RESUMEN
BACKGROUND AND PURPOSE: Twenty-four-hour ambulatory blood pressure and heart rate monitoring (24-h ABPM) can provide vital information on circadian blood pressure (BP) profiles, which are commonly abnormal in Parkinson's disease with and without autonomic failure (PD + AF and PD) and multiple system atrophy (MSA). Twenty-four-hour ABPM has not been directly compared between these disorders regarding cardiovascular autonomic function. Our aim was to determine the usefulness of 24-h ABPM with diary compared to head-up tilting (HUT) in diagnosing orthostatic hypotension (OH) in these patients. METHODS: Seventy-four patients (23 MSA, 18 PD + AF, 33 PD) underwent cardiovascular autonomic screening followed by 24-h ABPM with diary. Standing tests were included during 24-h ABPM. The sensitivity and specificity in detecting OH from the 24-h ABPM standing test were compared with HUT. RESULTS: There was no difference in OH during HUT between MSA and PD + AF (P > 0.05). There was a higher proportion of abnormal BP circadian rhythms in MSA and PD + AF compared to PD (P < 0.05) but not between MSA and PD + AF (P > 0.05). Patients were divided into groups with OH (OH+) and without OH (OH-) on HUT. Using the standing test during 24-h ABPM, a systolic BP fall of >20 mmHg showed a sensitivity and specificity of 82% and 100% (area under the curve 0.91, 95% confidence interval 0.84-0.98) in differentiating OH+ from OH-. CONCLUSIONS: Parkinson's disease with autonomic failure and MSA patients had similar circadian BP patterns suggesting that autonomic dysfunction influences abnormal BP circadian patterns similarly in these disorders. The higher sensitivity and specificity in detecting OH using a systolic BP fall of >20 mmHg compared to a diastolic BP fall of >10 mmHg during the standing test supports its usefulness to assess autonomic function in MSA and PD.
Asunto(s)
Presión Sanguínea/fisiología , Frecuencia Cardíaca/fisiología , Hipotensión Ortostática/diagnóstico , Atrofia de Múltiples Sistemas/fisiopatología , Enfermedad de Parkinson/fisiopatología , Anciano , Anciano de 80 o más Años , Sistema Nervioso Autónomo/fisiopatología , Monitoreo Ambulatorio de la Presión Arterial , Sistema Cardiovascular/fisiopatología , Ritmo Circadiano/fisiología , Femenino , Humanos , Hipotensión Ortostática/complicaciones , Hipotensión Ortostática/fisiopatología , Masculino , Persona de Mediana Edad , Atrofia de Múltiples Sistemas/complicaciones , Enfermedad de Parkinson/complicaciones , Postura/fisiología , Pruebas de Mesa InclinadaRESUMEN
STUDY DESIGN: In 2014, the adult spinal cord injury (SCI) common data element (CDE) recommendations were made available. This project was a review of the adult SCI CDE for relevance to children and youth with SCI. OBJECTIVES: The objective of this study was to review the National Institute of Neurologic Disorders and Stroke (NINDS) adult SCI CDEs for relevance to children and youth with SCI. SETTING: International. METHODS: The pediatric working group consisted of international members with varied fields of expertise related to pediatric SCI. The group convened biweekly meetings for 6 months in 2015. All of the adult SCI CDEs were reviewed, evaluated and modified/created for four age groups: 0-5 years, 6-12 years, 13-15 years and 16-18 years. Whenever possible, results of published research studies were used to guide recommendations. In the absence of empirical support, grey literature and international content expert consensus were garnered. Existing pediatric NINDS CDEs and new CDEs were developed in areas where adult recommendations were not appropriate. After internal working group review of domain recommendations, these pediatric CDEs were vetted during a public review from November through December 2015. RESULTS: Version 1.0 of the pediatric SCI CDEs was posted in February 2016. CONCLUSION: The pediatric SCI CDEs are incorporated directly into the NINDS SCI CDE sets and can be found at https://commondataelements.ninds.nih.gov.
