[Traumatic abruption of the placenta with disseminated intravascular coagulation]. / Traumatische plazentalösung mit disseminierter intravasaler gerinnung.

Trauma in pregnancy is infrequent and a systematic primary strategy constitutes a real challenge for the interdisciplinary team. With a high fetal mortality rate and a substantial maternal mortality rate traumatic placental abruption is a severe emergency which every anesthetist should be aware of. After hemodynamic stabilization of the mother and control of the viability of the fetus the therapy of traumatic placental abruption consists mostly of an immediate caesarean section. Coagulopathy by depletion of coagulation factors as well as disseminated intravascular coagulation (DIC) have to be expected and consequently a massive blood loss must be anticipated. Thrombelastography provides assistance for fast differential diagnosis and goal-directed treatment of the disturbed sections of the coagulation cascade.

Automated mechanical ventilation: adapting decision making to different disease states.

The purpose of the present study is to introduce a novel methodology for adapting and upgrading decision-making strategies concerning mechanical ventilation with respect to different disease states into our fuzzy-based expert system, AUTOPILOT-BT. The special features are: (1) Extraction of clinical knowledge in analogy to the daily routine. (2) An automated process to obtain the required information and to create fuzzy sets. (3) The controller employs the derived fuzzy rules to achieve the desired ventilation status. For demonstration this study focuses exclusively on the control of arterial CO(2) partial pressure (p(a)CO(2)). Clinical knowledge from 61 anesthesiologists was acquired using a questionnaire from which different disease-specific fuzzy sets were generated to control p(a)CO(2). For both, patients with healthy lung and with acute respiratory distress syndrome (ARDS) the fuzzy sets show different shapes. The fuzzy set "normal", i.e., "target p(a)CO(2) area", ranges from 35 to 39 mmHg for healthy lungs and from 39 to 43 mmHg for ARDS lungs. With the new fuzzy sets our AUTOPILOT-BT reaches the target p(a)CO(2) within maximal three consecutive changes of ventilator settings. Thus, clinical knowledge can be extended, updated, and the resulting mechanical ventilation therapies can be individually adapted, analyzed, and evaluated.

Extubation after breathing trials with automatic tube compensation, T-tube, or pressure support ventilation.

BACKGROUND: Automatic tube compensation (ATC) is a new option to compensate for the pressure drop across the endotracheal or tracheostomy tube (ETT), especially during ventilator-assisted spontaneous breathing. While several benefits of this mode have so far been documented, ATC has not yet been used to predict whether the ETT could be safely removed at the end of weaning, from mechanical ventilation. METHODS: We undertook a systematic trial using a randomized block design. During a 2-year period, all eligible patients of a medical intensive care unit were treated with ATC, conventional pressure support ventilation (PSV, 5 cmH2O), or T-tube for 2-h. Tolerance of the breathing trial served as a basis for the decision to remove the endotracheal tube. Extubation failure was considered if reintubation was necessary or if the patient required non-invasive ventilatory assistance (both within 48 h). RESULTS AND CONCLUSIONS: After the inclusion of 90 patients (30 per group) we did not observe significant differences between the modes. Twelve patients failed the initial weaning trial. However, half of the patients who appeared to fail the spontaneous breathing trial on the T-tube, PSV, or both, were successfully extubated after a succeeding trial with ATC. Extubation was thus withheld from four and three of these patients while breathing with PSV or the T-tube, respectively, but to any patient breathing with ATC. It seems that ATC can be used as an alternative mode during the final phase of weaning from mechanical ventilation. Furthermore, this study may promote a larger multicenter trial on weaning with ATC compared with standard modes.

Automatic tube compensation (ATC).

