Unraveling athletic performance: Transcriptomics and external load monitoring in handball competition.

OBJECTIVE: This study aims to comprehend the impact of handball practice on sub-elite athletes by investigating transcriptomic changes that occur during a match. The primary focus encompasses a dual objective: firstly, to identify and characterize these transcriptomic alterations, and secondly, to establish correlations between internal factors (gene expression), and external loads measured through Electronic Performance and Tracking Systems (EPTS variables). Ultimately, this comprehensive analysis seeks to evaluate both acute and chronic responses to exercise within the context of handball training. METHODS: The study included sixteen elite male athletes from the FC Barcelona handball second team. Blood samples were extracted at three different time points: before the match at baseline levels (T1), immediately upon completion (T2), and 24 hours after completion (T3). Differential gene expression, Gene Ontology Term and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were conducted in two comparisons: Comparison 1 (T1 vs T2) and Comparison 2 (T1 vs T3). Further, the correlation between gene expression levels and training variables (external load) was conducted. RESULTS: In T1 vs T2, 3717 of the 14632 genes detected were differentially expressed (adjusted p-value < 0.05), and enrichment of terms related to the immune system, mitochondria, and metabolic processes was found. Further, significant linear correlations were obtained between High-Speed running (HSR) and high-intensity variables such as acceleration ACC and deceleration DEC values with amino acids, and inflammatory and oxidative environment-related pathways, both in chronic and acute response. CONCLUSIONS: This research highlights the effects of external workload on elite athletes during a handball match and throughout the season. The study identifies deregulation in the immune system, mitochondrial functions, and various metabolic pathways during the match. Additionally, it establishes correlations between the external load and pathways associated with amino acids, inflammation, oxidative environment, and regulation. These findings offer insights into the immediate and chronic responses of athletes to physical effort.

Recurrent Glioblastoma: A Review of the Treatment Options.

Glioblastoma is a disease with a poor prognosis. Multiple efforts have been made to improve the long-term outcome, but the 5-year survival rate is still 5-10%. Recurrence of the disease is the usual way of progression. In this situation, there is no standard treatment. Different treatment options can be considered. Among them would be reoperation or reirradiation. There are different studies that have assessed the impact on survival and the selection of patients who may benefit most from these strategies. Chemotherapy treatments have also been considered in several studies, mainly with alkylating agents, with data mostly from phase II studies. On the other hand, multiple studies have been carried out with target-directed treatments. Bevacizumab, a monoclonal antibody with anti-angiogenic activity, has demonstrated activity in several studies, and the FDA has approved it for this indication. Several other TKI drugs have been evaluated in this setting, but no clear benefit has been demonstrated. Immunotherapy treatments have been shown to be effective in other types of tumors, and several studies have evaluated their efficacy in this disease, both immune checkpoint inhibitors, oncolytic viruses, and vaccines. This paper reviews data from different studies that have evaluated the efficacy of different forms of relapsed glioblastoma.

Long term survival in multiple myeloma: a single institution experience in underprivileged circumstances.

There is data suggesting that the clinical behavior of multiple myeloma (MM) may be different in Latin Americans than in Caucasian or African-Americans, consistent with a less aggressive course of MM in Latinos. We analyzed the overall survival (OS) of 139 persons with MM in a single institution in México, as well the variables which were associated with long-term OS. Of all patients, the median OS was 11 years whereas the 5-year and 10-year OS were 75% and 55% respectively. The analysis of variables showed that the variable related with five-year survival was having hematopoietic stem cell transplantation (HSCT), whereas the variables related with 10-year survival were HSCT, age at diagnosis (patients younger than 50 survived longer), light chain type (kappa survived longer) and ISS stage (stage I patients survived longer). The only variable associated with both 5 and 10-year survival was HSCT. A plateau in the OS was reached after 10 years, both in grafted and non-grafted patients. We have confirmed the critical role of HSCT in the prognosis of persons with MM, independent of the induction treatment or the maintenance post-transplant, and we have identified a better prognosis in this cohort, as compared with African-Americans or Caucasians, since the proportion of long-term survivors in our group is seemingly better than those in other populations.

The effects of COVID-19 lockdown on jumping performance and aerobic capacity in elite handball players.

