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1.
Inorg Chem ; 2024 Sep 11.
Artículo en Inglés | MEDLINE | ID: mdl-39258888

RESUMEN

The development of materials with superior thermal insulation and flame retardancy is critical for industrial applications and daily life. Metal-organic framework (MOF)@poly(vinyl alcohol) (PVA) (MOF@PVA) aerogel composites have demonstrated remarkable thermal insulation and flame retardancy properties. In this work, MIL-53(Al) was directly mixed with PVA and formed by freeze-drying, and the influence of the pore structure on the thermal insulation and flame retardancy properties of the materials was investigated. The incorporated MIL-53(Al) nanoparticles introduced abundant micro- and mesopores, enhancing the complexity of the pore structure and improving the thermal insulation and flame retardancy properties of the aerogels. The directionally freeze-cast aerogel achieved a thermal conductivity of 0.040 W·mK-1, and maintained excellent thermal insulation ability even at 220 °C. Furthermore, the aerogel exhibited nonflammable and self-extinguishing characteristics. This environmentally friendly manufacturing method provides new ideas for the design of MOF-based composites, thereby expanding their application areas.

2.
Front Psychiatry ; 15: 1424966, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38988741

RESUMEN

Introduction: Borderline Personality Disorder (BPD) traits play a crucial role in the prognosis of psychiatric disorders, as well as in assessing risks associated with negativity and impulsivity. However, there is a lack of data regarding the distribution characteristics of BPD traits and symptoms within clinical populations. Methods: A total of 3015 participants (1321 males, 1694 females) were consecutively sampled from outpatients at the psychiatric and psycho-counseling clinics at the Shanghai Mental Health Center. BPD symptoms were assessed using a self-reported personality diagnostic questionnaire. Having BPD traits is defined as having five or more positive items in self-reported BPD characteristics. Participants were stratified into male and female groups, age groups, and diagnostic groups (schizophrenia, mood disorders, anxiety disorders). Exploratory factor analysis using principal components analysis was conducted. Three factors were identified: "F1: Affective Instability and Impulsivity", "F2: Interpersonal Unstable and Extreme Reactions", and "F3: Identity Disturbance". Results: Among 3015 participants, 45.9% of the patients self-reported BPD traits. Comparing of male and female patients, there was no statistically significant difference in the occurrence rate of BPD traits (χ2 = 1.835, p=0.176). However, in terms of symptoms, female patients reported more symptoms than male patients. Female patients also exhibited more pronounced features on F2 compared to male patients (t =-1.972, p=0.049). There is a general decrease in BPD traits, symptoms, and factors with increasing age. Specifically, the proportion of positive BPD traits is approximately halved before the age of 30 and decreases to around one-third after the age of 30. BPD traits were most common in the Mood Disorders group at 55.7%, followed by the Anxiety Disorders group at 44.4%, and Schizophrenia group at 41.5% (χ2 = 38.084, p<0.001). Discussion: Our study revealed the pervasive presence of BPD traits and symptoms among psychiatric outpatients, exhibiting distinctive distributions across gender, age, and diagnostic categories. These findings emphasize the significance of identifying and addressing BPD pathology in the clinical care of psychiatric outpatients.