Automatic tube compensation (ATC) is a new option to compensate for the non-linearly flow-dependent pressure drop across an endotracheal or tracheostomy tube (ETT) during inspiration and expiration. ATC is based on a closed-loop working principle. ATC is not a true ventilatory mode but rather a new option which can be combined with all conventional ventilatory modes. ATC compensates for the tube-related additional work of breathing. As of yet, ATC has been associated with certain benefits for the tracheally intubated spontaneously breathing patient. Among these, reduced work of breathing, preservation of the natural "noisy" breathing pattern, enhanced synchronization between the patient and the ventilator, and improvement of respiratory comfort seem to be most important. Moreover, sufficient spontaneous breathing with ATC alone, i.e. without any additional ventilatory assist, might help to predict more accurately readiness for extubation in the last phase of weaning from mechanical ventilation. Furthermore, it has been shown in patients with acute lung injury that ATC unloaded the inspiratory muscles and increased alveolar ventilation without adversely affecting cardiorespiratory function. It is the purpose of this article to describe the working principle of ATC and to give a review of the actual scientific discussion concerning ATC.

Automatic tube compensation.

In this article automatic tube compensation (ATC) is described with respect to working principle, to technical realization, and to clinical experience. ATC, based on an indirect closed-loop working principle, compensates for the flow-dependent pressure drop across the tracheal tube during both inspiration and expiration. ATC reduces patient work of breathing, increases respiratory comfort, and allows prediction of successful extubation. ATC is not a stand-alone ventilatory mode, but rather a component of flow-proportional pressure support that can be combined with all conventional ventilatory modes.

Breathing pattern and perception at different levels of volume assist and pressure support in volunteers.

OBJECTIVE: Volume assist (VA) amplifies the breathing effort whereas pressure support ventilation (PSV) provides a fixed, effort-independent ventilatory support. According to the concept of VA, its level should compensate for the pathologically increased (additional) elastance (Eadd). However, it is unclear whether breathing subjects prefer an exact compensation of Eadd and whether they are able to adjust the support level by themselves. DESIGN: Prospective, interventional study. SETTING: Laboratory. SUBJECTS: Twelve healthy volunteers, nine females, three males, aged 21-33 yrs. INTERVENTIONS: Increased Eadd was generated by banding of the thorax and abdomen. Volunteers breathed via a mouthpiece with VA or PSV using a positive end-expiratory pressure of 5 cm H2O (0.5 kPa). The study was subdivided into two parts. In part I, volunteers were instructed to adjust the level of VA and PSV themselves starting from three different, randomly applied levels in each mode (2, 8, 14 cm H2O or cm H2O/L; 0.2, 0.8, 1.4 kPa[/L]). In part II, 20 levels of VA and PSV (1-20 cm H2O or cm H2O/L, 0.1-2 kPa[/L]) were randomly selected by an investigator and estimated by the volunteers using a visual analog scale. Additionally, the breathing pattern was characterized. MEASUREMENTS AND MAIN RESULTS: Eadd (7.1 +/- 1.5 cm H2O/L [0.7 +/- 0.2 kPa/L], mean +/- sd) corresponded almost exactly to the "self-adjusted" VA level of part I (7.0 +/- 3.3 cm H2O/L [0.7 +/- 0.3 kPa/L]) and to the adequate level of part II (8-9 cm H2O/L [0.8-0.9 kPa/L]). The accordant PSV levels were 5.7 +/- 2.6 cm H2O (0.6 +/- 0.3 kPa) and 6-7 cm H2O (0.6-0.7 kPa). The breathing pattern was less influenced by changes of the support level with VA compared with PSV, which may explain in part the greater comfort of VA. CONCLUSIONS: We confirmed the theoretical assumption that VA should be adapted to Eadd. Furthermore, we demonstrated that conscious subjects are able to adjust the level of VA and PSV themselves.

[Automatic tube compensation (ATC)]. / Automatische Tubuskompensation (ATC).

