 120 endometrial tissues, and The Cancer Dependency Map (DepMap). RESULTS: 60 (11%) patients in TCGA had high CRABP2 expression, whilst 468 (89%) had low expression. High expression was associated with serous EC, reduced overall survival, advanced stage and grade. Downstream retinoic acid receptors (RARG and RARA) were correlated with CRABP2 expression and were associated with worse prognosis in serous EC. The CRABP2 gene signature was enriched for Polycomb target gene sets, and was regulated by ELP3 and BMP7. BMP7 expression was increased in the CRABP2-high group, was associated with worse prognosis, and CRISPR-Cas9 screens revealed correlations in its cell-fitness score with CRABP2 following gene knockout. The opposite was true for ELP3, suggesting opposing effects from both master regulators. CONCLUSIONS: CRABP2 expression is associated with poor prognosis and advanced EC. The expression of RARA and RARG correlates with CRABP2 and are associated with worse prognosis in advanced histological subtypes. Polycomb target gene sets and two master regulators, ELP3 and BMP7, were identified as functionally relevant mechanisms driving aberrant CRABP2 expression.

Luisa Francisca Acosta Ortega. Liderazgo con nombre de mujer / Luisa Francisca Acosta Ortega. Lidership with a woman´s name

En este artículo se resaltan las cualidades humanas y otros aspectos de la vida de quien fuera Vicedecana Académica de la Facultad de Estomatología y posteriormente Directora del Centro Provincial de Información de Ciencias Médicas de Santiago de Cuba, en el período de abril del 2014 hasta abril del 2022. Se destacan los logros alcanzados a lo largo de su quehacer, desde que inició en la Universidad Médica hasta nuestros días, así como su valioso aporte a la docencia y a la formación de diversos grupos de educandos, además, se realzan los avances alcanzados en la revista MEDISAN en su etapa de Directora del Centro de Información hasta el día de su feliz jubilación.

The human qualities and some other aspects of the life of the Academic Vice-dean of the Estomatological Faculty and then the Head of the Provincial Information Center of Medical Sciences from Santiago de Cuba are highlighted in this work, in the period from April, 2014 to the same month in 2022.The achievements reached during her working life, since she began in the Medical University up to the present, as well as her valuable dedication to the teaching and training of different groups of students are presented, besides compiling achievements in journal MEDISAN during her leadership as Director of the Provincial Information Center up to the day of her happy retirement.

Clinical correlation of lymphovascular invasion and Silva pattern of invasion in early-stage endocervical adenocarcinoma: proposed binary Silva classification system.

Silva invasion pattern can help predict lymph node metastasis risk in endocervical adenocarcinoma. We analysed Silva pattern of invasion and lymphovascular invasion to determine associations with clinical outcomes in stage IA and IB1 endocervical adenocarcinomas. International Federation of Gynecology and Obstetrics (FIGO; 2019 classification) stage IA-IB1 endocervical adenocarcinomas from 15 international institutions were examined for Silva pattern, presence of lymphovascular invasion, and other prognostic parameters. Lymph node metastasis status, local/distant recurrences, and survival data were compared using appropriate statistical tests. Of 399 tumours, 152 (38.1%) were stage IA [IA1, 77 (19.3%); IA2, 75 (18.8%)] and 247 (61.9%) were stage IB1. On multivariate analysis, lymphovascular invasion (p=0.008) and Silva pattern (p<0.001) were significant factors when comparing stage IA versus IB1 endocervical adenocarcinomas. Overall survival was significantly associated with lymph node metastasis (p=0.028); recurrence-free survival was significantly associated with lymphovascular invasion (p=0.002) and stage (1B1 versus 1A) (p=0.002). Five and 10 year overall survival and recurrence-free survival rates were similar among Silva pattern A cases and Silva pattern B cases without lymphovascular invasion (p=0.165 and p=0.171, respectively). Silva pattern and lymphovascular invasion are important prognostic factors in stage IA1-IB1 endocervical adenocarcinomas and can supplement 2019 International Federation of Gynecology and Obstetrics staging. Our binary Silva classification system groups patients into low risk (patterns A and B without lymphovascular invasion) and high risk (pattern B with lymphovascular invasion and pattern C) categories.

