Surgical Techniques for Performing a Through-Knee Amputation: A Systematic Review and Development of an Operative Descriptive System.

BACKGROUND: Through-knee amputation (TKA) carries potential biomechanical advantages over above knee amputation (AKA) in patients unsuitable for a below-knee amputation. However, concerns regarding prosthetic fit, cosmesis and wound healing have tempered enthusiasm for the operation. Furthermore, there are many described surgical techniques for performing a TKA. This frustrates attempts to compare past and future comparative data, limiting the opportunity to identify which procedure is associated with the best patient centered outcomes. The aim of this systematic review is to identify all the recognized operative TKA techniques described in the literature and to develop a clear descriptive system to support future research in this area. METHODS: A systematic review was performed, searching the OVID, PubMed, and Cochrane Library databases, according to Cochrane and PRISMA guidelines. Papers of any design were included if they described an operative technique for a TKA. Key operative descriptions were captured and used to design a classification system for surgical techniques. RESULTS: A total of 906 papers were identified, of which 28 are included. The most important distinctions in operative technique were the level of division of the femur (disarticulation without bone division, transcondylar amputation, with or without shaving of the medial, lateral, and posterior condyles and supracondylar amputation), management of the patella (kept whole, partially preserved, completely removed), use of a muscular gastrocnaemius flap, and skin incisions. A 4-component classification system was developed to be able to describe TKA operative techniques. A suggested shorthand nomenclature uses the first letter of each component (FPMS; Femur, Patella, Muscular flap, Skin incision), followed by a number, to describe the operation. Patient outcomes were poorly reported, and therefore outcomes for different types of TKA are not addressed in this review. CONCLUSIONS: A novel descriptive system for describing different techniques for performing a TKA has been developed. This classification system will help in reporting, comparing, and interpreting past and future studies of patients undergoing TKA.

Systematic review and narrative synthesis of surgeons' perception of postoperative outcomes and risk.

BACKGROUND: The accuracy with which surgeons can predict outcomes following surgery has not been explored in a systematic way. The aim of this review was to determine how accurately a surgeon's 'gut feeling' or perception of risk correlates with patient outcomes and available risk scoring systems. METHODS: A systematic review was undertaken in accordance with PRISMA guidelines. A narrative synthesis was performed in accordance with the Guidance on the Conduct of Narrative Synthesis In Systematic Reviews. Studies comparing surgeons' preoperative or postoperative assessment of patient outcomes were included. Studies that made comparisons with risk scoring tools were also included. Outcomes evaluated were postoperative mortality, general and operation-specific morbidity and long-term outcomes. RESULTS: Twenty-seven studies comprising 20 898 patients undergoing general, gastrointestinal, cardiothoracic, orthopaedic, vascular, urology, endocrine and neurosurgical operations were included. Surgeons consistently overpredicted mortality rates and were outperformed by existing risk scoring tools in six of seven studies comparing area under receiver operating characteristic (ROC) curves (AUC). Surgeons' prediction of general morbidity was good, and was equivalent to, or better than, pre-existing risk prediction models. Long-term outcomes were poorly predicted by surgeons, with AUC values ranging from 0·51 to 0·75. Four of five studies found postoperative risk estimates to be more accurate than those made before surgery. CONCLUSION: Surgeons consistently overestimate mortality risk and are outperformed by pre-existing tools; prediction of longer-term outcomes is also poor. Surgeons should consider the use of risk prediction tools when available to inform clinical decision-making.

ANTECEDENTES: La precisión con la cual los cirujanos pueden predecir los resultados de la cirugía no se ha estudiado de forma sistemática. El objetivo de esta revisión fue determinar con qué precisión la intuición de un cirujano o su percepción del riesgo se correlacionaba con los resultados del paciente y con los sistemas de puntuación del riesgo disponibles. MÉTODOS: Se efectuó una revisión sistemática siguiendo las directrices PRISMA. Se realizó una síntesis narrativa de acuerdo con la guía para la realización de síntesis narrativas en revisiones sistemáticas. Se incluyeron los estudios que comparaban las evaluaciones preoperatorias o postoperatorias de los cirujanos respecto a los resultados de los pacientes. También se incluyeron aquellos estudios en los que se hacían comparaciones con herramientas de puntuación de riesgo. Se evaluaron la mortalidad postoperatoria, la morbilidad global y la morbilidad específica de las intervenciones, y los resultados a largo plazo. RESULTADOS: Se incluyeron 27 estudios con 20.898 pacientes en los que se realizaron procedimientos de cirugía general, digestiva, cardiotorácica, ortopédica, vascular, urológica, endocrina y neurocirugía. Los cirujanos predijeron consistentemente mayores tasas de mortalidad, siendo superados en precisión por los sistemas de estimación del riesgo existentes en seis de los siete estudios que utilizaron el área bajo la curva (area under curve, AUC) operativa del receptor. La predicción de la morbilidad general por parte de los cirujanos fue buena y era equivalente, incluso mejor, que los modelos de predicción de riesgos preexistentes. La capacidad de los cirujanos para predecir los resultados a largo plazo fue pobre, con una AUC que oscilaba entre 0,51 y 0,75. Cuatro de cinco estudios encontraron que las estimaciones de riesgo postoperatorias fueron más precisas que las realizadas preoperatoriamente. CONCLUSIÓN: Los cirujanos sobrestiman consistentemente el riesgo de mortalidad, siendo superados en precisión por las herramientas preexistentes. La predicción de resultados a largo plazo también es muy pobre. Los cirujanos deberían considerar el uso de herramientas de predicción de riesgo cuando estén disponibles para informar en el proceso de decisión clínica.

Observational study of the medical management of patients with peripheral artery disease.

BACKGROUND: Previous research has suggested that patients with peripheral artery disease (PAD) are not offered adequate risk factor modification, despite their high cardiovascular risk. The aim of this study was to assess the cardiovascular profiles of patients with PAD and quantify the survival benefits of target-based risk factor modification. METHODS: The Vascular and Endovascular Research Network (VERN) prospectively collected cardiovascular profiles of patients with PAD from ten UK vascular centres (April to June 2018) to assess practice against UK and European goal-directed best medical therapy guidelines. Risk and benefits of risk factor control were estimated using the SMART-REACH model, a validated cardiovascular prediction tool for patients with PAD. RESULTS: Some 440 patients (mean(s.d.) age 70(11) years, 24·8 per cent women) were included in the study. Mean(s.d.) cholesterol (4·3(1·2) mmol/l) and LDL-cholesterol (2·7(1·1) mmol/l) levels were above recommended targets; 319 patients (72·5 per cent) were hypertensive and 343 (78·0 per cent) were active smokers. Only 11·1 per cent of patients were prescribed high-dose statin therapy and 39·1 per cent an antithrombotic agent. The median calculated risk of a major cardiovascular event over 10 years was 53 (i.q.r. 44-62) per cent. Controlling all modifiable cardiovascular risk factors based on UK and European guidance targets (LDL-cholesterol less than 2 mmol/l, systolic BP under 140 mmHg, smoking cessation, antiplatelet therapy) would lead to an absolute risk reduction of the median 10-year cardiovascular risk by 29 (20-38) per cent with 6·3 (4·0-9·3) cardiovascular disease-free years gained. CONCLUSION: The medical management of patients with PAD in this secondary care cohort was suboptimal. Controlling modifiable risk factors to guideline-based targets would confer significant patient benefit.