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1.
Bernardete, Weber; Bersch, Ferreira  C; Torreglosa, Camila R; Marcadenti, Aline; Lara, Enilda S; Silva, Jaqueline T da; Costa, Rosana P; Santos, Renato H N; Berwanger, Otavio; Bosquetti, Rosa; Pagano, Raira; Mota, Luis G S; Oliveira, Juliana D de; Soares, Rafael M; Galante, Andrea P; Silva, Suzana A da; Zampieri, Fernando G; Kovacs, Cristiane; Amparo, Fernanda C; Moreira, Priscila; Silva, Renata A da; Santos, Karina G dos; Monteiro, Aline S5,; Paiva, Catharina C J; Magnoni, Carlos D; Moreira, Annie S; Peçanha, Daniela O; Missias, Karina C S; Paula, Lais S de; Marotto, Deborah; Souza, Paula; Martins, Patricia R T; Santos, Elisa M dos; Santos, Michelle R; Silva, Luisa P; Torres, Rosileide S; Barbosa, Socorro N A A; Pinho, Priscila M de; Araujo, Suzi H A de; Veríssimo, Adriana O L; Guterres, Aldair S; Cardoso, Andrea F R; Palmeira, Moacyr M; Ataíde, Bruno R B de; Costa, Lilian P S; Marinho, Helyde A; Araújo, Celme B P de; Carvalho, Helen M S; Maquiné, Rebecca O; Caiado, Alessandra C; Matos, Cristina H de; Barretta, Claiza; Specht, Clarice M; Onofrei, Mihaela; Bertacco, Renata T A; Borges, Lucia R; Bertoldi, Eduardo G; Longo, Aline; Ribas, Bruna L P; Dobke, Fernanda; Pretto, Alessandra D B; Bachettini, Nathalia P; Gastaud, Alexandre; Necchi, Rodrigo; Souza, Gabriela C; Zuchinali, Priccila; Fracasso, Bianca M; Bobadra, Sara; Sangali, Tamirys D; Salamoni, Joyce; Garlini, Luíza M; Shirmann, Gabriela S; Los Santos, Mônica L P de; Bortonili, Vera M S; Santos, Cristiano P dos; Bragança, Guilherme C M; Ambrózio, Cíntia L; Lima, Susi B E; Schiavini, Jéssica; Napparo, Alechandra S; Boemo, Jorge L; Nagano, Francisca E Z; Modanese, Paulo V G; Cunha, Natalia M; Frehner, Caroline; Silva, Lannay F da; Formentini, Franciane S; Ramos, Maria E M; Ramos, Salvador S; Lucas, Marilia C S; Machado, Bruna G; Ruschel, Karen B; Beiersdorf, Jâneffer R; Nunes, Cristine E; Rech, Rafael L; Damiani, Mônica; Berbigier, Marina; Poloni, Soraia; Vian, Izabele; Russo, Diana S; Rodrigues, Juliane; Moraes, Maria A P de; Costa, Laura M da; Boklis, Mirena; El Kik, Raquel M; Adorne, Elaine F; Teixeira, Joise M; Trescastro, Eduardo P; Chiesa, Fernanda L; Telles, Cristina T; Pellegrini, Livia A; Reis, Lucas F; Cardoso, Roberta G M; Closs, Vera E; Feres, Noel H; Silva, Nilma F da; Silva, Neyla E; Dutra, Eliane S; Ito, Marina K; Lima, Mariana E P; Carvalho, Ana P P F; Taboada, Maria I S; Machado, Malaine M A; David, Marta M; Júnior, Délcio G S; Dourado, Camila; Fagundes, Vanessa C F O; Uehara, Rose M; Sasso, Sandramara; Vieira, Jaqueline S O; Oliveira, Bianca A S de; Pereira, Juliana L; Rodrigues, Isa G; Pinho, Claudia P S; Sousa, Antonio C S; Almeida, Andreza S; Jesus, Monique T de; Silva, Glauber B da; Alves, Lucicna V S; Nascimento, Viviane O G; Vieira, Sabrina A; Coura, Amanda G L; Dantas, Clenise F; Leda, Neuma M F S; Medeiros, Auriene L; Andrade, Ana C L; Pinheiro, Josilene M F; Lima, Luana R M de; Sabino, L S; Souza, C V S de; Vasconcelos, S M L; Costa, F A; Ferreira, R C; Cardoso, I B; Navarro, L N P; Ferreira, R B; Júnior, A E S; Silva, M B G; Almeida, K M M; Penafort, A M; Queirós, A P O de; Farias, G M N; Carlos, D M O; Cordeiro, C G N C; Vasconcelos, V B; Araújo, E M V M C de; Sahade, V; Ribeiro, C S A; Araujo, G A; Gonçalves, L B; Teixeira, C S; Silva, L M A J; Costa, L B de; Souza, T S; Jesus, S O de; Luna, A B; Rocha, B R S da; Santos, M A; Neto, J A F; Dias, L P P; Cantanhede, R C A; Morais, J M; Duarte, R C L; Barbosa, E C B; Barbosa, J M A; Sousa, R M L de; Santos, A F dos; Teixeira, A F; Moriguchi, E H; Bruscato, N M; Kesties, J; Vivian, L; Carli, W de; Shumacher, M; Izar, M C O; Asoo, M T; Kato, J T; Martins, C M; Machado, V A; Bittencourt, C R O; Freitas, T T de; Sant'Anna, V A R; Lopes, J D; Fischer, S C P M; Pinto, S L; Silva, K C; Gratão, L H A; Holzbach, L C; Backes, L M; Rodrigues, M P; Deucher, K L A L; Cantarelli, M; Bertoni, V M; Rampazzo, D; Bressan, J; Hermsdorff, H H M; Caldas, A P S; Felício, M B; Honório, C R; Silva, A da; Souza, S R; Rodrigues, P A; Meneses, T M X de; Kumbier, M C C; Barreto, A L; Cavalcanti, A B.
Am. heart j ; 215: 187-197, Set. 2019. graf, tab
Artículo en Inglés | Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1023356

