RESUMEN
Cryostorage of reproductive potential, in the form of ovarian cortex, for young women about to undergo cytotoxic therapies has been offered clinically for some time. However, the prospects of re-establishing reproductive function using this tissue remain unclear. We now report reproducible follicular development, oocyte retrieval and embryo development following heterotopic grafting of cryopreserved ovarian cortex which had been stored for over 10 years.
Asunto(s)
Criopreservación , Ovario/fisiología , Ovario/trasplante , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Australia , Gonadotropina Coriónica Humana de Subunidad beta/sangre , Ciclofosfamida/uso terapéutico , Doxorrubicina/uso terapéutico , Estradiol/uso terapéutico , Femenino , Hormona Folículo Estimulante/sangre , Humanos , Hormona Luteinizante/sangre , Linfoma Anaplásico de Células Grandes/tratamiento farmacológico , Prednisona/uso terapéutico , Progesterona/sangre , Inyecciones de Esperma Intracitoplasmáticas , Trasplante Autólogo , Resultado del Tratamiento , Vincristina/uso terapéuticoRESUMEN
We describe the case of a woman with some features of the MURCS (Müllerian duct aplasia, renal aplasia, and cervicothoracic somite dysplasia) association, along with a radial ray anomaly. She had fusion of two cervical vertebrae, and a unicornuate uterus as MURCS components; and thenar muscle hypoplasia and absent radial pulses reflecting radial ray elements. We review two similar cases from the literature. We discuss whether our case might represent an incomplete and variant form of the MURCS association, or an example of an overlap between the MURCS and VATER (vertebral, anal, tracheo-esophageal, radial) associations.