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1.
Environ Sci Technol ; 58(1): 33-42, 2024 Jan 09.
Artículo en Inglés | MEDLINE | ID: mdl-38109378

RESUMEN

Electrifying freight trucks will be key to alleviating air pollution burdens on disadvantaged communities and mitigating climate change. The United States plans to pursue this aim by adding vehicle charging infrastructure along specific freight corridors. This study explores the coevolution of the electricity grid and freight trucking landscape using an integrated assessment framework to identify when each interstate and drayage corridor becomes advantageous to electrify from a climate and human health standpoint. Nearly all corridors achieve greenhouse gas emission reductions if electrified now. Most can reduce health impacts from air pollution if electrified by 2040 although some corridors in the Midwest, South, and Mid-Atlantic regions remain unfavorable to electrify from a human health standpoint, absent policy support. Recent policy, namely, the Inflation Reduction Act, accelerates this timeline to 2030 for most corridors and results in net human health benefits on all corridors by 2050, suggesting that near-term investments in truck electrification, particularly drayage corridors, can meaningfully reduce climate and health burdens.


Asunto(s)
Contaminantes Atmosféricos , Contaminación del Aire , Gases de Efecto Invernadero , Estados Unidos , Humanos , Emisiones de Vehículos/análisis , Vehículos a Motor , Contaminación del Aire/análisis , Electricidad , Contaminantes Atmosféricos/análisis
4.
Environ Sci Technol ; 57(49): 20689-20698, 2023 Dec 12.
Artículo en Inglés | MEDLINE | ID: mdl-38033264

RESUMEN

The extent to which emission control technologies and policies have reduced anthropogenic NOx emissions from motor vehicles is large but uncertain. We evaluate a fuel-based emission inventory for southern California during the June 2021 period, coinciding with the Re-Evaluating the Chemistry of Air Pollutants in CAlifornia (RECAP-CA) field campaign. A modified version of the Fuel-based Inventory of Vehicle Emissions (FIVE) is presented, incorporating 1.3 km resolution gridding and a new light-/medium-duty diesel vehicle category. NOx concentrations and weekday-weekend differences were predicted using the WRF-Chem model and evaluated using satellite and aircraft observations. Model performance was similar on weekdays and weekends, indicating appropriate day-of-week scaling of NOx emissions and a reasonable distribution of emissions by sector. Large observed weekend decreases in NOx are mainly due to changes in on-road vehicle emissions. The inventory presented in this study suggests that on-road vehicles were responsible for 55-72% of the NOx emissions in the South Coast Air Basin, compared to the corresponding fraction (43%) in the planning inventory from the South Coast Air Quality Management District. This fuel-based inventory suggests on-road NOx emissions that are 1.5 ± 0.4, 2.8 ± 0.6, and 1.3 ± 0.7 times the reference EMFAC model estimates for on-road gasoline, light- and medium-duty diesel, and heavy-duty diesel, respectively.


Asunto(s)
Contaminantes Atmosféricos , Emisiones de Vehículos , Emisiones de Vehículos/análisis , Los Angeles , Monitoreo del Ambiente , Contaminantes Atmosféricos/análisis , Gasolina/análisis , Vehículos a Motor , Óxidos de Nitrógeno/análisis
5.
Environ Sci Technol ; 57(26): 9693-9701, 2023 07 04.
Artículo en Inglés | MEDLINE | ID: mdl-37329338

RESUMEN

The effects of precursor emission controls on air quality can vary greatly depending on where emission reductions occur. We use the adjoint of the Community Multiscale Air Quality (CMAQ) model to evaluate impacts of spatially targeted NOx emission reductions on odd oxygen (Ox = O3 + NO2). The air quality responses studied here include one population-weighted regionwide and three city-level receptors in Central California. We map high-priority locations for NOx control and their changes over decadal time scales. The desirability of NOx-focused emission control programs has increased between 2000 and 2022. We find for present-day conditions that reducing NOx emissions by 28% from targeted high-priority locations can achieve 60% of the air quality benefits of uniform NOx reductions at all locations. High-priority source locations are found to differ for individual city-level versus regionwide receptors of interest. While high-impact emission hotspots for improving city-level metrics are found within the city itself or closely adjacent, the spatial pattern of emission hotspots for improving regionwide air quality is more complex and requires comprehensive consideration of upwind sources. Results of this study can help to inform strategic decision-making at local and regional levels about where to prioritize emission control efforts.