Clear Cell Carcinoma (CCC) of the Cervix Is a Human Papillomavirus (HPV)-independent Tumor Associated With Poor Outcome: A Comprehensive Analysis of 58 Cases.

Cervical clear cell carcinoma (CCC) is a rare human papillomavirus-independent adenocarcinoma. While recent studies have focused on gastric-type endocervical adenocarcinoma (GTA), little is known about CCC. A total of 58 (CCCs) were collected from 14 international institutions and retrospectively analyzed using univariable and multivariable methods and compared with 36 gastric-type adenocarcinomas and 173 human papillomavirus-associated (HPVA) endocervical adenocarcinoma (ECA) regarding overall survival (OS) and recurrence-free survival (RFS). Most cases were FIGO stage I (72.4%), with Silva C pattern of invasion (77.6%), and the majority were treated with radical surgery (84.5%) and adjuvant therapy (55.2%). Lymphovascular invasion was present in 31%, while lymph node metastasis was seen in 24.1%; 10.3% were associated with abdominopelvic metastases at the time of diagnosis; 32.8% had recurrences, and 19% died of disease. We did not find statistically significant differences in OS and RFS between CCC and GTA at 5 and 10 years (P=0.313 and 0.508, respectively), but there were significant differences in both OS and RFS between CCC and HPVA ECA (P=0.003 and 0.032, respectively). Also, OS and RFS in stage I clear cell and GTA were similar (P=0.632 and 0.692, respectively). Multivariate analysis showed that OS is influenced by the presence of recurrence (P=0.009), while RFS is influenced by the FIGO stage (P=0.025). Cervical CCC has poorer outcomes than HPVA ECA and similar outcomes to human papillomavirus-independent GTA. Oncologic treatment significantly influences RFS in univariate analysis but is not an independent prognostic factor in multivariate analysis suggesting that alternative therapies should be investigated.

Caracterización de las complicaciones y la mortalidad en la enfermedad cerebrovascular isquémica aguda / Complications and Mortality Characterization in Acute Ischemic Cerebrovascular Disease

RESUMEN Fundamento: las enfermedades cerebrovasculares isquémicas constituyen una emergencia neurológica. Su prevalencia aumenta progresivamente a nivel mundial, así como la morbilidad asociada, la mortalidad general y prematura. Se erige como un importante problema de salud que debe ser intervenido desde la interdisciplinariedad a todos los niveles de atención sanitaria. Objetivo: describir la incidencia de las complicaciones más frecuentes en la población de enfermos aquejados de enfermedad cerebrovascular, así como la carga de mortalidad asociada a este daño neurológico. Método: se realizó un estudio descriptivo en pacientes con enfermedad cerebrovascular isquémica que egresaron del Servicio de Neurología del Hospital Provincial Clínico Quirúrgico Docente Saturnino Lora Torres en el trienio 2017-2019. Las variables seleccionadas fueron: sexo, tipo de complicaciones, topografía de la lesión por neuroimagen, estado al egreso y causa directa de muerte. Se computaron intervalos de confianza del 95 %. Fue aplicado el test no paramétrico Chi cuadrado de independencia y se seleccionó un nivel de significación α= 0,05. Resultados: predominaron los pacientes de sexo masculino, para el 61,4 % de la muestra. El 30,7 % de los enfermos se complicaron, con predominio de la neumonía nosocomial (16,0 %) y la infección urinaria nosocomial (8,0 %). Fallecieron nueve enfermos (10,2 %), fundamentalmente, a causa de las neumopatías infecciosas (44,5 % del total de fallecidos). Conclusiones: las neumopatías infecciosas y la infección urinaria se erigen como las complicaciones a controlar en la población de enfermos afectados por enfermedad cerebrovascular isquémica, fundamentalmente, como consecuencia de lesiones cerebrovasculares hemisféricas de gran tamaño. La mortalidad por esta enfermedad se considera mínima.