The endotracheal tube (ETT) is a considerably flow-dependent and, therefore, variable mechanical load. Conventional modes of respiratory support cannot adequately compensate for the tube resistance in inspiratorion and not at all in expiration. Automatic tube compensation (ATC) compensates for the flow-dependent pressure drop across the tracheal tube by a positive pressure support in inspiration and by a negative pressure support in expiration. The pressure support closely follows the nonlinear pressure-flow curve of the ETT. Automatic tube compensation has an indirect closed-loop working principle since the target tracheal pressure is not directly measured but rather calculated from continuously measured airway pressure and flow rate. It is not an own ventilatory mode but rather a component of flow-proportional pressure support which can be combined with all conventional ventilatory modes, and provides a rational basis for subdividing the pressure support to overcome the mechanical load of the tubing and to overcome that of the respiratory system. Partial tube obstructions, which could decrease the effectivity of ATC, could be detected automatically by analysing the expiratory flow signal using a software, which could be easily implemented into the ventilator. The effectivity of ATC during long-term application can be maintained by intermittent short-term measurement of the tracheal pressure. Up to now there is no commercially available ventilator which allows complete expiratory ATC. Studies in volunteers and in mechanically ventilated patients have convincingly shown that ATC reduces work of breathing and increases respiratory comfort. In addition, successful extubation could be better predicted with this mode in difficult-to-wean patients compared to other modes. There are no special rules in the clinical application of ATC. However, to prevent overassist the support level of the ventilatory mode which is combined with ATC should be reduced.

Intensive care unit admission in patients with haematological disease: incidence, outcome and prognostic factors.

OBJECTIVES: To examine incidence and outcome of intensive care unit (ICU) admission in patients with haematological malignancy and analyse prognostic factors associated with outcome. DESIGN: Retrospective cohort study in an intensive care unit of a tertiary referral center. PATIENTS: 78 patients with severe haematological malignancy were admitted 97 times between 1990-97 to the medical ICU for septic shock (18), respiratory failure (30), postoperative monitoring (19), cardiovascular (10) and central nervous complications (8) or for other reasons (12). Median age was 43 (4-73) years, average duration of ICU stay was 4 (1-43) days. Forty-two patients required mechanical ventilation, 46 vasopressors and 8 haemodialysis. RESULTS: Rates of ICU admission differed by treatment of the underlying disease. There were 18, 10 and 27 ICU admissions per 100 treatments in patients undergoing chemotherapy for acute leukaemia, autologous and allogeneic stem cell transplantation (p <0.005) respectively. Thirty-two of 78 patients died within 60 days of ICU admission. Organ failure, i.e. cardiovascular failure requiring vasopressors, respiratory failure requiring mechanical ventilation and renal failure, requiring haemodialysis, was most significantly associated with outcome. Mortality by day 60 after admission was 16%, 36%, 64%, and 83% (p <0.0002) for patients without organ failure, and for patients with 1, 2 or 3 failing organs. In a multivariate logistical regression model, only the organ failure score (p <0.0005) and evidence of liver damage, defined as ASAT or ALAT >100 IU/ L (p <0.007), but not age, sex, primary disease and treatment of the underlying disease predicted outcome. CONCLUSION: Multi-organ failure and evidence of liver damage but no other patient, disease, or treatment related factor predict outcome in patients with haematological disease admitted to the ICU.

Total versus tube-related additional work of breathing in ventilator-dependent patients.

BACKGROUND: In tracheally intubated or tracheostomized spontaneously breathing patients, tube resistance can highly increase the patient's work of breathing. In this study we focused upon the relationship between total (WOBtot) and tube-related additional inspiratory work of breathing (WOBadd) and compared different ventilatory modalities for proper tube compensation. METHODS: In ten tracheostomized spontaneously breathing patients we measured WOBtot and WOBadd in the continuous positive airway pressure (CPAP) mode, under inspiratory pressure support of 5, 10, and 15 cmH2O in the pressure support ventilation (PSV) mode, and under flow-adjusted pressure support in the automatic tube compensation (ATC) mode. WOBadd and WOBtot were calculated on the basis of measured tracheal pressure and esophageal pressure, respectively. Inspiratory peak tracheal pressure above PEEP was taken as an estimate of pressure support beyond mere tube compensation (i.e., overcompensation). RESULTS: The percentage of the tube-related WOBadd on WOBtot in the CPAP mode was 52%. It decreased with increasing pressure support in the PSV mode from 32% (PSV 5 cmH2O) to 17% (PSV 15 cmH2O). WOBadd was only 15% of WOBtot in the ATC mode. In contrast to the other ventilatory modes, reduction of WOBadd in the ATC mode was achieved with the smallest amount of overcompensation, i.e. with minimal pressure assist beyond mere tube compensation. CONCLUSION: In tracheally intubated or tracheostomized spontaneously breathing patients, adequate compensation of tube resistance (i.e. with minimal overcompensation and minimal undercompensation) is best done by the ATC mode.