Asunto(s)
Contaminantes Atmosféricos , Contaminación del Aire , Ozono , Compuestos Orgánicos Volátiles , Contaminantes Atmosféricos/análisis , Ozono/análisis , Óxidos de Nitrógeno/análisis , Compuestos Orgánicos Volátiles/análisis , Contaminación del Aire/prevención & control , Contaminación del Aire/análisis , Oxígeno , Monitoreo del Ambiente/métodos
6.
Environ Sci Technol ; 56(11): 7074-7082, 2022 06 07.
Artículo en Inglés | MEDLINE | ID: mdl-35467865

RESUMEN

Ground-level ozone adversely affects human health and ecosystems. The effectiveness of control programs depends on which precursor(s) are controlled, by how much, and where and when emission reductions occur. We use the adjoint of the Community Multiscale Air Quality model to investigate odd oxygen (Ox ≡ O3 + NO2) sensitivities in California's San Joaquin Valley (SJV) to precursor emissions from local and upwind sources. Sensitivities are mapped and disaggregated by hour and day. Taken together, impacts of precursor emissions in the San Francisco Bay area and Sacramento Valley are similar in magnitude to impacts of local SJV emissions. Same-day emission sensitivities are mostly attributable to local sources, with the most influential anthropogenic emissions of VOCs (volatile organic compounds) and NOx (nitrogen oxides) occurring in the morning (9-11 am) and early afternoon hours (1-3 pm), respectively. For the northernmost SJV receptor, the influence from Sacramento Valley emissions peaks 5-6 h later than Bay area emissions; this difference diminishes for SJV receptors located further downwind. Results show a shift toward more NOx-sensitive conditions in the afternoon with all but the southernmost receptor shifting from VOC- to NOx-sensitive conditions. We also evaluate opportunities to control pollution through shifts in precursor emission location and timing.


Asunto(s)
Contaminantes Atmosféricos , Contaminación del Aire , Ozono , Compuestos Orgánicos Volátiles , Contaminantes Atmosféricos/análisis , Ecosistema , Monitoreo del Ambiente/métodos , Humanos , Ozono/química , San Francisco
8.
Environ Sci Technol ; 55(18): 12250-12260, 2021 09 21.
Artículo en Inglés | MEDLINE | ID: mdl-34505515

RESUMEN

Exposure to diesel-related air pollution, which includes black carbon (BC) as a major component of the particulate matter emitted in engine exhaust, is a known human health hazard. The resulting health burden falls heavily on vulnerable communities located close to major sources including highways, rail yards, and ports. Determination of source contributions to the overall pollution burden is challenging due to collinearity in the exhaust composition profiles for relevant sources including heavy-duty diesel trucks, railroad locomotives, cargo-handling equipment, and marine engines. Additionally, the impact of each source depends not just on the magnitude of emissions but on its location relative to receptors as well as on meteorology. We modeled source-resolved BC concentrations in West Oakland, California, at a high (150 m) spatial resolution using the Weather Research and Forecasting model. The ability of the model to predict hourly and 24 h average BC concentrations is evaluated for a 100-day period in summer 2017 when BC was measured at 100 sites within the community. We find that a community monitoring site is representative of population-weighted average BC exposure in the community. Major contributing sources to BC in West Oakland include on-road diesel trucks (44 ± 5%) and three off-road diesel sources: ocean-going vessels (19 ± 1%), railroad locomotives (16 ± 2%), and harbor craft such as tugboats and ferries (11 ± 1%).