RESUMEN

Background Complex percutaneous coronary intervention (PCI) is associated with higher ischemic risk, which can be mitigated by long-term dual antiplatelet therapy (DAPT). However, concomitant high bleeding risk (HBR) may be present, making it unclear whether short- or long-term DAPT should be prioritized. Objectives This study investigated the effects of ischemic (by PCI complexity) and bleeding (by PRECISE-DAPT [PRE dicting bleeding Complications in patients undergoing stent Implantation and Sub sequent Dual Anti Platelet Therapy] score) risks on clinical outcomes and on the impact of DAPT duration after coronary stenting. Methods Complex PCI was defined as ≥3 stents implanted and/or ≥3 lesions treated, bifurcation stenting and/or stent length >60 mm, and/or chronic total occlusion revascularization. Ischemic and bleeding outcomes in high (≥25) or non-high (<25) PRECISE-DAPT strata were evaluated based on randomly allocated duration of DAPT. Results Among 14,963 patients from 8 randomized trials, 3,118 underwent complex PCI and experienced a higher rate of ischemic, but not bleeding, events. Long-term DAPT in non-HBR patients reduced ischemic events in both complex (absolute risk difference: −3.86%; 95% confidence interval: −7.71 to +0.06) and noncomplex PCI strata (absolute risk difference: −1.14%; 95% confidence interval: −2.26 to −0.02), but not among HBR patients, regardless of complex PCI features. The bleeding risk according to the Thrombolysis In Myocardial Infarction scale was increased by long-term DAPT only in HBR patients, regardless of PCI complexity. Conclusions Patients who underwent complex PCI had a higher risk of ischemic events, but benefitted from long-term DAPT only if HBR features were not present. These data suggested that when concordant, bleeding, more than ischemic risk, should inform decision-making on the duration of DAPT. (AU)


Asunto(s)
Humanos , Enfermedades Cardiovasculares/prevención & control , Evaluación Nutricional , Nutrición, Alimentación y Dieta
2.
Am Heart J ; 215: 187-197, 2019 09.
Artículo en Inglés | MEDLINE | ID: mdl-31349110

