RESUMEN
INTRODUCTION: Gastrointestinal polyps commonly affect the pediatric population. The commoner variety amongst these is the solitary rectal polyp. Juvenile polyposis coli (JPC) is rare, characterized by multiple polyps occurring throughout the gut. AIM: The role of cyclooxygenase-2 (COX-2) has been implicated in gastrointestinal tumorigenesis. We aimed to look at the clinicopathological spectrum of solitary vs juvenile polyposis and compare their differences in expression of COX-2 and p53. MATERIALS AND METHODS: We studied 38 polyps from eight cases of JPC, collected over the past 10 years along with 40 solitary rectal polyps (SRP). RESULTS: The size of polyps was significantly more in cases of JPC compared to SRP. Adenomatous change was observed significantly more often in JPC. COX-2 expression was also significantly higher in the JPC group compared to SRPs. All cases of JPC polyps with adenomatous change showed strong COX-2 expression. There was no significant difference in expression of p53 in the JPC and SRP groups. CONCLUSION: We observed significantly higher COX-2 expression in JPC. Establishment of the role of COX-2 in JPC will help us formulate chemopreventive therapies as an adjunct to its surgical management.
Asunto(s)
Carcinogénesis/genética , Ciclooxigenasa 2/biosíntesis , Poliposis Intestinal/congénito , Síndromes Neoplásicos Hereditarios/genética , Proteína p53 Supresora de Tumor/biosíntesis , Adolescente , Niño , Ciclooxigenasa 2/genética , Femenino , Regulación Neoplásica de la Expresión Génica , Humanos , Poliposis Intestinal/genética , Poliposis Intestinal/patología , Masculino , Síndromes Neoplásicos Hereditarios/patología , Proteína p53 Supresora de Tumor/genéticaRESUMEN
Teratomas are the most common congenital tumors, but teratomas of the nasopharynx are rare in neonates. The present report is about an 18-day-old girl child with a nasopharyngeal teratoma protruding from the oral cavity. The tumor almost completely obstructed the airways and necessitated immediate intervention. The tumor was successfully removed by the transpalatal route. Histological examination showed that it was a mature teratoma. The case with its related differential diagnosis is discussed here.
Asunto(s)
Obstrucción de las Vías Aéreas/etiología , Neoplasias Nasofaríngeas/congénito , Neoplasias Nasofaríngeas/complicaciones , Teratoma/congénito , Teratoma/complicaciones , Obstrucción de las Vías Aéreas/patología , Femenino , Humanos , Recién Nacido , Neoplasias Nasofaríngeas/patología , Pronóstico , Teratoma/patologíaRESUMEN
Inflammatory myofibroblastic tumor occurring at intra-abdominal sites in children can be confused with malignancy because of its large size and location. It is a tumor classified as 'intermediate' between benign and malignant, but usually benign, with a strong tendency for recurrence. Treatment is surgical excision. Here, we present a brief outline of three such cases presenting as abdominal mass in infants.