Asunto(s)
Contaminantes Atmosféricos , Contaminantes Atmosféricos/análisis , Carbono , Monitoreo del Ambiente , Humanos , Material Particulado/análisis , Emisiones de Vehículos/análisis
9.
Environ Sci Technol ; 55(10): 6655-6664, 2021 05 18.
Artículo en Inglés | MEDLINE | ID: mdl-33951912

RESUMEN

On-road vehicles continue to be a major source of nitrogen oxide (NOx) emissions in the United States and in other countries around the world. The goal of this study is to compare and evaluate emission inventories and long-term trends in vehicular NOx emissions. Taxable fuel sales data and in-use measurements of emission factors are combined to generate fuel-based NOx emission inventories for California and the US over the period 1990-2020. While gasoline and diesel fuel sales increased over the last three decades, total on-road NOx emissions declined by approximately 70% since 1990, with a steeper rate of decrease after 2004 when heavy-duty diesel NOx emission controls finally started to gain traction. In California, additional steps have been taken to accelerate the introduction of new heavy-duty engines equipped with selective catalytic reduction systems, resulting in a 48% decrease in diesel NOx emissions in California compared to a 32% decrease nationally since 2010. California EMFAC model predictions are in good agreement with fuel-based inventory results for gasoline engines and are higher than fuel-based estimates for diesel engines prior to the mid-2010s. Similar to the findings of recent observational and modeling studies, there are discrepancies between the fuel-based inventory and national MOVES model estimates. MOVES predicts a steeper decrease in NOx emissions and predicts higher NOx emissions from gasoline engines over the entire period from 1990 to 2020.


Asunto(s)
Contaminantes Atmosféricos , Gasolina , Contaminantes Atmosféricos/análisis , Monitoreo del Ambiente , Gasolina/análisis , Vehículos a Motor , Óxidos de Nitrógeno/análisis , Emisiones de Vehículos/análisis
10.
Environ Sci Technol ; 53(24): 14568-14576, 2019 12 17.
Artículo en Inglés | MEDLINE | ID: mdl-31686501

RESUMEN

Emissions from thousands of in-use heavy-duty diesel trucks were sampled at a highway and an arterial street location in the San Francisco Bay Area, spanning a time period when use of diesel particle filters (DPFs) and selective catalytic reduction (SCR) increased rapidly. At the highway site where a diverse mix of trucks is observed, SCR systems on 2010 and newer engines reduce emitted nitrogen oxides (NOx) by 87 ± 5% relative to pre-2004 engines. SCR also mitigates DPF-related increases in nitrogen dioxide (NO2) emissions. However, a majority of trucks had in-use NOx emission rates that exceeded applicable emission standards. SCR systems increase emissions of nitrous oxide (N2O) and ammonia (NH3) from near-zero levels to 0.93 ± 0.13 and 0.18 ± 0.07 g kg-1, respectively. Emissions of all nitrogenous species and especially NH3 are skewed; 10% of trucks contribute 95% of the on-road fleet's total NH3 emissions. Similar emission changes are observed at the arterial street site where exclusively drayage trucks operate. The environmental effects of decreased black carbon, NOx, and carbon dioxide (CO2) emissions and increased N2O and NH3 emissions due to the rapid adoption of DPF and SCR systems by the California truck fleet are: (1) a 65% net decrease in the social cost of statewide exposure to diesel truck emissions (-3.3 billion 2018 US dollars per year), and (2) a 3% net decrease in the global warming potential-weighted emission factor (-27 g CO2-eq km-1).


Asunto(s)
Contaminantes Atmosféricos , Emisiones de Vehículos , Ambiente , Monitoreo del Ambiente , Vehículos a Motor , Nitrógeno , San Francisco
11.
Artículo en Inglés | MEDLINE | ID: mdl-31652720