Respiratory comfort and breathing pattern during volume proportional assist ventilation and pressure support ventilation: a study on volunteers with artificially reduced compliance.

OBJECTIVE: To assess respiratory comfort and associated breathing pattern during volume assist (VA) as a component of proportional assist ventilation and during pressure support ventilation (PSV). DESIGN: Prospective, double-blind, interventional study. SETTING: Laboratory. SUBJECTS: A total of 15 healthy volunteers (11 females, 4 males) aged 21-31 yrs. INTERVENTIONS: Decreased respiratory system compliance was simulated by banding of the thorax and abdomen. Volunteers breathed via a mouthpiece with VA and PSV each applied at two levels (VA, 8 cm H2O/L and 12 cm H2O/L; PSV, 10 cm H2O and 15 cm H2O) using a positive end-expiratory pressure of 5 cm H2O throughout. The study was subdivided into two parts. In Part 1, volunteers breathed three times with each of the four settings for 2 mins in random order. In Part 2, the first breath effects of multiple, randomly applied mode, and level shifts were studied. MEASUREMENTS AND MAIN RESULTS: In Part 1, the volunteers were asked to estimate respiratory comfort in comparison with normal breathing using a visual analog scale. In Part 2, they were asked to estimate the change of respiratory comfort as increased, decreased, or unchanged immediately after a mode shift. Concomitantly, the respiratory pattern (change) was characterized with continuously measured tidal volume, respiratory rate, pressure, and gas flow. Respiratory comfort during VA was higher than during PSV. The higher support level was less important during VA but had a major negative influence on comfort during PSV. Both modes differed with respect to the associated breathing pattern. Variability of breathing was higher during VA than during PSV (Part 1). Changes in respiratory variables were associated with changes in respiratory comfort (Part 2). CONCLUSIONS: For volunteers breathing with artificially reduced respiratory system compliance, respiratory comfort is higher with VA than with PSV. This is probably caused by a better adaptation of the ventilatory support to the volunteer's need with VA.

Continuous calculation of intratracheal pressure in the presence of pediatric endotracheal tubes.

OBJECTIVE: To measure the pressure-flow relationship of pediatric endotracheal tubes (ETTs) in trachea models, to mathematically describe this relationship, and to evaluate in trachea/lung models a method for calculation of pressure at the distal end of the ETT (Ptrach) by subtracting the flow-dependent pressure drop across the ETT from the airway pressure measured at the proximal end of the ETT. DESIGN: Trachea models and trachea/lung models. SETTING: Research laboratory in a university medical center. INTERVENTIONS: The pressure-flow relationship of pediatric ETTs (inner diameter, 2.5-6.5 mm) was determined using a physical model consisting of a tube connector, an anatomically curved ETT, and an artificial trachea. The model was ventilated with sinusoidal gas flow (12-60 cycles/min). The coefficients of an approximation equation considering ETT resistance and inertance were fitted separately to the measured pressure-flow curves for inspiration and expiration. Calculated Ptrach was compared with directly measured Ptrach in mechanically ventilated physical trachea/lung models. MEASUREMENTS AND MAIN RESULTS: The pressure-flow relationship was considerably nonlinear and showed hysteresis around the origin caused by the inertia of accelerated gas. ETT inertance ranged from 0.1 to 0.4 cm H2O/L x sec2 (inner diameter, 6-2.5 mm). The abrupt change in cross-sectional area at the tube connector caused an inspiration-to-expiration asymmetry. Calculated and measured Ptrach were within +/- 1 cm H2O. Correspondence between measured and calculated Ptrach is improved even further when the ETT inertance is taken into account. CONCLUSIONS: Ptrach can continuously be monitored in the presence of pediatric ETT by combining ETT coefficients and the flow and airway pressure continuously measured at the proximal end of the ETT.

Breathing pattern associated with respiratory comfort during automatic tube compensation and pressure support ventilation in normal subjects.