The aim of this research was to analyse the capacity of a home-based training programme to preserve aerobic capacity and jumping performance in top-level handball players during the COVID-19 lockdown. Eleven top-level male handball players from the same team participated in the study. A submaximal shuttle run test and a counter-movement jump test were used to measure the players' aerobic fitness and lower limb explosive strength, respectively. A 9-week home-based training programme was followed during lockdown. Pre-test measurements were assessed before the pandemic on 29 January 2020 and ended on 18 May 2020. Moderate significant mean heart rate increases were found in the late stages of the submaximal shuttle run test after the lockdown (stage 5, 8.6%, P = 0.015; ES = 0.873; stage 6, 7.7%, P = 0.020; ES = 0.886; stage 7, 6.4%, P = 0.019; ES = 0.827). Moderate significant blood lactate increases were observed immediately after the submaximal shuttle run test following the lockdown (30.1%, P = 0.016; ES = 0.670). In contrast, no changes were found in jump performance. A structured home-based training programme during the COVID-19 lockdown preserved lower limb explosive strength but was an insufficient stimulus to maintain aerobic capacity in top-level handball players.

Nasopharyngeal Panbio COVID-19 Antigen Performed at Point-of-Care Has a High Sensitivity in Symptomatic and Asymptomatic Patients With Higher Risk for Transmission and Older Age.

BACKGROUND: Performance of point-of-care tests in different clinical scenarios and on different samples remains undetermined. We comprehensively evaluated the performance of the nasopharyngeal Panbio COVID-19 Ag Rapid Test Device. METHODS: This is a prospective study that includes consecutive patients attending 3 primary care centers (PCCs) and an emergency department. The antigen test was performed at point-of-care in nasopharyngeal and nasal swabs and in saliva. Positive percent agreement (PPA) and negative percent agreement (NPA) were calculated with the reverse-transcription polymerase chain reaction (RT-PCR) assay as reference standard. RESULTS: Of 913 patients included, 296 (32.3%) were asymptomatic and 690 (75.6%) came from the PCC. Nasopharyngeal swabs were collected from 913 patients, nasal swabs were collected from 659 patients, and saliva was collected from 611 patients. The RT-PCR was positive in 196 (21.5%) nasopharyngeal samples (NPS). Overall, PPA (95% CI) in NPS was 60.5% (53.3-67.4), and it was lower in nasal swabs (44.7%) and saliva (23.1%). Test performance in NPS was largely dependent on the cycle threshold (Ct) in RT-PCR, with PPA of 94% for Ct ≤25 and 80% for Ct <30. In symptomatic patients, the PPA was 95% for Ct ≤25, 85% for Ct <30, and 89% for the symptom triad of fever, cough, and malaise. Performance was also dependent on age, with a PPA of 100% in symptomatic patients >50 years with Ct <25. In asymptomatic patients, the PPA was 86% for Ct <25. In all cases, NPA was 100%. CONCLUSIONS: The nasopharyngeal Panbio COVID-19 Ag test performed at point-of-care has a good sensitivity in symptomatic patients with Ct <30 and older age. The test was useful to identify asymptomatic patients with lower Ct values.

The DEAD-Box RNA Helicases of Bacillus subtilis as a Model to Evaluate Genetic Compensation Among Duplicate Genes.

The presence of duplicated genes in organisms is well documented. There is increasing interest in understanding how these genes subfunctionalize and whether functional overlap can explain the fact that some of these genes are dispensable. Bacillus subtilis possesses four DEAD-box RNA helicases (DBRH) genes, cshA, cshB, deaD/yxiN, and yfmL that make a good case to study to what extent they can complement each other despite their subfunctionalization. They possess the highly conserved N-terminal catalytic domain core common to RNA helicases, but different carboxy-terminal ends. All four genes have been shown to have independent functions although all participate in rRNA assembly. None of the B. subtilis DBRH is essential for growth at 37°C, and all single deletion mutants exhibit defective growth at 18°C except for ΔdeaD/yxiN. Evaluation of double mutants did not reveal negative epistasis, suggesting that they do not have overlapping functions. The absence of any one gene distorts the expression pattern of the others, but not in a specific pattern suggestive of compensation. Overexpression of these paralogous genes in the different mutant backgrounds did not result in cross-complementation, further confirming their lack of buffering capability. Since no complementation could be observed among full sized proteins, we evaluated to what extent the superfamily 2 (SF2) helicase core of the smallest DBRH, YfmL, could be functional when hooked to each of the C-terminal end of CshA, CshB, and DeaD/YxiN. None of the different chimeras complemented the different mutants, and instead, all chimeras inhibited the growth of the ΔyfmL mutant, and other combinations were also deleterious. Our findings suggest that the long time divergence between DEAD-box RNA helicase genes has resulted in specialized activities in RNA metabolism and shows that these duplicated genes cannot buffer one another.