ABSTRACT Background: ischemic cerebrovascular diseases constitute a neurological emergency. Its prevalence is progressively increasing worldwide, as well as associated morbidity, general and premature mortality. It stands as an important health problem that must be analyzed from an interdisciplinary approach at all levels of health care. Objective: to describe the most frequent complications incidence in the patients suffering from cerebrovascular disease population, as well as the burden of mortality associated with this neurological damage. Method: a descriptive study was carried out in patients with ischemic cerebrovascular disease who leaved from the Neurology Service of the Saturnino Lora Torres Provincial Clinical Surgical Teaching Hospital in the 2017-2019 triennium. The variables selected were: sex, type of complications, topography of the lesion by neuroimaging, state at discharge, and direct cause of death. 95 % confidence intervals were computed. The non-parametric Chi squared test of independence was applied and a significance level α = 0.05 was selected. Results: male patients predominated, for 61.4 % of the sample. 30.7 % of the patients became complicated, for the predominance of nosocomial pneumonia (16.0 %) and nosocomial urinary infection (8.0 %). Nine patients died (10.2 %), mainly due to infectious lung diseases (44.5 % of the total number of deaths). Conclusions: infectious lung diseases and urinary tract infection are the complications to be controlled in the population of patients affected by ischemic cerebrovascular disease, mainly as a consequence of large hemispheric cerebrovascular lesions. Mortality from this disease is considered minimal.

Universidad de Ciencias Médicas de Santiago de Cuba: una mirada a su producción científica / University of Medical Sciences in Santiago de Cuba: a look to its scientific production

Las universidades son uno de los ejes principales del desarrollo científico de un país y su misión ha variado a lo largo del tiempo. Estas instituciones nacieron con una primera misión que es la docencia, pero actualmente sus actividades son mucho más amplias. Al respecto, se realizó el presente estudio con el objetivo de reflexionar en torno a la producción científica en la Universidad de Ciencias Médicas en Santiago de Cuba; asimismo, se indagó acerca de la colaboración e impacto alcanzados en la última edición del Ranking Iberoamericano de Instituciones de Educación Superior, 2020. Se evidenció que el uso de indicadores bibliométricos es una alternativa para medir y evaluar la producción científica de los profesionales de la salud, así como ampliar la productividad y la visibilidad a través de estrategias y políticas trazadas, a partir de la toma de decisiones oportunas.

The universities are one of the main focal points in the scientific development of a country and its mission has varied as time goes by. These institutions were born with a first mission that is teaching, but at the moment their activities are much wider. In this respect, the present study was carried out aimed at meditating around the scientific production in the University of Medical Sciences in Santiago de Cuba; also, there was an investigation about the collaboration and impact reached in the last edition of the Ibero-American Ranking of Higher Education Institutions, 2020. It was evidenced that the use of bibliometric indicatives is an alternative to measure and evaluate the scientific production of the health professionals, as well as to enlarge the productivity and visibility through strategies and politics drawn up, taking the opportune decisions making as a starting point.

Producción científica sobre ciencias biomédicas en la provincia de Santiago de Cuba / Scientific production about biomedical sciences in the province of Santiago de Cuba

El estudio de la producción científica en salud en Cuba es un interés permanente para todos los especialistas. Con el objetivo de caracterizar la producción científica de las Ciencias Biomédicas en la provincia de Santiago de Cuba se realizó un estudio bibliométrico en la base de datos SCOPUS durante el período 1920 a 2018. Se emplearon estrategias de búsqueda y variables relacionadas con la productividad científica; se cuantificó la productividad de los autores a través del índice de Lotka; se recuperaron 919 artículos con un total de 2 484 autores y se identificó un alto porcentaje de pequeños productores. La institución con mayor aporte a la producción científica en salud fue la Universidad de Oriente. El Hospital Provincial Saturnino Lora sobresale con los mayores niveles de producción científica en el sector de la salud; el año más productivo fue el 2013 y los autores más prolíficos fueron Alicia Pons-Porrata, Zenén Fernández Rodríguez y Ricardo Hodelín Tablada. El análisis de los aspectos importantes de la producción científica permitió caracterizar la actividad investigadora y su evolución a lo largo del tiempo. Son bajos los índices de producción científica de los profesionales de la Salud en Santiago de Cuba en comparación con otras instituciones. Se advierte la necesidad de aumentar las colaboraciones con investigadores a nivel internacional y la necesidad de tomar decisiones con vistas a elevar la productividad y la visibilidad de los autores, y se sugiere que los autores e instituciones mantengan una firma única para sus publicaciones(AU)