BACKGROUND: Automatic tube compensation (ATC) is a new option to support spontaneously breathing tracheally intubated patients. We have previously demonstrated an increased respiratory comfort compared to pressure support ventilation (PSV) in volunteers. Here we characterized the breathing pattern during ATC associated with respiratory comfort in comparison to PSV. Furthermore, we studied whether ATC can be substituted by a simple modification of PSV. METHODS: We exposed 10 volunteers breathing through a 7.5 mm endotracheal tube via mouthpiece to PSV with 1) immediate and 2) delayed pressure rise and to 3) ATC. Immediate changes of the respiratory pattern after mode shifts were analyzed in detail. Furthermore, the volunteers were instructed to indicate changes in comfort after transitions between these modes as increased, unchanged, or decreased. RESULTS: Decreased comfort was associated with a substantial increase of tidal volume, minute ventilation, gas flow, and pressure. No differences in respiratory comfort were perceived between immediate and delayed pressure rise during PSV. CONCLUSION: PSV resulted in excessive tidal volumes and airflow, which was perceived as discomfort. This cannot be avoided by a delayed pressure rise but can be by the more comfortable ATC. ATC seems to adapt better to the ventilatory demand than PSV.

Interrupter airway and tissue resistance: errors caused by valve properties and respiratory system compliance.

The interrupter technique is used to determine airway and tissue resistance. Their accuracy is influenced by the technical properties of the interrupter device and the compliance of the respiratory system. We investigated the influence of valve characteristics and respiratory system compliance on the accuracy of determining airway and tissue resistance by means of a computer simulation. With decreasing compliance we found increasing errors in both airway and tissue resistance determination of up to 34 and 71%, respectively. On this basis we developed a new occlusion valve, with special emphasis on rapid closing time and tightness in the closed state to improve the accuracy of resistance determination. The newly developed occlusion device greatly improves the accuracy of airway and tissue resistance determination. We conclude that respiratory system compliance is a limiting factor for the accuracy of the interrupter technique. To apply the interrupter technique in patients with extremely low respiratory system compliances, we need sophisticated technical devices.

Dynamic delay time compensation for sampling capillaries used in respiratory mass spectrometry.

In intensive care patients who receive ventilatory support or full mechanical ventilation, valuable information can be drawn from gas exchange measurements. In this setting, the most favorable method for gas exchange measurement is by simultaneous recording of gas concentrations and gas flow, and by time resolved multiplication and accumulation. This paper presents a new method to compensate for the signal delay time which occurs when a sampling capillary is used for measuring gas concentrations with a respiratory mass spectrometer or some equivalent sidestream gas analyzer. The signal delay of gas concentrations must be accurately compensated to avoid error accumulation in gas exchange calculation. A delay time can be easily measured with a test gas in a laboratory setup and be readily compensated for during the measurements in a ventilated patient. This is a standard procedure which gives reasonable results under normal conditions. Special attention is however required in cases where the gas viscosity changes due to large changes in gas composition, e.g., those used for diagnostic breathing or ventilatory maneuvers. Such changes of viscosity will influence the delay time of the capillary, because they affect its flow resistance. As a consequence they will degrade the quality of measurements when done with a simple fixed delay compensation. The method described here consists of an algorithm which enables compensation for such a temporally changing delay time due to changes in gas composition.

Additional inspiratory work of breathing imposed by tracheostomy tubes and non-ideal ventilator properties in critically ill patients.