Feed3: A Strategy for a 3-Direction Connection Among AT Consumers and Developers.

The Feed3 strategy aims to provide AT consumers, developers and manufacturers with Feedback, Feedforwards and FeedPeer mechanisms to collaborate in the development of novel accessible solutions. This strategy was developed as part of the GPII and it is currently adopted by the Unified Listing and DeveloperSpace infrastructure components.

Calidad de la información sobre el diagnóstico al paciente oncológico terminal / Quality of diagnosis information given to terminal cancer patients

OBJETIVO: Determinar la información que posee el paciente oncológico terminal sobre su diagnóstico, identificando las palabras utilizadas y cuantificando la conspiración de silencio. MÉTODO: Estudio analítico transversal a través de la revisión de la base de datos del equipo de soporte de cuidados paliativos donde constan los datos procedentes de la historia clínica y de una entrevista semiestructurada realizada a pacientes oncológicos terminales en una primera visita del equipo de soporte, incluyendo variables sociodemográficas y clínicas (diagnóstico oncológico, síntomas, número de síntomas, funcionalidad, calidad de vida y palabras utilizadas para la información). RESULTADOS: De una muestra final compuesta por 723 registros, el 77,87% (IC 95%: 74,70-80,74) presentó información sobre el diagnóstico. Las palabras más reportadas por los pacientes con las que describen los conocimientos del diagnóstico fueron: cáncer (26%), tumor (51,59%) e inflamación (10,65%). Se observó asociación entre la edad, el sexo, el diagnóstico de cáncer y el servicio de procedencia del paciente con la información sobre el diagnóstico que explicitaba. CONCLUSIONES: Los pacientes oncológicos terminales presentan conocimientos sobre su diagnóstico, generando que la conspiración de silencio se dé en un grado menor. Estos conocimientos son transmitidos utilizando diferentes palabras y con la presencia de eufemismos

AIM: To determine the information that terminal cancer patients have about their diagnosis, identifying key words used, and quantifying the conspiracy of silence. METHOD: A cross-sectional, analytical study was conducted by reviewing the hospice support team data base which contains the medical history and a semi-structured interview with terminal cancer patients in the first visit to the hospice. Demographic and socioeconomic data was collected, as well as relevant clinical information (diagnosis, prevalent symptoms, number of symptoms, patient functionality, QoL, information given, and words used). RESULTS: Out of total of sample of 723 records, 77.87% (95% CI: 74.70-80.74) of the patients were properly informed about their diagnosis. The most used words were cancer in 26% of the patients, tumour in 51.59%, and for the remaining 10.65%, the word inflammation was used. Statistically significant differences of information were found between sexes, age, types of cancer, and hospital ward. CONCLUSIONS: Terminal cancer patients have knowledge on their diagnosis, suggesting that the conspiracy of silence is present to a lesser extent. This knowledge is transmitted using different words and with euphemisms

[Quality of diagnosis information given to terminal cancer patients]. / Calidad de la información sobre el diagnóstico al paciente oncológico terminal.

AIM: To determine the information that terminal cancer patients have about their diagnosis, identifying key words used, and quantifying the conspiracy of silence. METHOD: A cross-sectional, analytical study was conducted by reviewing the hospice support team data base which contains the medical history and a semi-structured interview with terminal cancer patients in the first visit to the hospice. Demographic and socioeconomic data was collected, as well as relevant clinical information (diagnosis, prevalent symptoms, number of symptoms, patient functionality, QoL, information given, and words used). RESULTS: Out of total of sample of 723 records, 77.87% (95% CI: 74.70-80.74) of the patients were properly informed about their diagnosis. The most used words were cancer in 26% of the patients, tumour in 51.59%, and for the remaining 10.65%, the word inflammation was used. Statistically significant differences of information were found between sexes, age, types of cancer, and hospital ward. CONCLUSIONS: Terminal cancer patients have knowledge on their diagnosis, suggesting that the conspiracy of silence is present to a lesser extent. This knowledge is transmitted using different words and with euphemisms.

Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner.

SCOPE: Mice with deletion of insulin receptor substrate (IRS) 2 develop hyperglycaemia, impaired hepatic insulin signaling and elevated gluconeogenesis. Protein tyrosine phosphatase 1B (PTP1B) inhibition by resveratrol improves peripheral insulin sensitivity of these mice. Although resveratrol activates Sirtuin1 (Sirt1), the mechanisms underlying its beneficial effects are not totally elucidated. In this study, we have investigated whether Sirt1 mediates the effects of resveratrol in controlling insulin resistance in diabetic mice. METHODS AND RESULTS: We attempted to ameliorate peripheral insulin resistance in two diabetic models, Irs2-deficient (Irs2(-/-)) mice and streptozotocin (STZ)-injected mice by resveratrol treatment or Sirt1 overexpression. Resveratrol improved systemic insulin sensitivity of Irs2-deficient mice. Irs2-deficient mice are characterized by high levels of PTP1B expression in liver and muscle. Interestingly, resveratrol decreased PTP1B in both tissues, thereby restoring IRS1-mediated insulin signaling. Moreover, resveratrol also restored insulin sensitivity and hepatic insulin signaling in STZ-diabetic mice. In contrast, moderate overexpression of Sirt1 neither normalized PTP1B levels nor restored insulin signaling in Irs2-deficient mice or STZ-diabetic mice. CONCLUSION: Resveratrol improves peripheral insulin signaling independently of Sirt1 in diabetic mice in association with the inhibition of PTP1B and, therefore, this polyphenol could be an effective adjuvant for the treatment of diabetes.

Derivation and validation of a set of 10-year cardiovascular risk predictive functions in Spain: the FRESCO Study.

OBJECTIVE: To derive and validate a set of functions to predict coronary heart disease (CHD) and stroke, and validate the Framingham-REGICOR function. METHOD: Pooled analysis of 11 population-based Spanish cohorts (1992-2005) with 50,408 eligible participants. Baseline smoking, diabetes, systolic blood pressure (SBP), lipid profile, and body mass index were recorded. A ten-year follow-up included re-examinations/telephone contact and cross-linkage with mortality registries. For each sex, two models were fitted for CHD, stroke, and both end-points combined: model A was adjusted for age, smoking, and body mass index and model B for age, smoking, diabetes, SBP, total and HDL cholesterol, and for hypertension treatment by SBP, and age by smoking and by SBP interactions. RESULTS: The 9.3-year median follow-up accumulated 2973 cardiovascular events. The C-statistic improved from model A to model B for CHD (0.66 to 0.71 for men; 0.70 to 0.74 for women) and the combined CHD-stroke end-points (0.68 to 0.71; 0.72 to 0.75, respectively), but not for stroke alone. Framingham-REGICOR had similar C-statistics but overestimated CHD risk. CONCLUSIONS: The new functions accurately estimate 10-year stroke and CHD risk in the adult population of a typical southern European country. The Framingham-REGICOR function provided similar CHD prediction but overestimated risk.

Ergometría y cambio climático / Ergometry and climate change

Introducción y objetivosEn la corta historia de la ergometría moderna (50 años aprox.) se han producido notables cambios en la atmósfera que respiramos a nivel de grandes, medianas y pequeñas partículas; también a nivel de la composición gaseosa, con aumentos del gas carbónico (CO2) en torno al 125%. Esta situación se agrava dentro de los edificios, que es donde se ubican los laboratorios de fisiología del esfuerzo.El objeto del presente estudio fue comprobar cómo afectan estos cambios atmosféricos a los humanos durante el esfuerzo.MétodosSe realizó estudio comparativo mediante dos pruebas cicloergométricas, apareadas, en 13 sujetos (12♂+1♀). Una se hizo en la situación habitual del laboratorio (indoor) y la réplica se hizo en el mismo laboratorio, dentro de una burbuja con un sitema de filtrado de grandes, medianas y pequeñas partículas, tomando el aire del exterior del laboratorio, (aire libre, outdoor). Los parámetros que se controlaron fueron: la potencia máxima conseguida en el cicloergómetro y expresada en vatios (W), los parámetros ergoespirométricos (VO2max, VCO2max, VEmax), los parámetros cardiológicos: ritmo cardíaco por minuto y los niveles de ácido 2-hidroxipropanoico (La++) y la glicemia en sangre capilar arterializada.ResultadosNo se modificaron estadísticamente los parámetros ergoespirométricos, cardíacos, así como los relativos a la potencia alcanzada en el cicloergómetro, cuando comparamos las dos situaciones estudiadas. Sin embargo, los sujetos mostraron un mayor nivel de lactato arterial capilarizado (+117%) a los 3minutos de finalizar la prueba en situación indoor (7,55±1,81 vs 6,44±1,76mMol/dl; p<0,016; n=13).Idéntico comportamiento observamos en los niveles de glucosa en sangre capilar, que mostraron un incremento del 112% en la situación habitual (indoor) en comparación con los de la burbuja de aire purificado y exterior (glicemia: 90,0±12,2mg/dl vs 82,15±6,94mg/dl; p>0,054 no significativo; n=13)(AU)