RESUMEN

Freeway rerouting and replacement with a street-level boulevard are urban transportation policies, that may help redress disproportionate air pollution burdens resulting from freeway construction that took place during the mid-20th century. However, environmental justice activism for freeway rerouting and urban green space creation may have the unintended consequence of environmental gentrification. In this paper, we investigate the effects of freeway routing decisions on exposure to traffic-related air pollution and neighborhood socioeconomic and demographic change. We focus on the effects of rerouting the Cypress Freeway in West Oakland, along with the construction of a street-level boulevard (Mandela Parkway), on the original freeway alignment. The impacts of two rebuild scenarios, freeway rebuild-in-place and reroute, on near-roadway NOx and BC concentrations are compared. We also assess changes in demographics and land use in West Oakland, between the time when the Cypress Freeway was damaged by a major earthquake and after completion of Mandela Parkway. Our research indicates that freeway rerouting reduced annual average concentrations of both NOx (-38% ± 4%) and BC (-25% ± 2%) along the Mandela Parkway alignment. However, there is evidence of environmentally driven neighborhood change, given that there are larger decreases in the long-time Black population (-28%) and increases in property values (184%) along Mandela Parkway, compared to West Oakland as a whole. There are some attributes along the Mandela Parkway that enable low-income residents to live in proximity to the street-level boulevard, such as affordable housing.


Asunto(s)
Contaminantes Atmosféricos/análisis , Contaminación del Aire/estadística & datos numéricos , Planificación Ambiental , Exposición a Riesgos Ambientales/estadística & datos numéricos , Características de la Residencia , Emisiones de Vehículos/análisis , Contaminación del Aire/análisis , California , Exposición a Riesgos Ambientales/análisis , Monitoreo del Ambiente/métodos , Humanos , Salud Urbana
12.
Vox Sang ; 114(7): 687-693, 2019 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-31396975

RESUMEN

BACKGROUND AND OBJECTIVES: There is conflicting evidence in the literature as to whether there is a blood-borne virus (BBV) risk associated with tattoos in licensed premises. However, blood donors are currently deferred from blood donation in Australia for 4 months after any tattoo. We aimed to assess the incidence of BBVs in blood donors who declared tattoos and evaluate the risk to blood safety through risk modelling. MATERIALS AND METHODS: Donors from 2013 to 2016 with a tattoo deferral on their blood donor file with pre- and post-BBV testing were analysed to determine an incidence of BBVs using standard methods. This was compared to a 2014 cohort of whole blood donors with a deferral of 4 months due to travel to a malaria-endemic area. Using the incidence of tattoos and BBV risk, the total residual risk estimate of allowing tattooed donors to return without restriction was calculated. RESULTS: The incidence rate of BBVs in blood donors following tattoo deferral was 13·26 (95% CI 2·67-38·75) per 100 000 person-years (all were hepatitis C infections in males compared to 9·26 (95% CI 2·49-23·71) per 100 000 in blood donors following malaria deferral. If other risk factors were accounted for the risk in tattoo donors decreased to 4·4 per 100 000 person-years. The total residual risk calculation if donors with a tattoo were allowed to donate without restriction was estimated at 1 in 34 million. CONCLUSIONS: This residual risk indicates BBV deferral for donors post-tattoo in Australia is not required for blood safety.


Asunto(s)
Donantes de Sangre/estadística & datos numéricos , Seguridad de la Sangre/estadística & datos numéricos , Hepatitis C/epidemiología , Malaria/epidemiología , Tatuaje/estadística & datos numéricos , Adulto , Australia , Seguridad de la Sangre/normas , Femenino , Humanos , Masculino , Medición de Riesgo , Tatuaje/efectos adversos
13.
Transfusion ; 59(7): 2368-2374, 2019 07.
Artículo en Inglés | MEDLINE | ID: mdl-31070793

RESUMEN

BACKGROUND: A fatal case of autochthonous Babesia microti infection was reported in Australia in 2012. This has implications for Australian public health and, given that babesiosis is transfusion transmissible, has possible implications for Australian blood transfusion recipients. We investigated the seroprevalence of antibodies to B. microti in Australian blood donors and in patients with clinically suspected babesiosis. STUDY DESIGN AND METHODS: Plasma samples (n = 7,000) from donors donating in at-risk areas and clinical specimens from patients with clinically suspected babesiosis (n = 29) were tested for B. microti IgG by immunofluorescence assay (IFA). IFA initially reactive samples were tested for B. microti IgG and IgM by immunoblot and B. microti DNA by polymerase chain reaction. RESULTS: Although five donors were initially reactive for B. microti IgG by IFA, none was confirmed for B. microti IgG (zero estimate; 95% confidence interval, 0%-0.05%) and all were negative for B. microti DNA. None of the patient samples had B. microti IgG, IgM, or DNA. CONCLUSIONS: This study does not provide evidence for widespread exposure to B. microti in Australian blood donors at local theoretical risk, nor does it provide evidence of B. microti infection in Australian patients with clinically suspected babesiosis. Given that confirmed evidence of previous exposure to B. microti was not seen, these data suggest that transmission of this pathogen is currently uncommon in Australia and unlikely to pose a risk to transfusion safety at present.


