Batch fabrication process of biomimetic wing with high flexibility of stiffness design for flapping-wing micro aerial vehicles.

A lamination-based batch-fabrication process of biomimetic wing for flapping-wing micro aerial vehicles is presented. The key benefits of this process are:•One of the advantages of the process is high productivity; eight wings were successfully fabricated simultaneously in our experiment.•The wing fabricated with the reported process is made of soft polyimide and partially reinforced by a titanium layer. This configuration enables the flexible design of the bending stiffness distribution on the wing, which is the key specification for generating lift force.•The reinforcing material can be replaced with other metals or heat-resistant polymers, and the number of layers and layer thicknesses are also variable. This indicates that the reported process can be customized considerably to suit individual needs.

Analysis of adipose tissues and stromal vascular cells in a murine arthritis model.

PURPOSE: Changes in body composition in rheumatoid arthritis (RA), including a reduction in skeletal muscle mass and the accumulation of visceral fat, have been identified, and the interaction between immune abnormality and metabolic disorders has received much attention. The effect of a high-fat (HF) diet and the role of adipose tissue in an arthritis model were investigated. METHODS: The effect of an HF diet on the histopathology of joints in murine type II collagen-induced arthritis (CIA) was evaluated. The morphology and adipokine production of adipose tissues were analyzed, and macrophages in the stromal vascular fraction (SVF) were counted by flow cytometry. Serum adipokine levels were measured by ELISA. RESULTS: Significant exacerbation of joint destruction and aggravated pathological conditions were observed in CIA mice that were fed an HF diet. However, the boundary length of adipose tissue tended to decrease and the levels of adipokines (leptin and adiponectin) were lowered by the induction of arthritis. In HF/CIA mice, nevertheless, the production of MCP-1 in adipose tissues and the accumulation of macrophages in the SVF were significantly higher than CON/CIA group. The serum leptin/adiponectin (L/A) ratio was positively correlated with the number of macrophages in the SVF and MCP-1 production by adipose tissue, particularly in the CIA group. CONCLUSION: Functional alterations of adipose tissues could be originated from HF diet during developing arthritis. An abnormal activation of macrophages and an increased production of MCP-1 in adipose tissues might be both involved in joint destruction and inflammation.