DiscusiónLos analizadores de gases para estudio metabólico fueron capaces de calibrarse en diferentes atmósferas y determinar correctamente las capacidades y potenciales de estos sujetos, a pesar de los cambios atmosféricos. Las adaptaciones metabólicas fueron suficientes para compensar las diferencias atmosféricas comparadas y permitieron un nivel similar de prestaciones físicas expresadas en la prueba de esfuerzo y también en el comportamiento cardíaco expresado durante la misma atendiendo a los niveles de contaminación en un laboratorio cercano a Barcelona (NE spam).ConclusionesLos sujetos fueron capaces de adaptarse a los cambios atmosféricos debidos a la progresiva contaminación. No mostraron diferencias en las dos situaciones planteadas en el análisis metabólico de gases en esfuerzo, y tampoco hubo cambios en el comportamiento cardíaco. No se modificó la potencia máxima obtenida en el laboratorio. Pero metabólicamente se pagó un precio por la contaminación atmosférica, como muestra la mayor mobilización de glucosa en la sangre capilar y también en la mayor producción de lactato capilar en las condiciones del estudio(AU)

Introduction and objectivesIn the short history of ergonomics (approximately 50 years) there have been notable changes in the atmosphere that we breathe, such as large, medium and small particles, as well as the gas composition, with increases in carbon dioxide (CO2) of about 125%. This situation becomes worse within the buildings where the physiology exercise laboratories are located.The objective of this study was to determine how these atmospheric changes affect humans during exercise.MethodsA comparative study was conducted by means of 2 paired ergometric bicycle tests on 13 subjects (12 males and 1 female). One was carried out in the normal laboratory situation (indoor), and the repeat was done in the same laboratory, with a bubble with a system that filtered large, medium and small particles, breathing the air outside the laboratory (outdoor). The parameters that were controlled were: the maximum power achieved on the ergometric bicycle expressed in watts (W), the ergospirometer parameters (VO2max, VCO2max, VEmax), cardiological parameters: heart beats per minute and 2-hydroxypropanoic acid (La++) levels and arterialised capillary blood glucose.ResultsThe ergospirometer and cardiac parameters, or those associated with the power achieved on the ergometric bicycle did not change statistically, when we compared the two situations studied. However, the subjects did have higher levels of arterialised capillary lactate (+117%) 3min after finishing the indoor situation test (7.55±1.81 vs 6.44±1.76mMol/dl, P<0.016; n=13).We observed identical behaviour in the capillary blood glucose levels, which showed an increase of 112% in the usual situation (indoor) compared to those in the purified (outdoor) air bubble (blood glucose: 90.0±12.2mg/dl vs 82.15±6.94mg/dl; P>0.054 (not significant, n=13)(AU)

ConclusionsThe subjects were able to adapt to the atmospheric changes owing to the gradual contamination. No differences were seen in the two situations established in the metabolic gas analyses under effort, and neither were there any changes in cardiac behaviour. The maximum potential obtained in the laboratory did not change. But, metabolically, a price was paid for atmospheric contamination, as shown by the higher mobilisation of glucose in capillary blood, and also in the higher production of capillary lactate under the conditions of the study(AU)

Hipervitaminemia B12 por hipercobalofilinemia / B-12 hypervitaminosis due to hypercobalophylinemia

No disponible

Repercusiones en la salud pública de la resistencia a quinolonas en bacterias de origen animal / Implications on public health of quinolone resistance in bacteria of animal origin