Asunto(s)
Elementos de Datos Comunes , Traumatismos de la Médula Espinal , Adolescente , Niño , Preescolar , Humanos , Lactante , Recién Nacido , National Institute of Neurological Disorders and Stroke (U.S.) , Traumatismos de la Médula Espinal/diagnóstico , Traumatismos de la Médula Espinal/epidemiología , Traumatismos de la Médula Espinal/terapia , Estados UnidosRESUMEN
STUDY DESIGN: Cross-sectional survey. OBJECTIVES: To estimate the prevalence, predictors and impact of self-reported pain and spasticity and examine variables affecting quality of life in individuals with a traumatic spinal cord injury (SCI). SETTING: Nationwide, Denmark. METHODS: An anonymous questionnaire was sent out to individuals with a traumatic SCI. The questionnaire included questions about demographics and SCI characteristics, pain, spasticity and quality of life. RESULTS: In total, 537 questionnaires were completed. Seventy-three percent reported chronic pain of which 60% used descriptors suggestive of neuropathic pain. The average pain intensity and interference were 5.6 (s.d. 2.3) and 5.0 (s.d. 2.8), respectively, on a 0-10 numeric rating scale (NRS), and 28.1% reported severe pain. Seventy-one percent reported spasticity. Average interference of spasticity was 2.9 (s.d. 2.7). Quality of life scores were 6.5 (s.d. 2.5) for life and life situation, 5.5 (s.d. 2.6) for physical health and 6.7 (s.d. 2.6) for mental health on the NRS (0-10). Female gender was associated with lower mental health scores and tetraplegia with lower physical health scores, and high pain interference and shorter time since injury were associated with lower quality-of-life scores for all three parameters. Pain with descriptors suggestive of neuropathic pain was associated with lower quality-of-life scores than pain without such descriptors. CONCLUSION: Chronic pain and spasticity are common problems after SCI, and in particular, high pain interference is associated with lower quality of life.
Asunto(s)
Espasticidad Muscular/epidemiología , Neuralgia/epidemiología , Calidad de Vida/psicología , Traumatismos de la Médula Espinal , Adulto , Anciano , Estudios Transversales , Dinamarca/epidemiología , Femenino , Encuestas Epidemiológicas , Humanos , Masculino , Persona de Mediana Edad , Espasticidad Muscular/complicaciones , Neuralgia/complicaciones , Factores Sexuales , Traumatismos de la Médula Espinal/complicaciones , Traumatismos de la Médula Espinal/epidemiología , Traumatismos de la Médula Espinal/psicología , Encuestas y CuestionariosRESUMEN
STUDY DESIGN: Hospital-based incidence study. OBJECTIVES: To assess the incidence of traumatic spinal cord injuries (TSCIs) and TSCI incidence trends in relation to cause, age, gender, level and completeness of injury. SETTING: Spinal Cord Injury Centre of Western Denmark. METHODS: We reviewed medical records of TSCI patients admitted between 1 January 1990 and 31 December 2012. Proportions, incidence rates and incidence rate ratios were calculated for five time periods; 1990-94, 1995-99, 2000-04, 2005-09 and 2010-12, and were stratified on age, gender, cause, level and completeness of TSCI. TSCI incidence was calculated as the number of new cases divided by person-years at risk. RESULTS: Included were 691 patients (males 81.9%). Within the study period, median age at time of injury rose from 29.0 to 47.5 years. The overall annual TSCI incidence during the study period 1990-94 to 2010-12 was 10.2 per million person-years at risk and varied from 8.3 to 11.8. The proportion of transport-related injuries fell from 56.9% in the first to 36.8% in the most recent time period. Fall-related injuries rose from 11.1 to 35.5%. The proportion of incomplete tetraplegia increased from 32.0% in the first to 40.5% in the last time period. CONCLUSIONS: The overall TSCI incidence is low and remained stable from 1990 to 2012. The proportion of transport-related injuries fell, while age at time of injury and proportion of fall-related injuries and proportion with incomplete tetraplegia all increased.
