Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 5 de 5
Filtrar
Más filtros










Base de datos
Intervalo de año de publicación
1.
Dalton Trans ; 42(34): 12346-53, 2013 Sep 14.
Artículo en Inglés | MEDLINE | ID: mdl-23860908

RESUMEN

A series of novel binuclear phenoxyimino organoaluminum complexes of the type [(RN=CH)C6H3OAlMe2]2 [R = C6H5 (2a), 2,6-(i)Pr2C6H3 (2b), 2,6-Ph2C6H3 (2c), adamantyl (2d), (t)Bu (2e)] have been prepared in high yields, and these complexes were identified by (1)H, (13)C NMR and elemental analysis. Structural analysis for 2a-e revealed that these complexes have a distorted tetrahedral geometry around Al and both the Al-O and the Al-N bond distances were considerably influenced by substituents in the imino groups. The complexes were tested as catalyst precursors for ring-opening polymerisation (ROP) of ε-caprolactone (CL) in the presence of BnOH, and their catalytic activities were strongly affected by the catalyst structures and polymerisation conditions. An efficient living ROP has been achieved using the 2b/BnOH system.


Asunto(s)
Aluminio/química , Caproatos/química , Complejos de Coordinación/química , Lactonas/química , Compuestos Organometálicos/química , Catálisis , Complejos de Coordinación/síntesis química , Cristalografía por Rayos X , Conformación Molecular , Polimerizacion
2.
Zhonghua Yi Xue Za Zhi ; 92(18): 1278-80, 2012 May 15.
Artículo en Chino | MEDLINE | ID: mdl-22883069

RESUMEN

OBJECTIVE: To summarize the clinical characteristics and outcomes of Pseudo-Bartter's syndrome and explore its pathogenesis. METHODS: The clinical data of 5 cases of Pseudo-Bartter's syndrome at our ward from May 2008 to December 2010 was analyzed retrospectively. RESULTS: All patients were female. Long-term regimen of purgative or diuretics was prescribed. The clinical features included normotension, hypokalemic alkalosis and activation of renin-angiotensin-aldosterone. The pathological results of 3 cases of kidney biopsy showed the hyperplasia of juxtaglomerular apparatus, thickness of arteriole, infiltration of lymphocytes and monocytes and degeneration of renal tubule. Upon a definitive diagnosis, purgative or diuretics was discontinued and supplement therapy of potassium chloride initiated. The results of laboratory tests reverted to normal ranges within 4 weeks. CONCLUSION: Purgative or diuretics should be prescribed appropriately to avoid the occurrence of Pseudo-Bartter's syndrome.


Asunto(s)
Síndrome de Bartter/inducido químicamente , Catárticos/efectos adversos , Diuréticos/efectos adversos , Adulto , Síndrome de Bartter/diagnóstico , Femenino , Humanos , Persona de Mediana Edad , Estudios Retrospectivos
3.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi ; 29(2): 141-4, 2012 Apr.
Artículo en Chino | MEDLINE | ID: mdl-22487820

RESUMEN

OBJECTIVE: To identify potential mutation of apolipoprotein E (apoE) gene in a male patient affected with lipoprotein glomerulopathy (LPG), his mother and his sister. METHODS: The patient and his mother both had histologically confirmed LPG. His sister and his father were asymptomatic. Genomic DNA was extracted from peripheral blood samples. PCR products of the coding region of exons 3 and 4 of the apoE gene were cloned into a pTA2 vector and sequenced. Genetic variations of the apoE gene were detected using PCR and restriction fragment length polymorphism (RFLP). RESULTS: An apoE gene mutation was identified in the patient's family. Sequence analysis confirmed a 9-bp deletion in the exon 4 of apoE gene from nt 484 to 492. The 9-bp deletion resulted in loss of 3 amino acids at positions 143-145. The sister of the propositus carried the same mutation, though she had neither proteinuria nor elevated plasma apoE. Sequence analysis of exon 3 showed no abnormality. No abnormalities were found in the father's apoE gene sequence. Analysis of genetic variations of the apoE gene by PCR and RFLP confirmed a 57 bp fragment consistent with the 9-bp deletion in exon 4. The father had a normal ε 3 ε 3 genotype. CONCLUSION: The 9 bp deletion of apoE may be associated with the pathogenesis of LPG.


Asunto(s)
Apolipoproteínas E/genética , Exones , Enfermedades Renales/genética , Lipoproteínas/sangre , Mutación , Adolescente , Apolipoproteínas E/sangre , Femenino , Predisposición Genética a la Enfermedad , Variación Genética , Humanos , Enfermedades Renales/sangre , Glomérulos Renales/metabolismo , Glomérulos Renales/patología , Masculino , Linaje
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...