Asunto(s)
Anticuerpos Antiprotozoarios/sangre , Babesia microti , Babesiosis , Donantes de Sangre , Seguridad de la Sangre , Transfusión Sanguínea , ADN Protozoario/sangre , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Australia/epidemiología , Babesiosis/sangre , Babesiosis/epidemiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Seroepidemiológicos
14.
Environ Sci Technol ; 52(20): 11913-11921, 2018 10 16.
Artículo en Inglés | MEDLINE | ID: mdl-30153019

RESUMEN

Diesel particle filters (DPFs) are standard equipment on heavy-duty diesel trucks with 2007 and newer engines in the U.S. This study evaluates the performance and durability of these filters. Black carbon (BC) emission rates from several thousand heavy-duty trucks were measured at the Port of Oakland and Caldecott Tunnel over multiple years as California regulations accelerated the adoption of DPFs. As DPF use increased, fleet-average BC emissions decreased, and emission factor distributions became more skewed. Relative to 2004-2006 engines without filters, DPFs reduced BC emission rates by 65-70% for 2007-2009 engines and by >90% for 2010+ engines. Average BC emission rates for 2007-2009 engines increased by 50-67% in 2015 relative to measurements made 1-2 years earlier. Some trucks in this cohort have become high-emitters, indicating that some DPFs are no longer working well. At the Port, where DPFs were universal in 2015, high-emitting 2007-2009 engines (defined here as emitting >1 g BC kg-1) comprised 7% of the fleet but were responsible for 65% of the total BC emitted. These observations raise concerns about DPF durability and the prospects for fully mitigating adverse effects of diesel particulate matter on human health and the environment.


Asunto(s)
Contaminantes Atmosféricos , Emisiones de Vehículos , California , Vehículos a Motor , Material Particulado
15.
Science ; 359(6377): 760-764, 2018 02 16.
Artículo en Inglés | MEDLINE | ID: mdl-29449485

RESUMEN

A gap in emission inventories of urban volatile organic compound (VOC) sources, which contribute to regional ozone and aerosol burdens, has increased as transportation emissions in the United States and Europe have declined rapidly. A detailed mass balance demonstrates that the use of volatile chemical products (VCPs)-including pesticides, coatings, printing inks, adhesives, cleaning agents, and personal care products-now constitutes half of fossil fuel VOC emissions in industrialized cities. The high fraction of VCP emissions is consistent with observed urban outdoor and indoor air measurements. We show that human exposure to carbonaceous aerosols of fossil origin is transitioning away from transportation-related sources and toward VCPs. Existing U.S. regulations on VCPs emphasize mitigating ozone and air toxics, but they currently exempt many chemicals that lead to secondary organic aerosols.


Asunto(s)
Contaminantes Atmosféricos/efectos adversos , Exposición a Riesgos Ambientales , Hidrocarburos/efectos adversos , Compuestos Orgánicos Volátiles/efectos adversos , Contaminantes Atmosféricos/análisis , Ácido Dioctil Sulfosuccínico , Humanos , Hidrocarburos/análisis , Estados Unidos , Compuestos Orgánicos Volátiles/análisis
16.
Transfusion ; 58(2): 485-492, 2018 02.
Artículo en Inglés | MEDLINE | ID: mdl-29350414