3.
J Affect Disord ; 323: 55-61, 2023 02 15.
Artículo en Inglés | MEDLINE | ID: mdl-36435397

RESUMEN

BACKGROUND: Mild to moderate depressive disorder (DD), which accounts for much larger patient population, has been largely neglected in previous studies exploring the sleep quality of DD patients; in addition, most of these patients had comorbid insomnia. Thus, this study aimed to explore the effect of repetitive transcranial magnetic stimulation (rTMS) and agomelatine on sleep quality of adult patients with mild to moderate DD. METHODS: 100 participants were randomly divided into high-frequency rTMS group and sham rTMS group (n = 50 each). All patients were administered agomelatine simultaneously. Hamilton Depression Scale-17 Items (HAMD-17), Pittsburgh Sleep Index (PSQI), and polysomnography were used to evaluate the efficacy. Serum norepinephrine (NE), 5-hydroxytryptamine, brain-derived neurotrophic factor (BDNF), and melatonin were also determined. RESULTS: The HAMD-17 and PSQI scores in high-frequency rTMS group were lower than those in sham rTMS group at the 4th and 8th weekend after treatment (P < 0.05). Post-treatment total sleep time, sleep efficiency, and N3 percentage in high-frequency rTMS group were better than those in sham rTMS group (P < 0.05); while post-treatment sleep latency, awakening time, micro-awakening times, and N1 percentage were significantly less than those in sham rTMS group (P < 0.01). Post-treatment serum levels of NE and BDNF in high-frequency rTMS group were higher than those in sham rTMS group (P < 0.05). LIMITATIONS: Small sample size and short follow-up duration. CONCLUSION: The combination of high-frequency rTMS and agomelatine is effective in the treatment of mild to moderate DD, which can improve the sleep quality and increase the levels of some neurotransmitters and neurotrophic factors.


Asunto(s)
Trastorno Depresivo , Estimulación Magnética Transcraneal , Humanos , Adulto , Calidad del Sueño , Factor Neurotrófico Derivado del Encéfalo , Biomarcadores , Trastorno Depresivo/tratamiento farmacológico , Resultado del Tratamiento
5.
Chemphyschem ; 20(19): 2417-2433, 2019 10 02.
Artículo en Inglés | MEDLINE | ID: mdl-31342629

RESUMEN

Two-dimensional (2D) nanomaterials have drawn tremendous attention due to their unique physicochemical properties and promising applications in the fields of electronics, energy storage, and catalysis. Recently, the biomedicine community has gradually started to recognize the great potential of these nanostructured materials for biomedical applications - in particular those related to cancer therapy. In this review, we provide a brief overview of a few representative 2D nanomaterials, discuss their preparation strategies and physicochemical properties, and highlight their applications in cancer nanomedicine. We expect that this review will shed some light on the new opportunities associated with 2D nanomaterials for biomedical research.


Asunto(s)
Nanomedicina , Nanoestructuras/química , Neoplasias/tratamiento farmacológico , Investigación Biomédica , Humanos , Fototerapia
6.
Nano Lett ; 17(11): 6790-6801, 2017 11 08.
Artículo en Inglés | MEDLINE | ID: mdl-29058908

RESUMEN

Polydopamine (PDA) coating as a bioinspired strategy for nanoparticles (NPs) has been extensively applied in cancer theranostics. However, a cellular-level understanding of nano-biointeraction of these PDA-coated NPs (PDNPs), which drives the fate of them and acts as a critical step to determine their efficacy, still remains unknown. Herein, we utilized the representative mesoporous silica NPs (MSNs) to be coated with PDA and study their nano-bioactivities in cancer cells. HeLa cell line was utilized as a model in this study. The PDNPs were discovered to be internalized through three specific pathways, that is, Caveolae-, Arf6-dependent endocytosis, and Rab34-mediated macropinocytosis (55%, 20% and 37% of uptake inhibition by nystatin, Arf6 knockdown, and rottlerin, respectively). Autophagy-mediated accumulation of PDNPs in lysosomes was observed and the formed PDA shells shedded in the lysosomes. Almost 40% of the NPs were transported out of cells via Rab8/10- and Rab3/26-mediated exocytosis pathways at our tested level. On the basis of these results, a novel combined cancer treatment strategy was further proposed using drug-loaded MSNs-PDA by (i) utilizing naturally intracellular mechanism-controlled PDA shedding for organelle-targeted release of drugs in lysosomes to generate lysosome impairment and (ii) blocking the demonstrated exocytosis pathways for enhanced therapeutic efficacy.