OBJECTIVE: To determine the tracheostomy tube-related additional work of breathing (WOBadd) in critically ill patients and to show its reduction by different ventilatory modes. DESIGN: Prospective, clinical study. SETTING: Medical ICU of a university teaching hospital. INTERVENTION: Standard tracheostomy due to prolonged respiratory failure. MEASUREMENTS AND RESULTS: Ten tracheostomized, spontaneously breathing patients were investigated. As the tube resistance depends on gas flow, patients were subdivided according to minute ventilation into a low ventilation group (= 10 l/min; n = 5) and a high ventilation group (> 10 l/min; n = 5). The WOBadd due to tube resistance and non-ideal ventilator properties was calculated on the basis of the tracheal pressure measured. Ventilatory modes investigated were: continuous positive airway pressure (CPAP), inspiratory pressure support (IPS) of 5, 10, and 15 cm H2O above PEEP, and automatic tube compensation (ATC). In the low ventilation group, WOBadd during CPAP was 0.382+/-0.106 J/l. It was reduced to below 15% of that value by ATC or IPS more than 5 cm H2O. In the high ventilation group WOBadd during CPAP increased to 0.908+/-0.142 J/l. In this group, however, only ATC was able to reduce WOBadd below 15% of the value observed in the CPAP mode. CONCLUSIONS: The results indicate that, depending on respiratory flow rate, (1) tracheostomy tubes can cause a considerable amount of WOBadd, and (2) ATC, in contrast to IPS, is a suitable mode to compensate for WOBadd at any ventilatory effort of the patient.

Effect of beta blockade with and without sympathomimetic activity (ISA) on sympathovagal balance and baroreflex sensitivity.

Beta blockers increase heart rate variability (HRV) and improve survival in coronary artery disease (CAD). The benefit of beta blockers with intrinsic sympathomimetic activity (ISA) in CAD still remains a matter of debate, and their effect on HRV has not yet been investigated. Therefore, we measured HRV, systolic blood pressure variability (BPV) and baroreflex sensitivity (BRS) under propranolol (PROP, without ISA, 160 mg q.d.), pindolol (PIN, with potent ISA, 15 mg q.d.) and placebo (PLA, q.d.) in 30 healthy subjects, aged 21-39 years, during controlled frequency breathing (0.30 Hz) in supine and tilt positions. PROP increased HRV in the high-frequency (0.15-0.40 Hz) band (PROP 7.4 +/- 1.0; PLA 6.9 +/- 1.4; PIN 6.8 +/- 1.0 ln MI2; P = 0.003), decreased BPV in the low-frequency band (at 0.1 Hz, Mayer waves) (PROP 0.6 +/- 0.7; PLA 1.3 +/- 1.1; PIN 1.2 +/- 1.2 ln mmHg2; P = 0.001) and enhanced BRS (PROP 14.6 +/- 9.5; PLA 8.0 +/- 6.8; PIN 8.7 +/- 6.8 ms mmHg-1; P = 0.001) in the supine position. After passive tilt, PROP decreased HRV in the low-frequency band (PROP 6.1 +/- 0.9; PLA 6.5 +/- 1.1; PIN 6.9 +/- 0.7 ln MI2; P < 0.001) and decreased Mayer waves (PROP 1.8 +/- 0.8; PLA 2.4 +/- 1.0; PIN 2.7 +/- 0.8 ln mm Hg2; P < 0.001). PIN increased the low-frequency HRV response, which is induced by passive tilt (PIN + 0.9 +/- 1.0; PLA + 0.3 +/- 1.3, PROP + 0.3 +/- 1.0 ln MI2; P = 0.026). Our results prove that beta-adrenergic blockade with potent ISA does not increase HRV, has no beneficial effect on autonomic balance and even exaggerates sympathetic responses to passive tilt.

Effects of mechanical unloading/loading on respiratory loop gain and periodic breathing in man.

We investigated the effect of mechanical unloading and loading on Cheyne-Stokes respiration (CSR) in seven intubated patients with preexisting CSR. For mechanical loading patients had to breathe against the resistance of the endotracheal tube. For mechanical unloading patients were supported with a volume-proportional pressure support in the proportional assist ventilation (PAV) mode whilst the flow-dependent (nonlinear) endotracheal tube resistance was continuously compensated for by means of the automatic tube compensation (ATC) mode. Mechanical unloading aggravated CSR as revealed by a prolongation of apnea time and by an increase in the so-called strength index whereas mechanical loading shortened apnea time and decreased strength index. To test whether the observed changes are caused by the effect of mechanical unloading/loading on respiratory loop gain (relationship between minute ventilation and arterial CO2 tension), the response of respiratory loop gain on mechanical unloading/loading was determined in five healthy subjects (without CSR). In each subject, mechanical unloading increased respiratory loop gain whereas mechanical loading decreased it.