Asunto(s)
Traumatismos de la Médula Espinal/epidemiología , Accidentes por Caídas/estadística & datos numéricos , Accidentes de Tránsito/estadística & datos numéricos , Accidentes de Tránsito/tendencias , Adolescente , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Traumatismos en Atletas/complicaciones , Traumatismos en Atletas/epidemiología , Niño , Preescolar , Estudios de Cohortes , Dinamarca/epidemiología , Femenino , Hospitalización/estadística & datos numéricos , Hospitalización/tendencias , Humanos , Incidencia , Lactante , Recién Nacido , Masculino , Persona de Mediana Edad , Paraplejía/epidemiología , Paraplejía/etiología , Cuadriplejía/epidemiología , Cuadriplejía/etiología , Traumatismos de la Médula Espinal/complicaciones , Traumatismos de la Médula Espinal/etiología , Adulto JovenRESUMEN
BACKGROUND AND PURPOSE: The aim of the study was to compare the incidence, causes, severity and mortality of traumatic spinal cord injury (TSCI) in Western Norway and Estonia from 1997 to 2001. METHODS: The patients were identified from hospital records. All patients were followed until death or 14 October 2011. Analysed data included demographic data, causes of injury, neurological level, American Spinal Injury Association Impairment Scale and mortality. RESULTS: A total of 71 patients in Western Norway and 244 in Estonia were included. The standardized incidence rate per million was 24.9 (CI 95%, 19.4-31.7) for Western Norway and 37.4 (CI 95%, 32.8-42.5) for Estonia. Falls was the most frequent cause of TSCI in both countries. The incidence of TSCI was highest among men in their 20s in Estonia and men in their 70s in Western Norway. The median survival time among the deceased was 4.0 (95% CI, 1.50-6.50) years in Norway and 2.8 (95% CI, 1.54-4.04) in Estonia. The mean standardized mortality ratio (SMR) was 5.00 (95% CI, 4.00-6.20) in Estonia and 1.89 (95% CI, 1.23-2.77) in Western Norway. CONCLUSION: Although the two cohorts had similar demographic, injury and clinical characteristics, the age profile of the victims was different. The incidence rate was 1.5 times higher and SMR was 2.7 times higher in Estonia. Probable explanations for the different outcomes of the two European countries are socioeconomic differences, lower physical activity level, lower life expectancy and insufficient injury prevention programmes in Estonia.
Asunto(s)
Traumatismos de la Médula Espinal/epidemiología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Preescolar , Estonia/epidemiología , Femenino , Humanos , Incidencia , Esperanza de Vida , Masculino , Persona de Mediana Edad , Actividad Motora , Noruega/epidemiología , Estudios Retrospectivos , Índice de Severidad de la Enfermedad , Caracteres Sexuales , Factores Socioeconómicos , Traumatismos de la Médula Espinal/etiología , Traumatismos de la Médula Espinal/mortalidad , Tasa de SupervivenciaRESUMEN
OBJECTIVE: The objective of this study was to examine how satisfied patients with traumatic spinal cord injury (TSCI) are with their general practitioners (GP). MATERIALS AND METHODS: The study included patients with TSCI, injured in the period 1982-2001 and living in western Norway. We performed a structured telephonic interview of the patients in the period 2004-2007. A total of 105 (59.3%) patients participated. RESULTS: Patients with TSCI were in general satisfied with their GP. Older patients were most satisfied, and patients with incomplete thoracic SCI were least satisfied. Patients with anxiety and/or depression reported low satisfaction with their GP on several parameters. CONCLUSIONS: Patients with incomplete SCI were least satisfied probably because their physicians do not acknowledge their complicated medical complaints and do not meet the patient's expectations. Patients with anxiety and/or depression were more likely to report low satisfaction with their GP.