Asunto(s)
Antineoplásicos/administración & dosificación , Portadores de Fármacos/metabolismo , Exocitosis , Indoles/metabolismo , Lisosomas/metabolismo , Nanopartículas/metabolismo , Neoplasias/tratamiento farmacológico , Polímeros/metabolismo , Animales , Antineoplásicos/uso terapéutico , Portadores de Fármacos/química , Endocitosis , Células HeLa , Humanos , Indoles/química , Ratones , Nanopartículas/química , Neoplasias/metabolismo , Pinocitosis , Polímeros/química , Dióxido de Silicio/química , Dióxido de Silicio/metabolismo
7.
Theranostics ; 7(7): 1990-2002, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-28638484

RESUMEN

The present work proposes a unique de-PEGylation strategy for controllable delivery of small interfering RNA (siRNA) using a robust lipid-polymer hybrid nanoparticle (NP) platform. The self-assembled hybrid NPs are composed of a lipid-poly(ethylene glycol) (lipid-PEG) shell and a polymer/cationic lipid solid core, wherein the lipid-PEG molecules can gradually dissociate from NP surface in the presence of serum albumin. The de-PEGylation kinetics of a series of different lipid-PEGs is measured with their respective NPs, and the NP performance is comprehensively investigated in vitro and in vivo. This systematic study reveals that the lipophilic tails of lipid-PEG dictate its dissociation rate from NP surface, determining the uptake by tumor cells and macrophages, pharmacokinetics, biodistribution, and gene silencing efficacy of these hybrid siRNA NPs. Based on our observations, we here propose that lipid-PEGs with long and saturated lipophilic tails might be required for effective siRNA delivery to tumor cells and gene silencing of the lipid-polymer hybrid NPs after systemic administration.


Asunto(s)
Productos Biológicos/farmacocinética , Portadores de Fármacos/química , Sistemas de Liberación de Medicamentos , Nanopartículas/química , Polietilenglicoles/metabolismo , ARN Interferente Pequeño/farmacocinética , Adenocarcinoma/tratamiento farmacológico , Animales , Productos Biológicos/administración & dosificación , Productos Biológicos/farmacología , Modelos Animales de Enfermedad , Portadores de Fármacos/administración & dosificación , Células Epiteliales/efectos de los fármacos , Células Epiteliales/metabolismo , Células HeLa , Xenoinjertos , Humanos , Macrófagos/efectos de los fármacos , Macrófagos/metabolismo , Ratones , Ratones Endogámicos C57BL , Nanopartículas/administración & dosificación , Polietilenglicoles/administración & dosificación , Células RAW 264.7 , ARN Interferente Pequeño/administración & dosificación , ARN Interferente Pequeño/farmacología , Resultado del Tratamiento
8.
Angew Chem Int Ed Engl ; 56(39): 11896-11900, 2017 09 18.
Artículo en Inglés | MEDLINE | ID: mdl-28640986

RESUMEN

Photothermal therapy (PTT) has shown significant potential for cancer therapy. However, developing nanomaterials (NMs)-based photothermal agents (PTAs) with satisfactory photothermal conversion efficacy (PTCE) and biocompatibility remains a key challenge. Herein, a new generation of PTAs based on two-dimensional (2D) antimonene quantum dots (AMQDs) was developed by a novel liquid exfoliation method. Surface modification of AMQDs with polyethylene glycol (PEG) significantly enhanced both biocompatibility and stability in physiological medium. The PEG-coated AMQDs showed a PTCE of 45.5 %, which is higher than many other NMs-based PTAs such as graphene, Au, MoS2 , and black phosphorus (BP). The AMQDs-based PTAs also exhibited a unique feature of NIR-induced rapid degradability. Through both in vitro and in vivo studies, the PEG-coated AMQDs demonstrated notable NIR-induced tumor ablation ability. This work is expected to expand the utility of 2D antimonene (AM) to biomedical applications through the development of an entirely novel PTA platform.


Asunto(s)
Rayos Infrarrojos , Neoplasias/terapia , Fototerapia/métodos , Puntos Cuánticos , Animales , Materiales Biocompatibles , Línea Celular Tumoral , Disulfuros/química , Oro/química , Grafito/química , Humanos , Ratones , Ratones Desnudos , Molibdeno/química , Fósforo/química , Polietilenglicoles/química , Análisis Espectral/métodos , Propiedades de Superficie , Ensayos Antitumor por Modelo de Xenoinjerto
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