RESUMEN

BACKGROUND: Emerging transfusion-transmissible pathogens, including arboviruses such as West Nile, Zika, dengue, and Ross River viruses, are potential threats to transfusion safety. The most prevalent arbovirus in humans in Australia is Ross River virus (RRV); however, prevalence varies substantially around the country. Modeling estimated a yearly risk of 8 to 11 potentially RRV-viremic fresh blood components nationwide. This study aimed to measure the occurrence of RRV viremia among donors who donated at Australian collection centers located in areas with significant RRV transmission during one peak season. STUDY DESIGN AND METHODS: Plasma samples were collected from donors (n = 7500) who donated at the selected collection centers during one peak season. Viral RNA was extracted from individual samples, and quantitative reverse transcription-polymerase chain reaction was performed. RESULTS: Regions with the highest rates of RRV transmission were not areas where donor centers were located. We did not detect RRV RNA among 7500 donations collected at the selected centers, resulting in a zero risk estimate with a one-sided 95% confidence interval of 0 to 1 in 2019 donations. CONCLUSION: Our results suggest that the yearly risk of collecting a RRV-infected blood donation in Australia is low and is at the lower range of previous risk modeling. The majority of Australian donor centers were not in areas known to be at the highest risk for RRV transmission, which was not taken into account in previous models based on notification data. Therefore, we believe that the risk of RRV transfusion transmission in Australia is acceptably low and appropriately managed through existing risk management, including donation restrictions and recall policies.


Asunto(s)
Infecciones por Alphavirus/sangre , Donantes de Sangre , Seguridad de la Sangre , ARN Viral/sangre , Virus del Río Ross , Infecciones por Alphavirus/epidemiología , Australia/epidemiología , Femenino , Humanos , Masculino
17.
Environ Sci Technol ; 51(3): 1074-1093, 2017 02 07.
Artículo en Inglés | MEDLINE | ID: mdl-28000440

RESUMEN

Secondary organic aerosol (SOA) is formed from the atmospheric oxidation of gas-phase organic compounds leading to the formation of particle mass. Gasoline- and diesel-powered motor vehicles, both on/off-road, are important sources of SOA precursors. They emit complex mixtures of gas-phase organic compounds that vary in volatility and molecular structure-factors that influence their contributions to urban SOA. However, the relative importance of each vehicle type with respect to SOA formation remains unclear due to conflicting evidence from recent laboratory, field, and modeling studies. Both are likely important, with evolving contributions that vary with location and over short time scales. This review summarizes evidence, research needs, and discrepancies between top-down and bottom-up approaches used to estimate SOA from motor vehicles, focusing on inconsistencies between molecular-level understanding and regional observations. The effect of emission controls (e.g., exhaust aftertreatment technologies, fuel formulation) on SOA precursor emissions needs comprehensive evaluation, especially with international perspective given heterogeneity in regulations and technology penetration. Novel studies are needed to identify and quantify "missing" emissions that appear to contribute substantially to SOA production, especially in gasoline vehicles with the most advanced aftertreatment. Initial evidence suggests catalyzed diesel particulate filters greatly reduce emissions of SOA precursors along with primary aerosol.


Asunto(s)
Gasolina , Emisiones de Vehículos , Aerosoles , Contaminantes Atmosféricos , Vehículos a Motor , Compuestos Orgánicos
18.
Blood Transfus ; 15(3): 191-198, 2017 May.
Artículo en Inglés | MEDLINE | ID: mdl-27483488

RESUMEN

BACKGROUND: In many developed countries hepatitis E virus (HEV) infections have occurred predominantly in travellers to countries endemic for HEV. HEV is a potential threat to blood safety as the virus is transfusion-transmissible. To minimise this risk in Australia, individuals diagnosed with HEV are deferred. Malarialdeferrals, when donors are restricted from donating fresh blood components following travel toanareain which malaria is endemic, probably also decrease the HEV risk, by deferring donors who travel to many countries also endemic for HEV. The aim of this study is to describe overseas-acquired HEV cases in Australia, in order to determine whether infection in travellers poses a risk to Australian blood safety. MATERIALS AND METHODS: Details of all notified HEV cases in Australia from 2002 to 2014 were accessed, and importation rates estimated. Countries in which HEV was acquired were compared to those for which donations are restricted following travel because of a malaria risk. RESULTS: Three hundred and thirty-two cases of HEV were acquired overseas. Travel to India accounted for most of these infections, although the importation rate was highest for Nepal and Bangladesh. Countries for which donations are restricted following travel due to malaria risk accounted for 94% of overseas-acquired HEV cases. DISCUSSION: The vast majority of overseas-acquired HEV infections were in travellers returning from South Asian countries, which are subject to donation-related travel restrictions for malaria. This minimises the risk HEV poses to the Australian blood supply.