Las fluoroquinolonas son una de las clases de agentes antimicrobianos más útiles empleadas hoy en día en medicina humana y animal debido a su espectro y a sus propiedades fisicoquímicas. El uso de quinolonas en animales es un asunto de especial preocupación porque podría contribuir a la adquisición de resistencia en bacterias transmitidas por alimentos (tales como Salomonella spp., Campylobacter spp. y Escherichia coli) y esto, a su vez, podría conducir a una reducción en la eficacia de tales componentes en el tratamiento de infecciones en los seres humanos. Sin embargo, la relación causal entre el uso de fluoroquinolonas en medicina veterinaria y el aislamiento de bacterias resistentes a fluoroquinolonas en humanos no ha sido generalmente probada y, además, el uso de fluoroquinolonas en animales es sólo uno de los muchos factores implicados en la resistencia a estos antimicrobianos. A pesar de ello, la vigilancia de la resistencia a fluoroquinolonas en bacterias aisladas de animales y alimentos y el uso adecuado de estos antimicrobianos en animales deben tener la máxima prioridad (AU)

No disponible

Estenosis esofágica benigna en pacientes lactantes y preescolares. Resultados de dilatación endoscópica / Benign esophageal strictures in toddlers and pre-school children. Results of endoscopic dilation

Antecedentes. La causa de disfagia en niños generalmente es condicionada por problemas benignos. Se requiere de una técnica segura y efectiva que se adecúe a lo reducido del diámetro en la luz orgánica, propio de la edad, para evitar iatrogenias del tipo de la perforación. Objetivo. Dar a conocer nuestra experiencia en el manejo de estenosis esofágicas benignas en pacientes lactantes y preescolares, mediante el uso de dilataciones con asistencia endoscópica. Material-Método y Resultados. Fueron evaluados en forma prospectiva 24 pacientes lactantes o preescolares con edad media de 3.5 años, portadores de estenosis esofágica, por un periodo de 3 años. La causa más común de la estenosis fue secundaria ingestión de cáusticos (grupo A) y en el grupo B se incluyeron otras causas. Las dilataciones se realizaron cada semana y se utilizaron dilatadores tipo Savary- Gilliard. La dilatación se consideró satisfactoria al lograr el paso del dilatador de 11 mm (33 Fr) con desaparición completa de la disfagia. De los 24 pacientes, 16 cursaron con estenosis por cáusticos, seis por complicaciones de enfermedad por reflujo, y los dos restantes por estenosis postoperatoria. Los pacientes del grupo A, cuando se compararon con el grupo B, requirieron mayor número de sesiones de dilatación (14.3 ñ 10.84 vs 7.0 ñ 2.94. p:>0.05 NS), presentaron menor tiempo libre de disfagia (1.1 ñ 0.39 meses vs 2.6 ñ 0.095. p<0.01) y cursaron con mayores recaídas (3.12 ñ 1.12 vs 1.25 ñ 0.95. p:<0.01). Se realizó un total de 292 sesiones de dilatación, dos pacientes cursaron con perforación esófagica y uno de ellos falleció. Conclusión. Las estenosis esofágicas benignas en niños pueden tratarse con aceptable seguridad mediante dilataciones endoscópicas. Se requiere de experiencia en el manejo de niños para evitar complicaciones

Enfermedad diverticular del colon / Diverticular disease of the colon

México ha sido considerado uno de los países con menor frecuencia de enfermedad ventricular del colon, lo que actualmente no parece real por ser la diverticulosis la lesión más aparentemente observada en los estudios radiológicos del colon. Se investigó en forma intencionada a 796 pacientes a los cuales se les había solicitado enema de bario, encontrando 96 casos de enfermedad diverticular, con una frecuencia de 16.9 por ciento en personas con edad superio a los 40 años, quienes en su mayoría consumían una dieta deficiente en fibra (88) y presentaban obesidad (40). Las complicaciones encontradas fueron hemorragia en 18.7 por ciento y diverticulitis aguda en 6.2 por ciento. Se analizó la etiopatogenia y discutió la utilidad de los exámenes de gabinete en el diagnóstico. Se concluye que esta enfermedad fue la lesión orgánica que más frecuentemente observamos en los enema de bario, probablemente debido a que los hábitos dietéticos están cambiando hacia una dieta pobre en fibra favorecedora de esta entidad; la diverticulitis aguda fue escasa en este estudio y la diverticulosis representó una causa frecuente de hemorragia profusa de tubo digestivo bajo