Features of Lipoperoxidation, Antioxidant Defense, and Thiol/Disulfide System in the Pathogenesis of Infertility in Males, Carriers of Nonfunctional Variants of GSTT1 and GSTM1 Gene Polymorphisms.

Comparative analysis of the parameters of LPO, antioxidant defense (AOD), and the thiol/disulfide system was performed in fertile and infertile males of reproductive age carrying different genotypes of the glutathione system genes. Blood plasma, blood hemolysate, and ejaculate served as specimens for biochemical studies. A decrease in glutathione S-transferase activity was found in blood and ejaculate specimens from fertile and infertile carriers of nonfunctional GSTT1(0/0)/GSTM1(0/0) genotypes. In infertile carriers of nonfunctional GSTT1(0/0)/GSTM1(0/0) genotypes determining reduced glutathione S-transferase activity, a decrease in the concentration of low-molecular-weight cell antioxidant (reduced glutathione) and an increase in the concentration of secondary LPO products (TBA-reactive substances) were revealed. Identification of carriers the polymorphic GSTT1 and GSTM1 variants and analysis of activity of the thiol/disulfide system enzymes can be recommended for additional evaluation of the risk for reproductive dysfunction in men.

[Impact of CPAP therapy on erectile function during sleep and testosterone level in men with sleep apnea syndrome].

The article presents the results of a polysomnographic study with simultaneous monitoring spontaneous nocturnal erections - Nocturnal Penile Tumescences (NPT) in 69 men with age-related androgen deficiency (AAD). Of these, 45 patients were diagnosed with obstructive sleep apnea syndrome (OSAS). In 34 of the 45 patients with OSAS, regimens of non-invasive ventilation with positive-positive airway pressure (CPAP) were selected. Titration was carried out using automatic CPAP-devices for 2 months. The control group (n=24) comprised men with AAD, matched by the "copy-pair" type without clinical manifestations of respiratory disturbances during sleep. Extreme fragmentation of sleep with a significant predominance of the 1st and 2nd stages of the slow sleep phase, the deficiency of deep sleep stages and the significant shortening of the fast sleep phase was leveled by using a constant positive pressure in the upper respiratory tract. CPAP-therapy produced the phenomenon of a "rebound" of slow-wave sleep and fast-sleep phase. Before treatment, men with OSAS had a disruptive pattern of NPT (quantitative and qualitative characteristics). CPAP-therapy resulted in its recovery and maximum preservation relative to fast sleep phase time boundaries. However, the trend towards increasing testosterone levels was not significant, which requires additional testosterone replacement therapy concurrently with CPAP therapy in patients with OSAS and AAD.

Effect of Preparation Based on Trametes Pubescens Xylotroph Fungi on Lipid Peroxidation in the Blood of Experimental Animals under Conditions of Dark Stress.

Using the model of dark stress caused by animal maintenance at dimmed light we showed that Trametin (product obtained during liquid-phase culturing of Trametes pubescens xylotroph fungi) effectively prevented oxidative stress under conditions of light deprivation. The preparation increased the level of unsaturation of lipids, reduced the concentration of primary and end-products of LPO, and increases both the integral parameter of the antioxidant defense system (total antioxidant activity) and its components (activity of superoxide dismutase and reduced glutathione).

Evaluation of myocardial energy parameters during simulation of epinephrine damage under conditions of cell transplantation.

The effects of transplantation of xenogenic neonatal heart cells on energy processes were studied in rat myocardium during the early period of epinephrine injury. Transplantation promoted a less pronounced ATP hydrolys to adenosine monophosphate and inorganic phosphate, a higher level of creatine phosphate, pyruvate, lactate, retention and activation of myocardial enzymes involved in energy metabolism.

[Spatial shifts in the receptive fields of neurons of the superficial layers of the superior colliculus of the cat during voluntary eye movements and head tilts]. / Prostranstvennye smeshchesniia retseptivnykh polei neironov poverkhnostnykh sloev verkhnego dvukholmiia koshek pri proizvol'nykh dvizheniiakh glaz i naklonakh golovy.

Receptive fields of 104 collicular neurons studied in alert cats have shifted their locations on the screen after saccades, induced by displacement of the point of fixation. Head tilt led to the same spatial tilt of preferred direction for directionally selective units. It is concluded that the studied part of visual system is not responsible directly for organization of constant spatial perception.