FeS2 nanosheets-luminol-O2 chemiluminescence method for determination of venlafaxine hydrochloride, imipramine hydrochloride, and cefazolin sodium.

This study introduces a novel chemiluminescence (CL) approach utilizing FeS2 nanosheets (NSs) catalyzed luminol-O2 CL reaction for the measurement of three pharmaceuticals, namely venlafaxine hydrochloride (VFX), imipramine hydrochloride (IPM), and cefazolin sodium (CEF). The CL method involved the phenomenon of quenching induced by the pharmaceuticals in the CL reaction. To achieve the most quenching efficacy of the pharmaceuticals in the CL reaction, the concentrations of reactants comprising luminol, NaOH, and FeS2 NSs were optimized accordingly. The calibration curves demonstrated exceptional linearity within the concentration range spanning from 4.00 × 10-7 to 1.00 × 10-3 mol L-1, 1.00 × 10-7 to 1.00 × 10-4 mol L-1, and 4.00 × 10-6 to 2.00 × 10-4 mol L-1 with detection limits (3σ) of 3.54 × 10-7, 1.08 × 10-8, and 2.63 × 10-6 mol L-1 for VFX, IPM, and CEF, respectively. This study synthesized FeS2 NSs using a facile hydrothermal approach, and then the synthesized FeS2 NSs were subjected to a comprehensive characterization using a range of spectroscopic methods. The proposed CL method was effective in measuring the aforementioned pharmaceuticals in pharmaceutical formulations as well as different water samples. The mechanism of the CL system has been elucidated.

FeS2 nanosheets-H2 O2 -NaHCO3 chemiluminescence method for procaine hydrochloride determination.

FeS2 nanosheets (NSs) were produced and exploited as a new catalyst for a chemiluminescence (CL) reaction. The characterization of FeS2 NSs was performed using spectroscopic methods. In this regard, transmission electron microscopy images showed that FeS2 NSs have a length of ~0.5-1 µm. The direct optical band gap energy of FeS2 NSs was found to be 3.45 eV. Prepared FeS2 NSs were used to catalyze the NaHCO3 -H2 O2 CL reaction. It was found that procaine hydrochloride (PCH) could reduce the intensity of the FeS2 NSs-NaHCO3 -H2 O2 CL reaction so, with increasing PCH concentrations, the intensity of light emission decreased. Therefore, a simple and sensitive method was introduced to measure PCH with a linear range expanded from 1.00 × 10-6 to 1.00 × 10-3  mol L-1 and an 8.32 × 10-7  mol L-1 limit of detection. Studies related to the effect of foreign species and reaction mechanisms were performed. The application of the approach was verified by quantifying the PCH in the injection.

Nickel oxide hollow microsphere for the chemiluminescence determination of tuberculostatic drug isoniazid.

In this article, nickel(II) oxide (NiO) hollow microspheres (HMSs) were fabricated and used to catalyze chemiluminescence (CL) reaction. The studied CL reaction is the luminol-oxygen reaction that was used as a sensitive analytical tool for measuring tuberculostatic drug isoniazid (IND) in pharmaceutical formulations and water samples. The CL method was established based on the suppression impact of IND on the CL reaction. The NiO HMSs were produced by a simple hydrothermal method and characterized by several spectroscopic techniques. The result of essential parameters on the analytical performance of the CL method, including concentrations of sodium hydroxide (NaOH), luminol, and NiO HMSs were investigated. At the optimum conditions, the calibration curve for IND was linear in the range of 8.00 × 10-7 to 1.00 × 10-4  mol L-1 (R2  = 0.99). A detection limit (3S) of 2.00 × 10-7  mol L-1 was obtained for this method. The acceptable relative standard deviation (RSD) was obtained for the proposed CL method (2.63%, n = 10) for a 5.00 × 10-6  mol L-1 IND solution. The mechanism of the CL reaction was also discussed.