Implementation of Enhanced Recovery After Surgery protocols for gastrostomy tube insertion in patients younger than 14 years of age: a retrospective cohort study.

BACKGROUND: Enhanced recovery after surgery (ERAS) protocols have improved treatment outcomes and have standardized patient care. OBJECTIVES: Identify the benefit of introducing the ERAS protocol for feeding after gastrostomy insertion with or without Nissen fundoplication, the effects on the time of reaching the full feeds the length of stay single-center experience, and complications associated with early feeding protocols. DESIGN: Retrospective cohort study SETTING: Tertiary hospital METHODS: The study review included cases performed between 2015 and 2021 by four surgeons, and cases performed in 2022 by all surgeons using ERAS feeding protocol (P) in a tertiary hospital. MAIN OUTCOME MEASURES: Comparison the mean and mode of the length of stay (LOS) and the time until the patient reached full feed (TFF). SAMPLE SIZE: 224 patients; 181 by the four surgeons and 43 cases by the ERAS protocol group. RESULTS: The difference in the ERAS protocol from the four surgeons in TFF and LOS was statistically significant (P<.001). There was no noticeable difference in postoperative complications after introducing the ERAS protocol. CONCLUSION: ERAS improved the TFF and decreased the LOS without any increase in procedure complications. Increasing bed utilization and reducing costs were two benefits of reducing LOS at our hospital. LIMITATIONS: Single-center study, which may not be generalizable. Multiple comorbidities. Travel time from different parts of the country could impact LOS. Retrospective and thus dependent on the accuracy of the information in file notes. CONFLICT OF INTEREST: None.

Incidence, predictors and outcomes of redo pancreatectomy in infants with congenital hyperinsulinism: a 16-year tertiary center experience.

PURPOSE: Recurrent severe hypoglycemic attacks often persist even after performing pancreatectomy for medically unresponsive congenital hyperinsulinism (CHI). In this study, we present our experience with redo pancreatectomy for CHI. METHODS: We reviewed all children who underwent pancreatectomy for CHI between January 2005 and April 2021 in our center. A comparison was made between patients whose hypoglycemia was controlled after primary pancreatectomy and patients who required reoperation. RESULTS: A total of 58 patients underwent pancreatectomy for CHI. Refractory hypoglycemia after pancreatectomy occurred in 10 patients (17%), who subsequently underwent redo pancreatectomy. All patients who required redo pancreatectomy had positive family history of CHI (p = 0.0031). Median extent of initial pancreatectomy was lesser in the redo group with borderline level of statistical significance (95% vs. 98%, p = 0.0561). Aggressive pancreatectomy at the initial surgery significantly (p = 0.0279) decreased the risk for the need to redo pancreatectomy; OR 0.793 (95% CI 0.645-0.975). Incidence of diabetes was significantly higher in the redo group (40% vs. 9%, p = 0.033). CONCLUSION: Pancreatectomy with 98% extent of resection for diffuse CHI, especially with positive family history of CHI, is warranted to decrease the chance of reoperation for persistent severe hypoglycemia.

Esophageal Perforation into the Pericardium in a 3-Year-Old Child with Esophageal Stricture: A Rare Complication Following Esophageal Dilatation.

Perforation of the esophagus during dilatation is a rare complication that might cause mortality. We present the report of a 3-year-old girl who was diagnosed with B cell acute lymphoblastic leukemia at 17 months of age. She experienced a complicated clinical course after chemotherapy was initiated, which included mucositis and acute pericarditis. She later developed an acquired esophageal stricture and tracheoesophageal fistula, which were managed with resection and primary anastomosis when she was in remission. Postoperatively, the patient developed a leak, which was treated conservatively. She subsequently developed a stricture that was treated successfully. On the fourth dilatation attempt and after she was sent home, she presented with persistent vomiting and low-grade fever and became vitally unstable on the same day, after stabilization, upper gastroenterology contrast revealed contrast filling the pericardium. She was managed conservatively with close observation and serial echocardiograms and then discharged home on day 18 in good condition after complete resolution of the pericardial effusion.

Experience of treating pediatric hepatoblastoma at King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia - Timely surgical intervention playing a key role.

