[The establishment of the MPEL for carboxylic acid derivatives in the air of a work area by using mathematical models]. / Obosnovanie PDK nekotorykh proizvodnykh karbonovykh kislot v vozdukhe rabochei zony s ispol'zovaniem matematicheskikh modelei.

Reports of MACs for carboxylic acid derivatives as sodium methoxyacetate (SMOA), methyl chlorpropionate (MCP) and acetoacetic ether (AAE). SMOA shows low toxicity, no cumulation and specific action MCP demonstrates moderate toxicity, low cumulation no specific action in concentrations close to Limac. AAE presents toxicity low in oral usage and moderate when inhaled, low cumulation, no irritation and sensitization. Tentative safe level of injury and MAC estimated for the aforesaid substances together with toxicity parameters compared with the substances studied before allowed the authors to set the MAC of SMOA--10, MCP--2, AAE--10 mg/m3.

[Effects of different functional groups of phenylurea compounds on indices of their toxicity and MAC in the air of work areas]. / Vliianie razlichnykh funktsional'nykh grupp v soedineniiakh fenilmocheviny na pokazateli ikh toksichnosti i PDK v vozdukhe rabochei zony.

Free-Wilson technique with the use of computer correlation-regression and dispersion analysis program made it possible to determine the importance of certain radicals and functional groups for the characteristics of the toxicity of phenylurea compounds. Specific contribution of different functional groups depending on their position in the molecule to the values of toxicometric indices (LD50, Limac, Limch) and MAC of those compounds in the air of the working area were determined. Summary contributions of radicals with their functional groups to the values of toxicity indices and MACs for individual substances of the phenylurea group was calculated. A possibility was shown to use the Free-Wilson technique for the rapid prediction of toxicity and hygienic standards for new phenylurea compounds in the air of the working area.

[Use of the sum of molecular radicals in regression analysis for predicting the toxicity and MPEL of organophosphorus compounds]. / Ispol'zovanie summarnogo vklada radikalov molekuly v uravneniiakh regressii dlia prognozirovaniia toksichnosti i PDK fosfor- organicheskikh soedinenii.

The sum of the organophosphorous compounds' radicals, as calculated with the Free-Wilson technique, provides the most informative descriptor in toximetric indices calculations for these substances in correlation-regression analysis. The resulting formulae can be used in the planning procedures for experimental activities in hygienic standards of these substances and working area MAC's elaboration.

[Toxicology and hygienic standardization of the new insecticide neopinamine]. / Toksikologiia i gigienicheskoe normirovanie novogo insektitsida neopinamina.

Proceeding from the experimental study of neopinamine insecticide toxicity its hygienic standardization was carried out. Since neopinamine had moderate toxicity under its acute and chronic effect and different routes of body intake, its accumulation was absent and its impact was selective in the occurrence of aftereffects, this preparation was attributed to the third class of danger. Neopinamine MAC in the workplace air was recommended at the level of 5 mg/m3.

[Mathematical prediction of indicators of toxicity and hygienic standardization of phenylurea compounds]. / Matematicheskoe prognozirovbanie pokazatelei toksichnosti i gigienicheskikh normativov soedinenii riada fenilmocheviny.

The relation between physical and chemical constants and toxicometric indicators has been used as the basis of mathematical simulation both of separate indices of toxicity and preliminary safety exposure levels of the compounds of phenylurea series, thus it becomes possible to apply the derived mathematical links for rapid hygienic norm-setting of new substances of the above group. Multiple regression equations have been derived for calculating LD50, Limac, Limch and MACs of phenylurea in the work zone air. The proposed approach to MAC substantiation provides the opportunity to predict MACs for similar chemical compounds in the work zone air with sufficient accuracy.