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1.
J Vet Intern Med ; 34(3): 1091-1101, 2020 May.
Artículo en Inglés | MEDLINE | ID: mdl-32364632

RESUMEN

BACKGROUND: Left-sided congestive heart failure (CHF) is characterized by increased filling pressures and related Doppler echocardiographic (DE) filling patterns. HYPOTHESIS: Doppler echocardiographic variables of left ventricular filling derived from transmitral flow, pulmonary vein flow, and tissue Doppler can be used to detect CHF in cats with hypertrophic cardiomyopathy (HCM). ANIMALS: Forty-seven client-owned cats. METHODS: Prospective clinical cohort study. Cats underwent physical examination, thoracic radiography, analysis of N-terminal pro-brain natriuretic peptide (NT-proBNP), and transthoracic echocardiography and were divided into 3 age-matched groups: Group 1 (apparently healthy control), Group 2 (preclinical HCM), and Group 3 (HCM and CHF). Measured and calculated variables included respiratory rate, DE estimates, serum NT-proBNP concentration, and radiographic CHF score. Groups were compared using ANOVA, and receiver operating characteristic (ROC) curve and multivariate analyses were used to identify diagnostic cutoffs for the detection of CHF. RESULTS: Fifteen cats were in Group 1, 17 in Group 2, and 15 in Group 3. The ROC analysis indicated that the ratio of peak velocity of early diastolic transmitral flow to peak velocity of late diastolic transmitral flow (area under the curve [AUC], 1.0; diagnostic cutoff, 1.77; P = .001), ratio of left atrial size to aortic annular dimension (AUC, 0.91; diagnostic cutoff, 1.96; P = .003), left atrial diameter (AUC, 0.89; cutoff, 18.5 mm; P = .004), diastolic functional class (AUC, 0.89; cutoff, class 2; P = .005), respiratory (AUC, 0.79; cutoff, 36 breaths per minute [brpm]; P = .02), and the ratio of the peak velocity of fused early and late transmitral flow velocities to the peak velocity of the fused early and late diastolic tissue Doppler waveforms (AUC, 0.74; cutoff, 15.1; P = .05) performed best for detecting CHF. CONCLUSIONS AND CLINICAL IMPORTANCE: Various DE variables can be used to detect CHF in cats with HCM. Determination of the clinical benefit of such variables in initiating treatments and assessing treatment success needs further study.


Asunto(s)
Cardiomiopatía Hipertrófica/veterinaria , Enfermedades de los Gatos/diagnóstico por imagen , Ecocardiografía Doppler/veterinaria , Insuficiencia Cardíaca/veterinaria , Animales , Cardiomiopatía Hipertrófica/diagnóstico por imagen , Gatos , Estudios de Cohortes , Ecocardiografía Doppler/métodos , Femenino , Insuficiencia Cardíaca/diagnóstico por imagen , Masculino , Péptido Natriurético Encefálico/sangre , Fragmentos de Péptidos/sangre , Estudios Prospectivos , Frecuencia Respiratoria
2.
Vet Radiol Ultrasound ; 58(4): 411-421, 2017 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-28402031

RESUMEN

Osseous-associated cervical spondylomyelopathy in dogs is characterized by both static and dynamic spinal cord compression; however, standard MRI methods only assess static compression. In humans with cervical spondylotic myelopathy, kinematic MRI is commonly used to diagnose dynamic spinal cord compressions. The purpose of this prospective, analytical study was to evaluate kinematic MRI as a method for characterizing the dynamic component of osseous-associated cervical spondylomyelopathy in dogs. We hypothesized that kinematic MRI would allow visualization of spinal cord compressions that were not identified with standard imaging. Twelve client-owned dogs with osseous-associated cervical spondylomyelopathy were enrolled. After standard MRI confirmed a diagnosis of osseous-associated cervical spondylomyelopathy, a positioning device was used to perform additional MRI sequences with the cervical vertebral column flexed and extended. Morphologic and morphometric (spinal cord height, intervertebral disc width, spinal cord width, vertebral canal height, and spinal cord area) assessments were recorded for images acquired with neutral, flexion, and extension imaging. A total of 25 compressions were seen with neutral positioning, while extension identified 32 compressions. There was a significant association between extension positioning and presence of a compressive lesion at C4-C5 (p = 0.02). Extension was also associated with a change in the most severe site of compression in four out of 12 (33%) dogs. None of the patients deteriorated neurologically after kinematic imaging. We concluded that kinematic MRI is a feasible method for evaluating dogs with osseous-associated cervical spondylomyelopathy, and can reveal new compressions not seen with neutral positioning.