Asunto(s)
Enfermedades Transmisibles Importadas/epidemiología , Virus de la Hepatitis E/aislamiento & purificación , Hepatitis E/epidemiología , Adolescente , Adulto , Anciano , Asia/epidemiología , Australia/epidemiología , Donantes de Sangre/provisión & distribución , Seguridad de la Sangre , Femenino , Humanos , Masculino , Persona de Mediana Edad , Viaje , Adulto Joven
19.
J Blood Transfus ; 2016: 3059848, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-27957384

RESUMEN

Dengue viruses (DENV 1-4) are a risk to transfusion safety, with several transfusion-transmitted (TT) cases reported globally. DENV 1-4 are endemic in over 100 countries, with seasonal outbreaks occurring in northeastern Australia. To mitigate TT-DENV risk in Australia, fresh blood components are not manufactured from donors returning from any area (domestic/overseas) with known dengue transmission. Alternatively, TT-DENV risk may be mitigated using an appropriate blood donor screening assay. We aimed to determine the rate of dengue infection in donors during dengue outbreaks in Australia. Plasma samples were collected from blood donors during local dengue outbreaks. All samples were tested for the presence of DENV RNA and selected samples were tested for DENV antigen (nonstructural protein 1, NS1) with two assays. No donors residing in high risk areas had detectable levels of DENV RNA or NS1 and no cases of DENV viremia were detected in blood donors residing in areas of Australia experiencing DENV outbreaks. Definitive conclusions could not be drawn from this study; however, the lack of detection of DENV RNA or antigen in donations suggests that the current risk of TT-DENV is low and maintaining the fresh component restriction for "at-risk" donors is appropriate.

20.
Transfusion ; 56(12): 3086-3093, 2016 12.
Artículo en Inglés | MEDLINE | ID: mdl-27667133

RESUMEN

BACKGROUND: Hepatitis E virus (HEV) poses a risk to transfusion safety. In Australia, locally acquired HEV is rare and cases are mainly reported in travelers returning from countries endemic for HEV. The risk posed by HEV to transfusion safety in Australia is unknown; therefore, we aimed to measure the rate of current HEV infection in Australian blood donations. STUDY DESIGN AND METHODS: A total of 14,799 blood donations were tested for HEV RNA by transcription-mediated amplification, with confirmatory testing by reverse transcription-polymerase chain reaction. Viral load quantification and phylogenetic analysis was performed on HEV RNA-positive samples. RESULTS: One (0.0068%; 95% confidence interval [CI], 0.0002%-0.0376%) sample was confirmed positive for HEV RNA, resulting in a risk of collecting a HEV-viremic donation of 1 in 14,799 (95% CI, 1 in 584,530 to 1 in 2,657). The viral load in this sample was approximately 15,000 IU/mL, and it was determined to be Genotype 3. DISCUSSION: Our finding of 1 in 14,799 Australian donations positive for HEV RNA is lower than that from many other developed countries; this is consistent with the relatively low seroprevalence in Australia. As this HEV RNA-positive sample was Genotype 3, it seems likely that this infection was acquired through zoonotic transmission, either within Australia or overseas in a developed nation. HEV has the potential to pose a risk to transfusion safety in Australia; however, additional, larger studies are required to quantify the magnitude of this risk.


Asunto(s)
Donantes de Sangre , Virus de la Hepatitis E/genética , ARN Viral/sangre , Australia/epidemiología , Seguridad de la Sangre , Hepatitis E/epidemiología , Hepatitis E/transmisión , Humanos , Filogenia , Reacción en Cadena de la Polimerasa , Estudios Seroepidemiológicos , Reacción a la Transfusión , Carga Viral
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