Coumarin-Synthetic Methodologies, Pharmacology, and Application as Natural Fluorophore.

Coumarins are secondary metabolites made up of benzene and α-pyrone rings fused together that can potentially treat various ailments, including cancer, metabolic, and degenerative disorders. Coumarins are a diverse category of both naturally occurring as well as synthesized compounds with numerous biological and therapeutic properties. Coumarins as fluorophores play a key role in fluorescent labeling of biomolecules, metal ion detection, microenvironment polarity detection, and pH detection. This review provides a detailed insight into the characteristics of coumarins as well as their biosynthesis in plants and metabolic pathways. Various synthetic strategies for coumarin core involving both conventional and green methods have been discussed comparing advantages and disadvantages of each method. Conventional methods discussed are Pechmann, Knoevenagel, Perkin, Wittig, Kostanecki, Buchwald-Hartwig, and metal-induced coupling reactions such as Heck and Suzuki, as well as green approaches involving microwave or ultrasound energy. Various pharmacological applications of coumarin derivatives are discussed in detail. The structural features and conditions responsible for influencing the fluorescence of coumarin core are also elaborated.

Luminous Insights: Exploring Organic Fluorescent "Turn-On" Chemosensors for Metal-Ion (Cu+2, Al+3, Zn+2, Fe+3) Detection.

There are several metal ions that are vital for the growth of the environmental field as well as for the biological field but only up to the maximum limit. If they are present in excess, it could be hazardous for the human health. With the growing technology, a series of various detection techniques are employed in order to recognize those metal ions, some of them include voltammetry, electrochemical methods, inductively couples, etc. However, these techniques are expensive, time consuming, requires large storage, advanced instrumentation, and a skilled person to operate. So, here comes the need of a sensor and it is defined as a miniature device which detects the substance of interest by giving response in the form of energy change. So, from past few decades, many sensors have been formulated for detecting metal ions with some basic characteristics like selectivity, specificity, sensitivity, high accuracy, lower detection limit, and response time. Detecting various metal ions by employing chemosensors involves different techniques such as fluorescence, phosphorescence, chemiluminescence, electrochemical, and colorimetry. The fluorescence technique has certain advantages over the other techniques. This review mainly focuses on the chemosensors that show a signal in the form of fluorescence to detect Al+3, Zn+2, Cu+2, and Fe+3 ions.