Asunto(s)
Ansiedad/epidemiología , Depresión/epidemiología , Médicos Generales/estadística & datos numéricos , Satisfacción del Paciente/estadística & datos numéricos , Relaciones Médico-Paciente , Traumatismos de la Médula Espinal/epidemiología , Traumatismos de la Médula Espinal/rehabilitación , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Ansiedad/diagnóstico , Niño , Preescolar , Comorbilidad , Depresión/diagnóstico , Femenino , Humanos , Recién Nacido , Entrevistas como Asunto , Masculino , Persona de Mediana Edad , Noruega/epidemiología , Prevalencia , Traumatismos de la Médula Espinal/diagnóstico , Adulto JovenRESUMEN
OBJECTIVE: A spinal cord injury (SCI) above the sixth thoracic vertebra interrupts the supraspinal control of the sympathetic nervous system causing an imbalance between the sympathetic and the parasympathetic nervous system. This article focuses on the symptoms, treatment and examination of autonomic disturbances of the cardiovascular and the urinary system after a SCI. METHODS: A non-systematic literature search in the PubMed database. RESULTS: Frequent complications in the acute phase of cervical and high thoracic SCI are bradyarrhythmias, hypotension, hypothermia/hyperthermia, increased neurogenic shock, vagovagal reflex, supraventricular/ventricular ectopic beats, vasodilatation and congestion. Serious complications in the chronic phase of SCI are orthostatic hypotension, impaired cardiovascular reflexes, autonomic dysreflexia (AD), reduced sensation of cardiac pain, loss of reflex cardiac acceleration, quadriplegic cardiac atrophy due to loss of left ventricular mass and pseudo-myocardial infarction. AD is associated with a sudden, uncontrolled sympathetic response, triggered by stimuli below the injury. It may cause mild symptoms like skin rash or slight headache, but also severe hypertension, cerebral haemorrhage and death. Early recognition and prompt treatment are important. Urinary autonomic dysfunctions include hyperreflexia or areflexia of detrusor and/or sphincter of the bladder. CONCLUSIONS: Patients with SCI have a high risk of cardiovascular complications, AD and urinary autonomic dysfunction both in the acute phase and later, affecting their prognosis and quality of life. Knowledge of cardiovascular and urological complications after SCI is important for proper diagnosis and treatment.
Asunto(s)
Enfermedades del Sistema Nervioso Autónomo/etiología , Enfermedades Cardiovasculares/etiología , Traumatismos de la Médula Espinal/complicaciones , Enfermedades Urológicas/etiología , Enfermedades del Sistema Nervioso Autónomo/fisiopatología , Enfermedades Cardiovasculares/fisiopatología , Humanos , Traumatismos de la Médula Espinal/fisiopatología , Vértebras Torácicas , Enfermedades Urológicas/fisiopatologíaRESUMEN
OBJECTIVE: The objective of this study is to assess the temporal trends in the incidence and demographic characteristics of traumatic spinal cord injury (TSCI) among children and adolescents in a geographically defined cohort in western Norway during 1952-2001. METHODS: The patients included in this study were identified from the hospital records. RESULTS: Of 336 patients, 13 (3.9%) patients were 0-14 years at time of injury, and 44 (13.1%) patients were 15-19 years at time of injury. The average age-adjusted incidence was 2.4 per million children and 25.1 per million adolescents. Children were injured in car and pedestrian accidents, whereas adolescents were injured in car and motorcycle accidents. CONCLUSIONS: The age-adjusted incidence of TSCI among the adolescents increased, whereas the age-adjusted incidence among children remained low during the 50 years. TSCI was highly associated with car and pedestrian accidents among children. Among adolescents, TSCI was associated with car and motorcycle accidents. Awareness of these factors is important in prevention planning strategies.
