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Introduction: Hydatidosis, caused by the Echinococcus tapeworm, typically manifests with hepatic and pulmonary symptoms, but cardiac involvement, especially in pediatric cases, poses a rare challenge. This overview emphasizes the diagnostic complexities and potential complications associated with this uncommon parasitic disease. Case presentation: A 4-year-old child was presented with epigastric pain after an abdominal impact trauma. Clinical examination revealed tachycardia, fever, and pericardial effusion with an intramyocardial cyst. Hydatid serology confirmed the diagnosis, and subsequent imaging ruled out additional localizations. Treatment involved albendazole, pericardial drainage, and cyst removal, resulting in a favorable outcome. Discussion: Cardiac hydatid cysts, comprising only 0.5--2% of visceral cases, often occur in underdeveloped regions. The authors' case, affecting the right ventricle in a pediatric patient, contributes to the understanding of varied presentations. Diagnosis relies on echocardiography, computed tomography scans, and MRI, with surgery being the mainstay treatment. Symptomatic cases demand prompt intervention due to potential complications. Conclusion: This case underscores the intricate diagnostic journey and management challenges posed by cardiac hydatid cysts, particularly in pediatric populations. Collaboration between medical disciplines is crucial for timely diagnosis and effective treatment, emphasizing the importance of ongoing research in endemic regions.
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BACKGROUND: Ankylosing spondylitis (AS) is a type of chronic inflammation that is most prevalent in young adults and is characterized by an inflammatory enthesiopathy that gradually develops toward ossification and ankylosis. If inflammation is left unchecked, it can potentially lead to complications such as secondary amyloidosis, also known as AA amyloidosis, involving the deposition of amyloid serum A protein. Our case presents with a thyroid localization of AA amyloidosis which is secondary to this AS. Such a case has been described in only four cases in the literature. Cardiac localization of AA amyloidosis has been exceptionally described in the literature. CASE PRESENTATION: We report the case of a young patient with severe AS complicated by secondary amyloidosis with thyroid, cardiac, and probably renal localization. He was treated with anti-TNF therapy, and his condition improved significantly. CONCLUSIONS: Our case presents several localizations of AA amyloidosis secondary to this AS. Although cardiac involvement is rare in secondary AA amyloidosis, it should always be screened for, even in a cardiacly asymptomatic patient.
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OBJECTIVE: Our case-control study aimed to access the potential association of insertion/deletion (I/D) ACE (angiotensin converting enzyme) gene polymorphism with myocardial infarction (MI) risk of occurrence among a sample of Moroccan patients, especially young ones. RESULTS: Distribution of I/D ACE gene variant among cases vs controls, showed that healthy controls carried out higher frequency of wild type allele I compared to cases (23.5% vs 21.79% respectively), when cases were carrying higher frequency of mutant allele D (78.21% vs 76.5% for controls). Patients were-after this- divided into two groups of < 45 and > 55 years of age, to investigate whether or not younger patients carried out higher frequency of the mutant allele D, than older ones. As expected, < 45 years old patients carried out more DD genotype than older ones (68.9% vs 54.6% respectively), and higher frequency of mutant allele D (81.08% vs 75% respectively). Besides, a tendency to a positive association was found under the recessive genetic transmission model (OR [95% CI] = 1.85 [0.93-3.69], P = 0.08), suggesting that the I/D ACE polymorphism may be associated with MI occurrence among younger patients (< 45 years of age).