The study of health scientific production in Cuba is a field of permanent interest for all specialists. A bibliometric study covering the period 1920-2018 was conducted in the database Scopus to characterize biomedical scientific production in the province of Santiago de Cuba. Use was made of search strategies and variables related to scientific productivity. Authors' productivity was quantified with Lotka's index. A total 919 papers were retrieved published by 2 484 authors. A high percentage of small producers was identified. The University of Oriente was the institution contributing the largest health scientific production. Saturnino Lora Provincial Hospital achieved the highest scientific production levels in the health sector. The most productive year was 2013, and the most prolific authors were Alicia Pons-Porrata, Zenén Fernández Rodríguez and Ricardo Hodelín Tablada. Analysis of important aspects of scientific production made it possible to characterize research activity and its evolution over time. Scientific production rates are low among Santiago de Cuba health professionals in comparison with other institutions. Evidence was found of the need to increase collaboration with international researchers and to take decisions aimed at enhancing the productivity and visibility of authors. It is suggested that authors and institutions maintain a single signature for their publications(AU)

Measuring the depth of invasion in vulvar squamous cell carcinoma: interobserver agreement and pitfalls.

AIMS: The depth of invasion is an important prognostic factor for patients with vulvar squamous cell carcinoma (SCC). The threshold of 1 mm distinguishes between FIGO stages IA and ≥IB disease and guides the need for groin surgery. Therefore, high interobserver agreement is crucial. The conventional and the alternative method are described to measure the depth of invasion. The aims of this study were to assess interobserver agreement for classifying the depth of invasion using both methods and to identify pitfalls. METHODS AND RESULTS: Fifty slides of vulvar SCC with a depth of invasion approximately 1 mm were selected, digitally scanned and independently assessed by 10 pathologists working in a referral or oncology centre and four pathologists in training. The depth of invasion was measured using both the conventional and alternative method in each slide and categorised into ≤1 and >1 mm. The percentage of agreement and Light's kappa for multi-rater agreement were calculated, and 95% confidence intervals were calculated by bootstrapping (1000 runs). The agreement using the conventional method was moderate (κ = 0.57, 95% confidence interval = 0.45-0.68). The percentage of agreement among the participating pathologists using the conventional method was 85.0% versus 89.4% using the alternative method. Six pitfalls were identified: disagreement concerning which invasive nest is deepest, recognition of invasive growth and where it starts, curved surface, carcinoma situated on the edge of the tissue block, ulceration and different measurement methods. CONCLUSIONS: Pathologists reached only moderate agreement in determining the depth of invasion in vulvar SCC, without a notable difference between the two measurement methods.

Molecular approaches for classifying endometrial carcinoma.

Endometrial carcinoma is the most common cancer of the female genital tract. This review article discusses the usefulness of molecular techniques to classify endometrial carcinoma. Any proposal for molecular classification of neoplasms should integrate morphological features of the tumors. For that reason, we start with the current histological classification of endometrial carcinoma, by discussing the correlation between genotype and phenotype, and the most significant recent improvements. Then, we comment on some of the possible flaws of this classification, by discussing also the value of molecular pathology in improving them, including interobserver variation in pathologic interpretation of high grade tumors. Third, we discuss the importance of applying TCGA molecular approach to clinical practice. We also comment on the impact of intratumor heterogeneity in classification, and finally, we will discuss briefly, the usefulness of TCGA classification in tailoring immunotherapy in endometrial cancer patients. We suggest combining pathologic classification and the surrogate TCGA molecular classification for high-grade endometrial carcinomas, as an option to improve assessment of prognosis.

Loss of SMARCA4 Expression Is Both Sensitive and Specific for the Diagnosis of Small Cell Carcinoma of Ovary, Hypercalcemic Type.

Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare ovarian neoplasm that occurs in young women and has a poor prognosis. The histologic diagnosis of SCCOHT can be challenging due to its rarity and relatively nonspecific histologic features, which range from the classic, first-described small cell morphology to a pattern in which there are large cells with abundant eosinophilic cytoplasm. Many entities can be in the differential diagnosis and to date, immunohistochemical stains have shown no distinctive profile and have been of limited aid. SMARCA4 (also known as BRG1) mutations have recently been reported at high frequency in these tumors. SMARCA4 is an important component of the SWI/SNF complex that regulates gene expression through alteration of nucleosome conformation. Studies to date have suggested that immunohistochemical loss of expression of SMARCA4 is associated with the presence of a SMARCA4 mutation in most cases. In this study, the sensitivity and specificity of the immunohistochemical loss of SMARCA4 expression for the diagnosis of SCCOHT is examined in the context of the differential diagnosis with other primary or metastatic ovarian tumors. All but one of the SCCOHT showed loss of SMARCA4 expression (16/17; 94%), while of 279 other tumors tested, only two tumors (one clear cell carcinoma and one ovarian melanoma) showed loss of SMARCA4 expression. We conclude that SMARCA4 immunohistochemistry is highly sensitive and specific for a diagnosis of SCCOHT and is of clinical utility in the differential diagnosis of poorly differentiated ovarian tumors.

A survey of DICER1 hotspot mutations in ovarian and testicular sex cord-stromal tumors.

Sertoli-Leydig cell tumors are characterized by the presence of somatic DICER1 hotspot mutations. In this study, we sought to define the association between DICER1 hotspot mutations and different morphologic subtypes of ovarian Sertoli-Leydig cell tumors. Furthermore, we aimed to assess whether DICER1 hotspot mutations occur in other ovarian sex cord-stromal tumors, testicular sex cord-stromal tumors, or other female genital tract tumors with rhabdomyosarcomatous differentiation. We subjected a series of ovarian Sertoli-Leydig cell tumors (n=32), Sertoli cell tumors (n=5) and gynandroblastomas (n=5), testicular sex cord-stromal tumors (n=15) and a diverse group of female genital tract tumors with rhabdomyosarcomatous morphology (n=10) to DICER1 hotspot mutation analysis using Sanger sequencing. We also tested two gynandroblastomas for the presence of FOXL2 hotspot mutations (p.C134W; c.402C>G). Twenty of 32 (63%) Sertoli-Leydig cell tumors harbored a DICER1 hotspot mutation, of which 80% had the p.E1705K mutation. No association was found between DICER1 mutation status and the presence of heterologous or retiform differentiation in Sertoli-Leydig cell tumors. DICER1 mutations were found at similar frequencies in gynandroblastoma (2/5; 40%) and ovarian Sertoli cell tumors (5/8; 63%; P>0.1), and all mutated tumors harbored a p.E1705K mutation. DICER1 hotspot mutations were also identified in a single cervical rhabdomyosarcoma and in the rhabdomyosarcomatous component of a uterine carcinosarcoma. No DICER1 mutations were detected in testicular sex cord-stromal tumors. Two DICER1 wild-type gynandroblastomas harbored a p.C134W FOXL2 hotspot mutation in both tumor components. In this study we confirmed that DICER1 hotspot mutations occur in over half of ovarian Sertoli-Leydig cell tumors, and are unrelated to tumor differentiation. We also widened the spectrum of ovarian sex cord-stromal tumors with sertoliform differentiation, in which DICER1 mutations are known to occur, to include Sertoli cell tumors and gynandroblastomas. Our results suggest that DICER1 mutations may not have a role in testicular sex cord-stromal tumorigenesis.

Repositorio de la producción científica de los profesionales de un hospital universitario / Repository of the scientific production of the professionals of an university hospital

El acceso a la información científica es un tema muy debatido en la actualidad. Se recopiló la producción científica de los profesionales del Hospital Provincial Docente Clinicoquirúrgico Saturnino Lora Torres de Santiago de Cuba para elaborar el diseño del repositorio institucional de acceso abierto, que respondió a los requerimientos de los tipos de contenidos generados por sus profesionales y las políticas para entrar en él. Se concluyó la primera etapa y se encuentra en fase de construcción la segunda(AU)

The access to the scientific information is a topic very debated at present. The scientific production of the professionals of Saturnino Lora Torres Teaching Provincial Clinical Surgical Hospital in Santiago de Cuba was compiled to elaborate the design of the open access institutional repository, which fulfilled the requirements of the types of contents generated by its professionals and the policies to work on it. The first stage was concluded and its second phase is being built(AU)