Asunto(s)
Traumatismos de la Médula Espinal/diagnóstico , Traumatismos de la Médula Espinal/mortalidad , Accidentes de Tránsito/mortalidad , Accidentes de Tránsito/estadística & datos numéricos , Adolescente , Niño , Preescolar , Estudios de Cohortes , Comorbilidad/tendencias , Femenino , Humanos , Incidencia , Lactante , Recién Nacido , Estudios Longitudinales , Masculino , Noruega/epidemiología , Estudios Retrospectivos , Traumatismos de la Médula Espinal/epidemiología , Índices de Gravedad del Trauma , Adulto JovenRESUMEN
OBJECTIVE: To assess the temporal trends in the incidence and demographic characteristics of traumatic spinal cord injury (TSCI) with clinical concomitant traumatic brain injury (TBI), in an unselected, geographically defined cohort, 1952-2001. MATERIAL AND METHODS: The patients were identified from hospital records. TBI was classified as none, mild, moderate, and severe. RESULTS: Of 336 patients, 157 (46.7%) patients had a clinical concomitant TBI. Clinical TBI was classified as mild in 30.1%, moderate in 11.0% and severe in 5.7%. The average annual incidence increased from 3.3 per million in the first decade to 10.7 per million in the last. Alcohol was the strongest risk factor of clinical TBI (OR = 3.69) followed by completeness of TSCI (OR = 2.18). CONCLUSIONS: The incidence of TSCI with concomitant TBI has increased during the last 50 years. Alcohol and completeness of injury are strong risk factors. Increased awareness of dual diagnoses is necessary.
Asunto(s)
Lesiones Encefálicas/epidemiología , Traumatismos de la Médula Espinal/epidemiología , Adolescente , Adulto , Niño , Preescolar , Estudios de Cohortes , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Adulto JovenRESUMEN
STUDY DESIGN: Retrospective population-based epidemiological study. OBJECTIVE: To assess the prevalence and temporal trends in the incidence of traumatic spinal cord injuries (TSCI), and demographic and clinical characteristics of an unselected, geographically defined cohort in the period 1952-2001. METHODS: The patients were identified from hospital records. Crude rates and age-adjusted rates were calculated for each year. The multivariate relationship between cause of injury, age at injury, decade of injury and gender was examined using a Poisson regression model. RESULTS: Of 336 patients, 199 patients were alive on 1 January 2002, giving a total prevalence of 36.5 per 100,000 inhabitants. The average annual incidence increased from 5.9 per million in the first decade to 21.2 per million in the last. Mean age at injury was 42.9 years and the male to female ratio 4.7:1. Fall was the most common cause of injury (45.5%), followed by motor vehicle accidents (MVA) (34.2%). The incidence of MVA-related injuries increased during the observation period, especially among men <30 years. The lesion level was cervical in 52.4%, thoracic in 29.5% and lumbar/sacral in 18.2%. The lesion was clinically incomplete in 58.6% and complete in 41.4%. The incidence of fall-related injuries and the proportion of incomplete cervical lesions increased during the observation period, especially among men >60 years. CONCLUSIONS: The incidence of TSCI has increased during the past 50 years. Falls and MVA are potentially preventable causes. The increasing proportion of older patients with cervical lesions poses a challenge to the health system.
Asunto(s)
Traumatismos de la Médula Espinal/epidemiología , Adulto , Distribución por Edad , Femenino , Estudios de Seguimiento , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Noruega/epidemiología , Prevalencia , Traumatismos de la Médula Espinal/etiología , Adulto JovenRESUMEN
STUDY DESIGN: Retrospective register study enhanced and verified by medical records. OBJECTIVES: To study whether electronic searches of discharge diagnosis are valid for epidemiological research of traumatic spinal cord injury (SCI), using the International Classification of Diseases (ICD). SETTINGS: Haukeland University Hospital, Bergen, Norway. METHODS: We identified all hospital admissions with discharge codes suggesting a traumatic SCI from ICD-8 to ICD-10 in the electronic database at Haukeland University Hospital, and ascertained the cases by reviewing all hospital records. RESULTS: 1080 patients had an ICD diagnostic code suggesting a traumatic SCI. Only 260 were verified when reviewing the hospital records. The ICD-10 codes had superior positive predictive values (PPV) and likelihood ratios (LR+) compared with the codes from ICD-8 and ICD-9. Combining seven codes from ICD-10 (S14.0, S14.1, S24.0, S24.1, S34.1, S34.3, T91.3) gave the highest sensitivity (0.83), specificity (0.97), PPV (0.88) and LR+ (30.23). CONCLUSION: Obtaining hospital discharge diagnoses solely from electronic databases overestimates the incidence of traumatic SCI. Identification of patients using ICD-10 codes is more complicated because acute traumatic SCI and traumatic SCI sequelae are listed with several codes. The latest ICD version proved to be most reliable when identifying patients with traumatic SCI. However, ICD data cannot be trusted without extensive validity checks for either research or for health planning and administration.