Asunto(s)
Vértebras Cervicales/diagnóstico por imagen , Enfermedades de los Perros/diagnóstico por imagen , Compresión de la Médula Espinal/veterinaria , Animales , Vértebras Cervicales/patología , Enfermedades de los Perros/patología , Perros , Femenino , Imagen por Resonancia Magnética/veterinaria , Masculino , Posicionamiento del Paciente/veterinaria , Estudios Prospectivos , Compresión de la Médula Espinal/diagnóstico por imagen , Compresión de la Médula Espinal/patología
3.
Am J Vet Res ; 78(4): 458-464, 2017 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-28346006

RESUMEN

OBJECTIVE To characterize and compare MRI susceptibility artifacts related to titanium and stainless steel monocortical screws in the cervical vertebrae and spinal cord of canine cadavers. SAMPLE 12 canine cadavers. PROCEDURES Cervical vertebrae (C4 and C5) were surgically stabilized with titanium or stainless steel monocortical screws and polymethylmethacrylate. Routine T1-weighted, T2-weighted, and short tau inversion recovery sequences were performed at 3.0 T. Magnetic susceptibility artifacts in 20 regions of interest (ROIs) across 4 contiguous vertebrae (C3 through C6) were scored by use of an established scoring system. RESULTS Artifact scores for stainless steel screws were significantly greater than scores for titanium screws at 18 of 20 ROIs. Artifact scores for titanium screws were significantly higher for spinal cord ROIs within the implanted vertebrae. Artifact scores for stainless steel screws at C3 were significantly less than at the other 3 cervical vertebrae. CONCLUSIONS AND CLINICAL RELEVANCE Evaluation of routine MRI sequences obtained at 3.0 T revealed that susceptibility artifacts related to titanium monocortical screws were considered mild and should not hinder the overall clinical assessment of the cervical vertebrae and spinal cord. However, mild focal artifacts may obscure small portions of the spinal cord or intervertebral discs immediately adjacent to titanium screws. Severe artifacts related to stainless steel screws were more likely to result in routine MRI sequences being nondiagnostic; however, artifacts may be mitigated by implant positioning.


Asunto(s)
Tornillos Óseos/veterinaria , Vértebras Cervicales/diagnóstico por imagen , Perros , Imagen por Resonancia Magnética/veterinaria , Polimetil Metacrilato , Médula Espinal/diagnóstico por imagen , Animales , Artefactos , Cadáver , Vértebras Cervicales/patología , Imagen por Resonancia Magnética/métodos , Acero Inoxidable , Titanio
4.
J Am Anim Hosp Assoc ; 51(6): 392-5, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-26535458

RESUMEN

A 3 yr old, spayed, female miniature mchnauzer was presented for rhythmic, spontaneous contractions of the abdominal wall and across the costal arches. The rate of contractions coincided with the heart rate and increased during exercise. The dog was diagnosed with primary hypoparathyroidism based on low plasma ionized calcium and serum parathyroid hormone (PTH) concentrations. Fluoroscopic exam confirmed the diagnosis of a synchronous diaphragmatic flutter. Treatment of the hypocalcemia led to resolution of the diaphragmatic flutter.


Asunto(s)
Diafragma/fisiopatología , Enfermedades de los Perros/etiología , Hipo/veterinaria , Hipoparatiroidismo/veterinaria , Animales , Antiácidos/uso terapéutico , Calcitriol/uso terapéutico , Carbonato de Calcio/uso terapéutico , Agonistas de los Canales de Calcio/uso terapéutico , Perros , Femenino , Hipo/etiología , Hipocalcemia/complicaciones , Hipocalcemia/veterinaria , Hipoparatiroidismo/complicaciones , Hipoparatiroidismo/diagnóstico , Hipoparatiroidismo/tratamiento farmacológico , Nervio Frénico
5.
Vet Radiol Ultrasound ; 52(2): 173-8, 2011.
Artículo en Inglés | MEDLINE | ID: mdl-21388469

RESUMEN

We report a canine computed tomography (CT) pulmonary angiography technique using multidetector CT (MDCT). CT pulmonary angiography using a 16 slice MDCT was performed on five healthy, anesthetized beagles. A helical acquisition with pitch of 1.4 was used. The time delay for the angiographic study was determined using a bolus-tracking program. A dose of 400 mg I/kg of nonionic contrast medium (Iohexol 300 mg I/ml) was administered to each dog via a cephalic catheter using an angiographic power injector at a rate of 5 ml/s. In two dogs a second study, using a contrast medium dose of 200 and 600 mg I/kg was performed. Arterial enhancement of transverse and reformatted images was classified subjectively as excellent, good, or poor, and assessed objectively by measuring Hounsfield units at the right main pulmonary artery. Angiographic studies were evaluated by two radiologists to determine the number of subsegmental arterial branches visualized. The median number of subsegmental arterial branches identified was five (range: 2-7). Based on the time attenuation curve obtained by the bolus-tracking program, there was consistent enhancement of the right main pulmonary artery beginning at 6 s and peaking at 8 s in 4/5 dogs. The contrast medium dose of 400 mg I/kg produced good to excellent vascular enhancement in the same 4/5 dogs. A dose of 200 mg I/kg resulted in poor enhancement. CT pulmonary angiography using MDCT and an automated bolus-tracking program allows rapid, consistent evaluation of the pulmonary vasculature using a single dose of 400 mg I/kg of contrast medium.


Asunto(s)
Angiografía/veterinaria , Perros , Pulmón/irrigación sanguínea , Pulmón/diagnóstico por imagen , Tomografía Computarizada por Rayos X/veterinaria , Angiografía/métodos , Animales , Medios de Contraste/administración & dosificación , Arteria Pulmonar/diagnóstico por imagen , Valores de Referencia , Tomografía Computarizada por Rayos X/instrumentación
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