RESUMEN
Waldenström's macroglobulinemia is a rare disease with an indolent clinical course. The median age of the affected patient is 65 years. Nevertheless, we report a case of Waldenström's macroglobulinemia revealed by a splenomegaly and severe pancytopenia, in a 51-year-old man without previous medical history. According to the recent consensus recommendations for the clinicopathological definition of Waldenström's macroglobulinemia, diagnosis was made through morphological and immunophenotypic data of medullary cells. The reduced survival of the patient is associated with the importance of the cytopenia.
Asunto(s)
Macroglobulinemia de Waldenström/diagnóstico , Mapeo Cromosómico , Cromosomas Humanos Par 14 , Cromosomas Humanos Par 9 , Diagnóstico Diferencial , Humanos , Masculino , Persona de Mediana Edad , Pancitopenia/etiología , Esplenomegalia/etiología , Translocación Genética , Macroglobulinemia de Waldenström/sangre , Macroglobulinemia de Waldenström/genética , Macroglobulinemia de Waldenström/patologíaRESUMEN
INTRODUCTION: Cancer of the prostate in HIV-infected patients has rarely been reported in the literature. OBSERVATION: A 40 year-old man presented with an adenocarcinoma of the prostate and bone and glandular metastases. The patient exhibited HIV seropositivity stage B1, the immune-virology of which was well controlled by antiretroviral tritherapy. COMMENTS: The relationship between cancer and HIV has been established for certain cancers such as Hodgkin's disease, non-Hodgkin malignant lymphoma, Kaposi's sarcoma and invasive cancers of the uterine neck in women. The significant increase in some cancers in patients infected by HIV (lung, penis, soft tissue, lips, seminoma) suggests the potential association with immunodepression unless it corresponds to a risk induced by antiretroviral treatments in the long term.
Asunto(s)
Adenocarcinoma/complicaciones , Infecciones por VIH/complicaciones , Neoplasias de la Próstata/complicaciones , Adenocarcinoma/patología , Adulto , Humanos , Masculino , Metástasis de la Neoplasia , Neoplasias de la Próstata/etiología , Neoplasias de la Próstata/patologíaRESUMEN
INTRODUCTION: Cancer of the prostate in HIV-infected patients has rarely been reported in the literature. OBSERVATION: A 40-year-old man presented with an adenocarcinoma of the prostate and bone and glandular metastases. The patient exhibited HIV seropositivity stage B1, the immune-virology of which was well controlled by antiretroviral tritherapy. COMMENTS: The relationship between cancer and HIV has been established for certain cancers such as Hodgkin's disease, non-Hodgkin malignant lymphoma, Kaposi's sarcoma and invasive cancers of the uterine neck in women. The significant increase in some cancers in patients infected by HIV (lung, penis, soft tissue, lips, seminoma) suggests the potential association with immunodepression unless it corresponds to a risk induced by antiretroviral treatments in the long term.
