1.
Bioorg Med Chem Lett
; 20(19): 5933-5, 2010 Oct 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20729079
RESUMEN
Substituted-phenoxycarbonylimino neonicotinoid ligands with an electron-donating group showed significantly higher affinity to the insect nicotinic receptor relative to that of the analogue with an electron-withdrawing substituent, thereby establishing in silico binding site interaction model featuring that the phenoxy ring of neonicotinoids and the receptor loop D tryptophan indole plane form a face-to-edge aromatic interaction.