De bibliotecas médicas y bibliotecarios / From medical libraries and librarians

Se brinda una panorámica sobre el origen del Día del Bibliotecario Cubano, el surgimiento de las bibliotecas en Cuba, y la evolución histórica y situación actual de la primera biblioteca médica de la provincia de Santiago de Cuba, con énfasis en la labor de sus bibliotecarias desde su apertura hasta la fecha. Asimismo se abordan aspectos relacionados con los servicios ofrecidos en las bibliotecas de ciencias de la salud y las competencias que deben poseer sus bibliotecarios y documentalistas en el siglo XXI. Finalmente, se expresa el reconocimiento a aquellos compañeros que con tanto amor y dedicación iniciaron esta actividad, y facilitaron a los profesionales de ciencias de la salud del territorio el acceso a la información(AU)

An overview is provided of the origin of the Cuban Librarian´s Day, the emergence of libraries in Cuba, and the historical development and current situation of the first medical library in Santiago de Cuba province, with emphasis in the work of its librarians from their opening to date. Also aspects related to the services offered in the libraries of the health sciences and the competences that its librarians and documentalists should have in the XXI century are discussed. Finally, the recognition is expressed to those partners who began this activity with so much love and dedication, and they facilitated the professionals of health sciences of the territory the access to the information(AU)

Ética profesional: errores e implicaciones en la consulta y utilización de la información cientificotécnica / Professional ethics: mistakes and implications in the outpatient department and use of the scientific and technical information

La actividad que precisa la generación de conocimientos para la producción científica, implica un reto diario para el profesional de la información. En este artículo se realiza un acercamiento a la labor, la responsabilidad y el desempeño de este último ante la magnitud de implicaciones éticas y errores cometidos por los autores en sus escritos (muchos de ellos evitables), particularmente con respecto a la consulta y utilización de documentos publicados sobre la medicina y ramas afines(AU)

The activity which demands of knowledge for the scientific production, implies a daily challenge for the information professional. In this article an approach to the professional's work, responsibility and performance is presented, taking into account the magnitude of ethical implications and mistakes committed by the authors in their writings (many of them avoidable), particularly with regard to the outpatient department and the use of published documents on medicine and related branches(AU)

Utilización de las bases de datos biomédicas en la Biblioteca de la Facultad de Ciencias Médicas No 1 de Santiago de Cuba / Using biomedical databases at the Library of the Medical College No. 1 of Santiago de Cuba

Se realizó un estudio descriptivo y transversal sobre la utilización de las bases de datos biomédicas en la biblioteca de la Facultad de Ciencias Médicas No.1 de Santiago de Cuba, en el período de febrero a marzo de 2009. En la semana del 9 al 14 de este último mes se escogió a 138 usuarios que solicitaron los servicios de la sala de navegación: búsqueda bibliográfica, actualización de antivirus y consulta de los contenidos disponibles en la intranet, pues esa fue la semana de mayor afluencia al local. Solo 13,8 por cientohabían recibido cursos de adiestramiento para acceder a esas fuentes, 70,0 por ciento desconocían que existieran y 81,9 por ciento no las consultaban. Entre los principales problemas identificados se hallaban: disponer de una conexión defectuosa, no haber sido adiestrados por las bibliotecarias y contar con insuficiente tiempo de máquina. Se recomendó impartir cursos de alfabetización informacional para que lograsen satisfacer por sí mismos sus demandas de información en biomedicina

A descriptive and cross-sectional study on the use of biomedical databases at the library of the Medical College No.1 of Santiago de Cuba was conducted from February to March 2009. From March 9th to 14th, 138 users that requested services of the navigation room were selected: literature search, antivirus updating and references of the available contents on the intranet, because that was the busiest week of the room. Only 13,8 per cent had received training courses for access to those sources, 70,0 per cent were unaware of the existence of them, and 81,9 per cent were not using them. Among the main identified problems were a faulty connection, not having been trained by the librarians and not having enough time on the computer. It was recommended information literacy courses so that users are able to comply by themselves with their demands of information in biomedicine