Radiotherapy of bone metastases.

We present the update of the recommendations of the French society of oncological radiotherapy on bone metastases. This is a common treatment in the management of patients with cancer. It is a relatively simple treatment with proven efficacy in reducing pain or managing spinal cord compression. More complex treatments by stereotaxis can be proposed for oligometastatic patients or in case of reirradiation. In this context, increased vigilance should be given to the risks to the spinal cord.

[Stereotactic body radiation therapy for spine bone oligometastatic disease]. / Radiothérapie stéréotaxiques des métastases osseuses des lésions vertébrales.

Stereotactic radiotherapy is an ever more common technique, regardless of the location treated. However, spinal stereotactic radiotherapy requires a particular technicality in order to ensure its proper realization. There is now a large literature defining the type of imaging to be used, the dose to be delivered and the delineation of target volumes. This technique can achieve a significant local control and an interesting analgesic efficiency. However, its place in relation to conventional radiotherapy remains limited because it requires MRI imaging and a significantly longer patient management during the treatment fraction. In this context, it is currently mainly restricted to oligometastatic patients or for re-irradiations.

[Inter- and intrafraction imaging during stereotactic body radiation therapy: Which solutions for which tumours?] / Imagerie inter- et intrafractions en radiothérapie stéréotaxique extracrânienne : quelles solutions pour quelles tumeurs ?

Due to high dose gradients, stereotactic body radiation therapy requires high precision in the location of the tumour. Uncertainties in the positioning can introduce serious damage on organs at risk and consequently can reduce tumour local control. A better tumour location can be achieved by controlling its position with an efficient inter and intrafraction imaging procedure. The various imaging techniques available on treatment systems are presented and performances are discussed. Finally, propositions are given in terms of imaging system according to the location treated by stereotactic body radiation therapy.

[Image-guided radiotherapy in lung cancer]. / Radiothérapie guidée par l'image dans le cancer du poumon.

Image-guided radiotherapy takes place at every step of the treatment in lung cancer, from treatment planning, with fusion imaging, to daily in-room repositioning. Managing tumoral and surrounding thoracic structures motion has been allowed since the routine use of 4D computed tomography (4DCT). The integration of respiratory motion has been made with "passive" techniques based on reconstruction images from 4DCT planning, or "active" techniques adapted to the patient's breathing. Daily repositioning is based on regular images, weekly or daily, low (kV) or high (MV) energy. MRI and functional imaging also play an important part in lung cancer radiation and open the way for adaptative radiotherapy.

[Popliteal venous thrombosis associated with a false aneurysm revealing femoral exostosis in a child]. / Thrombose veineuse profonde et faux anévrisme poplité révélant une exostose fémorale chez une enfant.

Recent unprovoked and symptomatic thrombosis of the left popliteal vein was diagnosed in a 9-year-old girl. Treatment with low-molecular-weight heparin was initiated in association with vitamin K antagonist (INR 2.5), and compressive stockings. Two and a half months later, the ultrasound examination revealed a false aneurysm of the left distal superficial femoral artery. Knee X-rays showed a distal femoral exostosis. MRI clarified the relationship between the false aneurysm and the exostosis. Bone scintigraphy eliminated multiple exostoses. Resection of the false aneurysm associated with end-to-end femoro-popliteal saphenous bypass and exostosectomy in the same operative time were performed. On histopathological examination there was no sign of malignant transformation. Vascular complications of exostoses are infrequent and the association with deep venous thrombosis and false aneurysm is exceptional. This case report illustrates the contribution of knee X-rays to unravel this unusual clinical presentation.

[Peripheral arterial disease with lower limb claudication: Medical treatment]. / Artériopathie oblitérante chronique au stade d'ischémie d'effort : traitement médical.

Whereas the complaint from a patient with intermittent arterial claudication is walking impairment, prognosis is linked to an increased risk of cardiovascular ischemic events due to the diffuse nature of the atherosclerosis. The objectives of the medical treatment therefore include improvement of walking limit, prevention of myocardial infarction, stroke and cardiovascular death, and preventive measures to avoid progression to critical lower limb ischemia. The key areas of treatment focus on smoking cessation, exercise rehabilitation, with supervised therapy if possible, cardiovascular risk prevention with antiplatelet drugs, statins and angiotensin converting enzymes, and correction of atherosclerotic risk factors with well-defined targets (LDL less than 1g/L, HDL greater than 0.4g/L, HbA(1c) less than 6.5%, brachial blood pressure less than 140/90 or 130/80mmHg in case of diabetes or renal insufficiency, body mass index less than 25kg/m(2)). Limitation or avoidance of progression to local critical ischemia requires control of atherosclerotic risk factors and proper foot care. The patient with arterial claudication needs to understand the local and general risks of arterial atherosclerotic disease, and to be involved in his/her own treatment. Obtaining patient compliance to medical care is fundamental: specific educational workshops are of great value for this.

[Cystic lymphangioma: an unusual cause of lower limb lymphedema]. / Malformation lymphatique kystique : cause rare d'un lymphoedème unilatéral des membres inférieurs.

We report an unusual cause of unilateral lymphedema of the right limb rapidly increasing in a young woman. Ultrasonography ruled out the diagnosis of iliac deep venous thrombosis or extrinsic compression: the B mode scan revealed a mass located below the aortic bifurcation and along the iliac vessels, without any compressive effect. The lesion was heterogeneous associating both tissular and cystic aspects. The lower limb lymphoscintigraphy showed an interruption of the colloid circulation at the right iliac level. Computed tomography did not give any additional information. Magnetic resonance imaging before then after gadolinium showed typical aspects of cystic lymphangioma and confirmed the ultrasonography hypothesis. Considering that this tumor is benign, that surgery would be difficult because of the anatomic situation of the mass, and that post-operative involution of the edema is uncertain, the treatment was based on compressive stockings and regular follow up.