BACKGROUND: Many studies have demonstrated that outcome in patients with hepatoblastoma is determined by tumor resectability and the presence or absence of metastatic disease. PURPOSE: To evaluate and disseminate information on diagnosis, treatment, and outcome of hepatoblastoma patients at a tertiary care hospital in Saudi Arabia. PATIENTS AND METHODS: Twenty-four pediatric patients with hepatoblastoma were treated at our institution between January 2005 and December 2012. The majority of our patients were stage III and above, while one-third of them presented with metastatic disease. Four (16.7%) had vascular invasion. Two-thirds of our patients (n = 16, 66.7%) had alpha-fetoprotein (AFP) level above 100,000 ng/mL. Twenty-one patients underwent surgery; two had upfront surgery before getting any chemotherapy, and 15 had surgery on schedule after pre-operative chemotherapy. Four patients had delayed surgery as the tumor was not resectable and received extra cycles of chemotherapy. Chemotherapy regimens used were based on SIOPEL study protocols until 2011 and Children's Oncology Group (COG) protocol from 2012 onwards. Relapse, progressive disease, or death from any cause were defined as events. RESULTS: Five-year overall survival (OS) of the cohort over a median follow-up time of 56.1 months was 70.6% ± 9.4% with seven (29.2%) events of mortality. No significant difference was found for age at diagnosis (less than 2 years vs. more), stage of disease, AFP levels (less than 100,000 vs. more), vascular invasion, or presence of metastatic disease at presentation in terms of OS. However, children receiving upfront or scheduled as-per-protocol surgery fared better than those who had delayed surgery (as the tumor was not resectable and they received extra cycles of chemotherapy) or did not undergo any surgery (P-Value .001). CONCLUSION: Favorable survival outcome could be achieved with complete tumor excision and adjuvant chemotherapy. Inability to perform surgical excision was the single most important predictor of mortality in our patients.

Management of Aspergillus pleural empyema with combined systemic and intrapleural antifungal therapy in a pediatric patient: Case report.

We present the case of an 8-year-old immunocompromised boy with invasive pulmonary aspergillosis, complicated with pleural empyema and disseminated to the bone and central nervous system (CNS). The patient was treated with combined systemic antifungal agents (voriconazole and caspofungin) and intrapleural instillation of liposomal amphotericin B, in addition to surgical intervention. The treatment was well tolerated and resulted in remarkable clinical and radiological pulmonary improvement.

Intramural esophageal foreign body in a child.

Foreign body ingestion is a common problem in the pediatric population. The majority of cases occur between 6 months and 3 years of age. Major complications, including bowel perforation and obstruction, have been reported. Forty percent of ingested foreign bodies are unwitnessed, and in fact, many are asymptomatic. We report the case of a 2-year-old girl who was referred to King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia (KFSH&RC) with suspected congenital esophageal stenosis. Upon investigation, she was diagnosed with intramural esophageal foreign body.

Duodenotubular Flap-New Biliary Reconstructive Procedure.

BACKGROUND: Although Roux-en-Y hepaticojejunostomy is considered the gold standard of biliary reconstruction after excision of a choledochal cyst, there is increasing popularity of hepaticoduodenostomy, as it is easier to perform laparoscopically and provides physiologic bile drainage into the duodenum. Our animal research study had the goal to develop and test a new biliary reconstructive procedure (the duodenotubular flap [DTF]), with the advantages of providing physiological bile flow into the duodenum, technical simplicity of duodenal conduit construction, and ability of endoscopic assessment in case of complications. MATERIALS AND METHODS: The DTF procedure consists of transection of the common bile duct (CBD), construction of the DTF from the second part of the duodenum, and biliary-enteric anastomosis. The first group of 6 dogs underwent reconstruction as a single surgical procedure. The second group of 4 dogs underwent the DTF procedure after the preparatory step of laparoscopic clipping of the CBD (for 7 days), to simulate the pathology of the choledochal cyst (extrahepatic biliary obstruction) and to ease the anastomosis. Laboratory analyses were performed pre- and postoperatively. RESULTS: From the first group, 3 dogs developed a postoperative leak at the biliary-enteric anatomosis. The leak was recognized on postoperative day 4 in 2 dogs. They underwent an emergency abdominal exploration with redo anastomosis and had a complete recovery. The third dog died suddenly on postoperative day 10. Autopsy revealed incomplete disruption of the biliary-enteric anastomosis. In the second group, 3 dogs had an uneventful recovery, but 1 died on postoperative day 3. Autopsy revealed intraperitoneal bleeding with intact anastomotic and staple sites. None of the dogs in either group experienced leak at the staple lines, and none of the 8 surviving dogs developed postoperative cholangitis during the follow-up period from 15 to 20 months. CONCLUSIONS: The DTF procedure is feasible, simple, and quick, simulating physiological anatomy. Regarding the safety, a wide anastomosis seems to be the core of success.