Asunto(s)
Adenocarcinoma/secundario , Neoplasias Óseas/secundario , Infecciones por VIH/complicaciones , Neoplasias Glandulares y Epiteliales/secundario , Neoplasias de la Próstata/patología , Adenocarcinoma/virología , Adulto , Antivirales/uso terapéutico , Neoplasias Óseas/virología , Infecciones por VIH/tratamiento farmacológico , Humanos , Masculino , Neoplasias de la Próstata/virología , Factores de RiesgoAsunto(s)
Linfoma de Células B de la Zona Marginal/patología , Neoplasias de la Próstata/patología , Anciano , Anciano de 80 o más Años , Biomarcadores de Tumor/análisis , Células Clonales , ADN de Neoplasias/análisis , Diagnóstico Diferencial , Reordenamiento Génico de Cadena Pesada de Linfocito B/genética , Humanos , Queratinas/análisis , Antígeno Ki-67/análisis , Linfoma de Células B de la Zona Marginal/química , Linfoma de Células B de la Zona Marginal/cirugía , Masculino , Reacción en Cadena de la Polimerasa , Neoplasias de la Próstata/química , Neoplasias de la Próstata/cirugía , Prostatitis/patologíaAsunto(s)
Neoplasias de la Mama/diagnóstico , Carcinoma de Células Pequeñas/diagnóstico , Tumores Neuroendocrinos/diagnóstico , Anciano , Neoplasias de la Mama/patología , Neoplasias de la Mama/cirugía , Carcinoma de Células Pequeñas/patología , Carcinoma de Células Pequeñas/cirugía , Femenino , Humanos , Inmunohistoquímica , Índice Mitótico , Tumores Neuroendocrinos/patología , Tumores Neuroendocrinos/cirugíaRESUMEN
Sarcomas of the breast are relatively rare and account for 1% of all primary malignant tumors of the breast. Only 4 cases of pure chondrosarcoma of the breast have been published. We report an additional case in a fifty-seven-year-old woman. Histological and immunohistological characteristics were similar to those described in other localizations. Differential diagnosis involves cystosarcoma phyllodes and breast metaplastic carcinoma with chondroid differentiation. The prognosis is likely to be the same as in other chondrosarcomas.
Asunto(s)
Neoplasias de la Mama/patología , Condrosarcoma/patología , Neoplasias de la Mama/química , Condrosarcoma/química , Diagnóstico Diferencial , Femenino , Humanos , Inmunohistoquímica , Persona de Mediana Edad , PronósticoRESUMEN
Clear cell sarcoma (malignant melanoma of soft parts) is a rare malignancy that is found in the young adult, and is generally located in the extremities of the limbs. In this study, a new case has been reported in a 24-year old male with no previous history of cutaneous melanoma. The tumor consisted of fusiform or round cells with clear or granulocytic cytoplasm and vesicular nuclei. The patient was treated by surgical resection of the tumor and postoperative radiotherapy. Eight years later, metastatic nodes were detected in the inguinal region. The histogenesis of this tumor has not yet been determined, and it poses a diagnostic problem for pathologists as it can be mistaken for a malignant metastatic cutaneous melanoma.
Asunto(s)
Pierna , Sarcoma de Células Claras , Neoplasias de los Tejidos Blandos , Adulto , Terapia Combinada , Estudios de Seguimiento , Humanos , Metástasis Linfática , Masculino , Dosificación Radioterapéutica , Sarcoma de Células Claras/patología , Sarcoma de Células Claras/radioterapia , Sarcoma de Células Claras/cirugía , Neoplasias de los Tejidos Blandos/patología , Neoplasias de los Tejidos Blandos/radioterapia , Neoplasias de los Tejidos Blandos/cirugía , Factores de TiempoRESUMEN
Primary hypertrophic antro-pyloric stenosis in adults is a misleading anatomic and radioclinical entity. It consists of hypertrophy of the internal muscular layer. Distal gastrectomy is the only effective treatment of the symptomatic form and allows a pathologic study of the gastrectomy, thus ruling out most causes of obstruction, including neoplastic ones. Its congenital origin has not been established. We report the case of a 59 year-old man who had primary hypertrophic pyloric stenosis.
Asunto(s)
Obstrucción de la Salida Gástrica/patología , Estenosis Pilórica/patología , Adulto , Gastrectomía , Obstrucción de la Salida Gástrica/cirugía , Humanos , Hipertrofia , Masculino , Persona de Mediana Edad , Músculo Liso/patología , Estenosis Pilórica/cirugía , Píloro/patología , Estómago/patologíaRESUMEN
The pancreas is an uncommon site of metastasis for renal cell carcinoma. We report 2 cases of patients who underwent total and subtotal pancreatectomy 13 and 10 years after resection of the primary tumor. One of the patients already had liver and cerebellum metastasis, the second one had a solitary metastasis to the pancreas. In both cases, tumoral proliferation invaded the lumen of the Wirsung, and in one case was prominent through the papillae.