Asunto(s)
Grupos Diagnósticos Relacionados , Control de Formularios y Registros/métodos , Clasificación Internacional de Enfermedades/estadística & datos numéricos , Sistemas de Registros Médicos Computarizados/estadística & datos numéricos , Alta del Paciente/estadística & datos numéricos , Traumatismos de la Médula Espinal/diagnóstico , Traumatismos de la Médula Espinal/epidemiología , Hospitales Universitarios , Humanos , Noruega/epidemiología , Valor Predictivo de las Pruebas , Sistema de Registros , Reproducibilidad de los Resultados , Estudios Retrospectivos , Sensibilidad y EspecificidadRESUMEN
OBJECTIVES: To study the causes and the rehabilitation outcome of traumatic spinal cord injury (SCI) in patients older than 60 years at the time of injury. MATERIAL: Forty-four patients were included. METHODS: The American Spinal Injury Association Motor Impairment Scale on admission and at discharge and the Functional Independence Measure Motor subscale at discharge were calculated retrospectively according to the patient records. The causes of injury and treatment were obtained. The MRI-scans in patients with cervical injuries during the last 5 years were evaluated. RESULTS: Thirty-four patients (77%) were injured after falling from a height, 24 with cervical lesions. Thirty-five patients (80%) had incomplete lesions and they had the best outcome with regard to functional level. MR images of 15 patients with cervical lesions revealed preexisting cervical stenosis in 80%. CONCLUSIONS: A high proportion of the patients had a cervical spinal stenosis and incomplete SCI; most of them regained good function.
Asunto(s)
Traumatismos de la Médula Espinal/epidemiología , Traumatismos de la Médula Espinal/rehabilitación , Médula Espinal/patología , Factores de Edad , Anciano , Vértebras Cervicales/lesiones , Vértebras Cervicales/patología , Comorbilidad , Femenino , Hospitalización/estadística & datos numéricos , Humanos , Desplazamiento del Disco Intervertebral/epidemiología , Desplazamiento del Disco Intervertebral/patología , Luxaciones Articulares/epidemiología , Luxaciones Articulares/patología , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Noruega , Factores de Riesgo , Médula Espinal/fisiopatología , Traumatismos de la Médula Espinal/patología , Fracturas de la Columna Vertebral/epidemiología , Fracturas de la Columna Vertebral/patología , Estenosis Espinal/epidemiología , Estenosis Espinal/patología , Resultado del TratamientoRESUMEN
BACKGROUND: Metoclopramide is an antiemetic drug used frequently both in general practice and hospitals. The drug has few side effects, mainly drowsiness, and can be used both in pregnancy and breastfeeding. Acute dystonia is a rare side effect mostly affecting children and young adults within 1-3 days after start of the medication. Women are more frequently affected than men. MATERIAL AND METHODS: We present a clinical description of two patients admitted to our department with acute dystonia precipitated by metoclopramide. RESULTS: Both patients received treatment with biperiden; one received additional benzodiazepine. Both recovered rapidly and were discharged symptom free the next day. INTERPRETATION: Metoclopramide-induced dystonia is frightening both for the patient and the family. Because of concomitant anxiety and psychiatric symptoms, individuals are often regarded as hysterical. The attack can be abbreviated by parenteral administration of anticholinergic drugs. It is important that all doctors prescribing metoclopramide know of this side effect, especially when their patients are young females.
