Anti-Inflammatory and Antioxidant Activity of Titanium Dioxide Nanotubes Conjugated with Quercetin.

Inflammation is closely associated with cancer and leads to the formation of various malignancies. Quercetin is a naturally occurring flavonoid, with numerous pharmaceutical activities like anti-oxidant, anti-inflammatory, and anti-tumor effects. Due to its partial solubility in an aqueous solution, its consumption is limited. We recently showed the physicochemical characterization of titanium dioxide nanotubes (TNT) conjugated with quercetin and we found that quercetin conjugated with TNT enhances the anticancer activity in B16F10 cells and induced apoptosis. In the present study, we stimulated the efficiency of quercetin conjugated with titanium dioxide nanotubes and studies their anti-oxidant, anti-inflammatory activity. TNT conjugated with quercetin showed less cytotoxic effect towards RAW264.7 macrophages than quercetin alone. The inflammatory stimulation of RAW264.7 with LPS induced the pro-inflammatory cytokine IL-6 and inducible nitric synthase mRNA which were significantly inhibited by treating with TNT-Qu without causing any toxicity than quercetin and TNT alone. These results suggested that the potential of TNT conjugated with quercetin are better than quercetin and TNT alone and TNT may provide protection against inflammation by down regulating IL-6 and iNOS.

Role of thymus in health and disease.

The thymus is a primary lymphoid organ, essential for the development of T-cells that will protect from invading pathogens, immune disorders, and cancer. The thymus decreases in size and cellularity with age referred to as thymus involution or atrophy. This involution causes decreased T-cell development and decreased naive T-cell emigration to the periphery, increased proportion of memory T cells, and a restricted, altered T-cell receptor (TCR) repertoire. The changes in composition and function of the circulating T cell pool as a result of thymic involution led to increased susceptibility to infectious diseases including the recent COVID and a higher risk for autoimmune disorders and cancers. Thymic involution consisting of both structural and functional loss of the thymus has a deleterious effect on T cell development, T cell selection, and tolerance. The mechanisms which act on the structural (cortex and medulla) matrix of the thymus, the gradual accumulation of genetic mutations, and altered gene expressions may lead to immunosenescence as a result of thymus involution. Understanding the molecular mechanisms behind thymic involution is critical for identifying diagnostic biomarkers and targets for treatment help to develop strategies to mitigate thymic involution-associated complications. This review is focused on the consequences of thymic involution in infections, immune disorders, and diseases, identifying potential checkpoints and potential approaches to sustain or restore the function of the thymus particularly in elderly and immune-compromised individuals.

Role of Prostaglandins in Multiple Sclerosis.

Multiple sclerosis (MS) is an autoimmune demyelinating disorder with chronic inflammation in the central nervous system, manifested by both physical and cognitive disability. Neuroinflammation and neurodegeneration are the phenomena that appear in the central nervous system associated with various neurodegenerative disorders, including MS, Alzheimer's diseases, amyotrophic lateral sclerosis and Parkinson's disease. Prostaglandins are one of the major mediators of inflammation that exhibit an important function in enhancing neuroinflammatory and neurodegenerative processes. These mediators would help understand the pathophysiology of MS as the combination of antagonists or agonists of prostaglandins receptors could be beneficial during the treatment of MS. The present review focuses on the role played by different prostaglandins and the enzymes which produced them in the etiopathogenesis of MS.

Potential Therapeutic Applications of C-Phycocyanin.

BACKGROUND: Cancer and other disorders such as inflammation, autoimmune diseases and diabetes are the major health problems observed all over the world. Therefore, identifying a therapeutic target molecule for the treatment of these diseases is urgently needed to benefit public health. C-Phycocyanin (C-PC) is an important light yielding pigment intermittently systematized in the cyanobacterial species along with other algal species. It has numerous applications in the field of biotechnology and drug industry and also possesses antioxidant, anticancer, antiinflammatory, enhanced immune function, including liver and kidney protection properties. The molecular mechanism of action of C-PC for its anticancer activity could be the blockage of cell cycle progression, inducing apoptosis and autophagy in cancer cells. OBJECTIVES: The current review summarizes an update on therapeutic applications of C-PC, its mechanism of action and mainly focuses on the recent development in the field of C-PC as a drug that exhibits beneficial effects against various human diseases including cancer and inflammation. CONCLUSION: The data from various studies suggest the therapeutic applications of C-PC such as anti-cancer activity, anti-inflammation, anti-angiogenic activity and healing capacity of certain autoimmune disorders. Mechanism of action of C-PC for its anticancer activity is the blockage of cell cycle progression, inducing apoptosis and autophagy in cancer cells. The future perspective of C-PC is to identify and define the molecular mechanism of its anti-cancer, anti-inflammatory and antioxidant activities, which would shed light on our knowledge on therapeutic applications of C-PC and may contribute significant benefits to global public health.