RESUMEN

BACKGROUND: Appropriate dietary recommendations represent a key part of secondary prevention in cardiovascular disease (CVD). We evaluated the effectiveness of the implementation of a nutritional program on quality of diet, cardiovascular events, and death in patients with established CVD. METHODS: In this open-label, multicenter trial conducted in 35 sites in Brazil, we randomly assigned (1:1) patients aged 45 years or older to receive either the BALANCE Program (experimental group) or conventional nutrition advice (control group). The BALANCE Program included a unique nutritional education strategy to implement recommendations from guidelines, adapted to the use of affordable and regional foods. Adherence to diet was evaluated by the modified Alternative Healthy Eating Index. The primary end point was a composite of all-cause mortality, cardiovascular death, cardiac arrest, myocardial infarction, stroke, myocardial revascularization, amputation, or hospitalization for unstable angina. Secondary end points included biochemical and anthropometric data, and blood pressure levels. RESULTS: From March 5, 2013, to Abril 7, 2015, a total of 2534 eligible patients were randomly assigned to either the BALANCE Program group (n = 1,266) or the control group (n = 1,268) and were followed up for a median of 3.5 years. In total, 235 (9.3%) participants had been lost to follow-up. After 3 years of follow-up, mean modified Alternative Healthy Eating Index (scale 0-70) was only slightly higher in the BALANCE group versus the control group (26.2 ±â€¯8.4 vs 24.7 ±â€¯8.6, P < .01), mainly due to a 0.5-serving/d greater intake of fruits and of vegetables in the BALANCE group. Primary end point events occurred in 236 participants (18.8%) in the BALANCE group and in 207 participants (16.4%) in the control group (hazard ratio, 1.15; 95% CI 0.95-1.38; P = .15). Secondary end points did not differ between groups after follow-up. CONCLUSIONS: The BALANCE Program only slightly improved adherence to a healthy diet in patients with established CVD and had no significant effect on the incidence of cardiovascular events or death.


Asunto(s)
Enfermedades Cardiovasculares/prevención & control , Dieta/normas , Programas Nacionales de Salud/normas , Evaluación Nutricional , Estado Nutricional , Desarrollo de Programa/métodos , Prevención Secundaria/métodos , Brasil/epidemiología , Enfermedades Cardiovasculares/epidemiología , Causas de Muerte/tendencias , Femenino , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Factores de Riesgo , Tasa de Supervivencia/tendencias
4.
Am Heart J ; 171(1): 73-81.e1-2, 2016 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-26699603

RESUMEN

This article reports the rationale for the Brazilian Cardioprotective Nutritional Program (BALANCE Program) Trial. This pragmatic, multicenter, nationwide, randomized, concealed, controlled trial was designed to investigate the effects of the BALANCE Program in reducing cardiovascular events. The BALANCE Program consists of a prescribed diet guided by nutritional content recommendations from Brazilian national guidelines using a unique nutritional education strategy, which includes suggestions of affordable foods. In addition, the Program focuses on intensive follow-up through one-on-one visits, group sessions, and phone calls. In this trial, participants 45 years or older with any evidence of established cardiovascular disease will be randomized to the BALANCE or control groups. Those in the BALANCE group will receive the afore mentioned program interventions, while controls will be given generic advice on how to follow a low-fat, low-energy, low-sodium, and low-cholesterol diet, with a view to achieving Brazilian nutritional guideline recommendations. The primary outcome is a composite of death (any cause), cardiac arrest, acute myocardial infarction, stroke, myocardial revascularization, amputation for peripheral arterial disease, or hospitalization for unstable angina. A total of 2468 patients will be enrolled in 34 sites and followed up for up to 48 months. If the BALANCE Program is found to decrease cardiovascular events and reduce risk factors, this may represent an advance in the care of patients with cardiovascular disease.


Asunto(s)
Enfermedades Cardiovasculares/prevención & control , Dieta/métodos , Programas Nacionales de Salud/normas , Evaluación Nutricional , Prevención Secundaria/métodos , Brasil/epidemiología , Enfermedades Cardiovasculares/epidemiología , Conducta Alimentaria , Humanos , Incidencia , Tasa de Supervivencia/tendencias
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