Asunto(s)
Antieméticos/efectos adversos , Discinesia Inducida por Medicamentos/etiología , Metoclopramida/efectos adversos , Enfermedad Aguda , Adulto , Femenino , Humanos , Masculino , EmbarazoRESUMEN
BACKGROUND: We wanted to study the cause and the segmental level of traumatic spinal cord injuries. MATERIAL AND METHODS: All 238 patients (208 men) with traumatic spinal cord injuries admitted to the Department of Neurology, Haukeland University Hospital in Bergen, Norway, from 1952 to 1999 were included. Data were obtained from medical files and studied retrospectively. RESULTS: The initial clinical level of injury was the cervical spine in 50% of the patients, the thoracic spine in 33%, and the lumbar spine in 18%. Falling (45%) and road accidents (35%) were the main causes. The mean annual number of patients with traumatic spinal cord injuries increased from three in 1952-60 to eight in 1991-99; there was an increase in high cervical injuries among those older than 60. The proportion of work-related traumatic spinal cord injuries was 42% in 1952-74 and 26% in 1975-99. INTERPRETATION: Although there has been a reduction of work-related spinal cord injuries, there is still a potential for further prevention, especially among persons of more than 60 years of age.
Asunto(s)
Traumatismos de la Médula Espinal/epidemiología , Traumatismos de la Médula Espinal/etiología , Accidentes por Caídas/estadística & datos numéricos , Accidentes de Trabajo/estadística & datos numéricos , Accidentes de Tránsito/estadística & datos numéricos , Adolescente , Adulto , Anciano , Niño , Femenino , Humanos , Lactante , Masculino , Persona de Mediana Edad , Noruega/epidemiología , Pronóstico , Estudios Retrospectivos , Traumatismos de la Médula Espinal/terapiaRESUMEN
STUDY DESIGN: A controlled randomized clinical trial was performed. OBJECTIVE: To investigate the effect of a light mobilization program on the duration of sick leave for patients with subacute low back pain. SUMMARY OF BACKGROUND DATA: Early intervention with information, diagnostics, and light mobilization may be a cost-effective method for returning patients quickly to normal activity. In this experiment, patients were referred to a low back pain clinic and given this simple and systematic program as an outpatient treatment. METHODS: In this study, 457 patients sick-listed 8 to 12 weeks for low back pain, as recorded by the National Insurance Offices, were randomized into two groups: an intervention group (n = 237) and a control group (n = 220). The intervention group was examined at a spine clinic and given information and advice to stay active. The control group was not examined at the clinic, but was treated with conventional primary health care. RESULTS: At 12-month follow-up assessment, 68.4% in the intervention group had returned to full-duty work, as compared with 56.4% in the control group. CONCLUSIONS: Early intervention with examination, information, and recommendations to stay active showed significant effects in reducing sick leave for patients with low back pain.
Asunto(s)
Terapia por Ejercicio , Dolor de la Región Lumbar/rehabilitación , Ausencia por Enfermedad , Adolescente , Adulto , Evaluación de la Discapacidad , Femenino , Estudios de Seguimiento , Humanos , Región Lumbosacra/fisiología , Masculino , Persona de Mediana Edad , Pacientes Ambulatorios , Educación del Paciente como Asunto , Evaluación de Capacidad de Trabajo , Indemnización para TrabajadoresRESUMEN
During the period from May 1997 to October 1998, eight patients with coeliac disease or dermatitis herpetiformis and neurological disorders were admitted to the Department of Neurology, University Hospital of Bergen. The most frequent conditions were polyneuropathy (seven patients) and spinocerebellar ataxia (three patients). Other conditions were lower motor neuron disease, myelopathy, epilepsy and encephalopathy. The patients used various degrees of gluten-free diet at the time of admission. It remains unclear whether there is a shared common pathogenetic mechanism or the neurological disorder is a complication to the coeliac disease. Both vitamin depletion and immunological mechanisms may cause neurological disorder. Neurological manifestations may occur before the gastrointestinal symptoms. With reference to our patients and available literature we discuss prevalence, clinical picture, pathogenesis, treatment and prognosis. Neurologists, gastroenterologists and general practitioners should be aware that coeliac disease can cause neurological diseases, especially polyneuropathy, cerebellar ataxia and encephalopathy.