Prune belly syndrome with overlapping presentation of partial urorectal septum malformation sequence in a female newborn with absent perineal openings.

Prune belly syndrome (PBS) is a rare congenital anomaly characterized in males by a triad of anomalous genitourinary tract, deficient development of abdominal wall muscles, and bilateral cryptorchidism. Although similar anomalies have been reported in females, by definition they do not full fill the classical triad. Urorectal septum malformation sequence (URSM) is a lethal condition characterized by presence of ambiguous genitalia, absent perineal openings (urogenital and anal), and lumbosacral abnormalities. In this original case report, the authors discuss the presentation and management of what would be analogous to a Woodhouse category 1 PBS in a female newborn associated with an overlapping presentation of URSM.

Gastric adenocarcinoma presenting with gastric outlet obstruction in a child.

Gastric carcinoma is extremely rare in children representing only 0.05% of all gastrointestinal malignancies. Here, we report the first pediatric case of gastric cancer presenting with gastric outlet obstruction. Upper endoscopy revealed a markedly thickened antral mucosa occluding the pylorus and a clean base ulcer 1.5 cm × 2 cm at the lesser curvature of the stomach. The narrowed antrum and pylorus underwent balloon dilation, and biopsy from the antrum showed evidence of Helicobacter pylori gastritis. The biopsy taken from the edge of the gastric ulcer demonstrated signet-ring-cell type infiltrate consistent with gastric adenocarcinoma. At laparotomy, there were metastases to the liver, head of pancreas, and mesenteric lymph nodes. Therefore, the gastric carcinoma was deemed unresectable. The patient died few months after initiation of chemotherapy due to advanced malignancy. In conclusion, this case report underscores the possibility of gastric adenocarcinoma occurring in children and presenting with gastric outlet obstruction.

Intra-abdominal insertion of sewing needles: a rare method of child abuse.

The insertion of sewing needles into the abdominal cavity is an uncommon form of child abuse. We report a 2-and-a-half-year-old boy with 2 intra-abdominal sewing needles that were discovered during the evaluation of chronic abdominal pain and vomiting. This case report illustrates the wide range with which abusive injury can present in children. Pediatricians need to be alerted to this newly-recognized and the increasing form of child abuse so that they examine and diagnose their patients appropriately.

Laparoscopic pancreatectomy for persistent hyperinsulinemic hypoglycemia of infancy.

BACKGROUND: Persistent hyperinsulinemic hypoglycemia of infancy (PHHI) is considered the most common cause of persistent neonatal hypoglycemia. Management of PHHI involves use of medical agents and its failure is an indication of surgical intervention. Traditionally, an open pancreatectomy was the standard of care but recently laparoscopic pancreatectomy was described. We report our experience with laparoscopic pancreatectomy for PHHI for the period from March 2004 to February 2008. METHODS: A retrospective chart review was conducted for patients managed for PHHI with laparoscopic pancreatectomy for that period. Demographic and clinical data were retrieved. Descriptive data were generated, and SPSS version 10 statistical package (SPSS, Chicago, Ill) was used. RESULTS: Twelve patients diagnosed with PHHI were managed with laparoscopic pancreatectomy for that period. Median age at procedure was 11.5 months (range, 0.5-89 months). Median extent of pancreatectomy was 90% (range, 85%-95%). There were 2 (16%) conversions to open technique. One patient (8%) required reoperation 3 months after the procedure. Patients were followed up for a median of 23.5 months (range, 3-48 months). Four (33%) were euglycemic with no medications. Three patients remained on octreotide postoperatively to be euglycemic, and 3 patients needed a combination of octreotide and diazoxide. One patient remained euglycemic for 10 months then started on octreotide because of recurrence of hypoglycemia. One patient remained hypoglycemic postoperatively and required reoperation 3 months later to control symptoms. He became diabetic 4 months after reoperation on insulin. CONCLUSIONS: Our data suggest that laparoscopic pancreatectomy for medically unresponsive PHHI is feasible and safe. Longer follow-up is needed to ascertain effectiveness.