Detection of endotracheal tube obstruction by analysis of the expiratory flow signal.

OBJECTIVE: Acute obstruction of endotracheal tubes (ETT) increases airway pressure, decreases tidal volume, increases the risk of dynamic hyperinflation by prolonging the duration of passive expiration, and prevents reliable calculation of tracheal pressure. We propose a computer-assisted method for detecting ETT obstruction during controlled mechanical ventilation. The method only requires measurement of the expiratory flow. DESIGN: Computer simulation; prospective study in two cases; retrospective study in one case and in seven patients with the adult respiratory distress syndrome (ARDS). SETTING: Laboratory of the Section of Experimental Anaesthesiology (University of Freiburg); surgical adult intensive care units in a university hospital (University of Basel) and in a university affiliated hospital (Zentralklinikum Augsburg). PATIENTS: 3 patients with partial ETT or bronchial obstructions and 7 ARDS patients. MEASUREMENTS AND RESULTS: Expiratory flow was measured using a pneumotachograph and integrated to obtain expiratory volume. The time-constant of passive expiration (tauE) as a function of expired volume [tauE(V(E)) function] was calculated from the expiratory volume/flow curve. We investigated the tauE(V(E)) function of data obtained from: (1) computer simulation of mechanically ventilated homogeneous and inhomogeneous lungs intubated with ETTs of different sizes; (2) one patient with an artificial ETT obstruction of 7.5 and 25% of the cross-sectional area of the ETT (case 1); (3) one patient with ETT obstruction due to secretions (case 2); (4) one patient with acute bronchial constriction (case 3); (5) seven ARDS patients who showed an increase in airway resistance of more than 2 cm H2O x s/l. It was found that an ETT obstruction caused an increase in tauE in early expiration (at high flow), whereas tauE in late expiration was virtually unchanged. The reason for this is the flow dependency of the increase in ETT resistance produced by ETT obstruction. Unlike ETT obstruction, an increase in pure airway resistance produced an increase in tauE throughout expiration. CONCLUSIONS: An ETT obstruction can be reliably distinguished from an increase in pure airway resistance by a characteristic pattern change in the tauE(V(E)) function, which can be detected easily even by an automated pattern recognition system.

Breathing pattern and additional work of breathing in spontaneously breathing patients with different ventilatory demands during inspiratory pressure support and automatic tube compensation.

OBJECTIVE: We designed a new ventilatory mode to support spontaneously breathing, intubated patients and to improve weaning from mechanical ventilation. This mode, named Automatic Tube Compensation (ATC), compensates for the flow-dependent pressure drop across the endotracheal tube (ETT) and controls tracheal pressure to a constant value. In this study, we compared ATC with conventional patient-triggered inspiratory pressure support (IPS). DESIGN: A prospective, interventional study. SETTING: A medical intensive care unit (ICU) and an ICU for heart and thoracic surgery in a university hospital. PATIENTS: We investigated two groups of intubated, spontaneously breathing patients: ten postoperative patients without lung injury, who had a normal minute ventilation (VE) of 7.6 +/- 1.7 l/min, and six critically ill patients who showed increased ventilatory demand (VE = 16.8 +/- 3.0 l/ min). INTERVENTIONS: We measured the breathing pattern [VE, tidal volume (VT), and respiratory rate (RR)] and additional work of breathing (WOBadd) due to ETT resistance and demand valve resistance. Measurements were performed under IPS of 5, 10, and 15 mbar and under ATC. RESULTS: The response of VT, RR, and WOBadd to different ventilatory modes was different in both patient groups, whereas VE remained unchanged. In postoperative patients, ATC, IPS of 10 mbar, and IPS of 15 mbar were sufficient to compensate for WOBadd. In contrast, WOBadd under IPS was greatly increased in patients with increased ventilatory demand, and only ATC was able to compensate for WOBadd. CONCLUSIONS: The breathing pattern response to IPS and ATC is different in patients with differing ventilatory demand. ATC, in contrast to IPS, is a suitable mode to compensate for WOBadd in patients with increased ventilatory demand. When WOBadd was avoided using ATC, the patients did not need additional pressure support.