Laparoscopic duodenoduodenostomy in a newborn with situs inversus totalis.

Situs viscerum inversus is a rare embryologic anomaly with a mirror-image transposition of the normal anatomy of organs. The coexistence with the duodenal atresia is extremely rare. This report describes a newborn with duodenal atresia and situs inversus totalis who was managed laparoscopically. According to our knowledge, this is the first report of this type of associated anomaly to be successfully managed by the laparoscopic approach.

Feasibility and safety of laparoscopic adrenalectomy in children: special emphasis on neoplastic lesions.

BACKGROUND: Laparoscopic adrenalectomy (LA) in children became a viable option for the resection of adrenal lesions. Few reports have been published in the last few years documenting its safety and feasibility. In this paper, we report our experience with LA over the last 10 years, with special emphasis on malignant lesions. METHODS: A retrospective chart review was undertaken for patients managed with LA from 1997 to 2006 at King Faisal Specialist Hospital and Research Center. Demographic and clinical data were retrieved and descriptive data were generated. RESULTS: Twenty-nine patients were managed with LA at our institution over that period. There were 16 females and 13 males with a median age of 3 years. Adrenal lesions were left sided in 15, right sided in 11, and bilateral in 3 patients. Twenty-one patients had malignant lesions, while 8 had benign lesions. Lesions ranged in size from 2.8 to 7 cm in diameter. There were 3 conversions (10%) to the open technique. Resection margins were positive for tumor in 5 cases (17%), and all had stage IV neuroblastoma. Follow-up range was from 9 months to 9.5 years (9 months to 6.3 years for malignant lesions). There were no major postoperative complications and no port-site metastasis. Three patients had local recurrence, 2 of them had free resection margins. One patient managed for bilateral neuroblastoma has stable residual disease 17 months after resection. Hospital stay ranged from 2 to 4 days. At the time of this report, 3 patients with neuroblastoma had died with progressive metastatic refractory disease. CONCLUSIONS: Our data have shown the feasibility, safety, and effectiveness of LA for adrenal lesions, including malignant tumors. The relatively long follow-up data regarding the malignant lesions attest to its role in the management of such lesions. Appropriate selection criteria and appropriate laparoscopic surgical expertise are required to ensure its success.

Pediatric short bowel syndrome: adaptation after massive small bowel resection.

BACKGROUND: Short bowel syndrome (SBS) develops after massive small bowel resections. Patients with less than 12 cm of jejunoileum have a slim possibility of being weaned from parenteral nutrition (PN). PATIENTS AND METHODS: In a retrospective review of records of consecutive patients with SBS, 8 patients were evaluated for treatment by adaptation and weaning from PN. These included 4 patients with class I SBS (0-10 cm of small bowel), one with class II SBS (>10-25 cm), one with class III SBS (>25-50 cm), and 2 with class IV SBS (>50-75 cm). Adaptation was assessed by measuring growth in the small bowel and the ability to be weaned from PN. RESULTS: Adaptation was achieved primarily by extending the length of jejunoileum by approximately 450% over the first 2.5 years after resection and by increasing the degree of colonic fermentation and absorption of nutrients. As of July 1, 2005, all of the patients were off PN, with the exception of 2 patients with class I-A SBS: patient 3 had a remaining jejunoileum of only 2.5 cm and patient 4 had a remaining jejunoileum of 9 cm but developed eosinophilic enterocolitis. These 2 patients continued with PN on alternate months. CONCLUSIONS: Bowel growth after massive small bowel resection provides an objective parameter of adaptation and a means of predicting ability to be weaned from PN. Aggressive nutritional support makes even patients with class I SBS, whose disease was previously considered hopeless, likely candidates to achieve freedom from PN.