Squamous-cell carcinoma of the nail bed.

Carcinoma of the nail bed is rare. Two patients with squamous-cell carcinoma are presented. We recommend biopsies for recalcitrant lesions of the nail bed and treatment by amputation or Mohs' surgery if carcinoma is found.

Generalized perforating granuloma annulare: a case report and review of the literature.

A nineteen year old girl with mongolism and generalized perforating granuloma annulare of the lower legs is presented herein. Skin biopsy specimens showed dermal necrobiosis and epidermal perforation. The literature is reviewed and summarized. The lesions have been characterized as small, often umbilicated papules occurring in large numbers on the extremities.

Basal cell epithelioma in a vaccination scar.

A 42-year-old woman developed a superficial basal cell epitheliol in a smallpox vaccination scar. After reviewing similar reports in the English literature, I believe any unusual change occurring in a vaccination scar, either simultaneously or years later, should be viewed as a possible malignancy and treated accordingly.

Inflammatory metastic carcinoma. Carcinoma erysipelatoides.

A patient with pulmonary adenocarcinoma had an erythematous inflammatory lesion resembling erysipelas on the chest wall. Results of a skin biopsy disclosed groups of metastatic adenocarcinoma cells in the dermis, subcutaneous tissue, and lumina of the lymphatic vessels. The diagnosis of the inflammatory metastatic carcinoma should be considered in any persistent and therapeutically unresponsive skin eruption that resembles an infectious process. Careful attention to the clinical features, lack of febrile response, and absence of leukocytosis should assist in making the correct diagnosis of a noninfectious process.

Twenty-nail dystrophy of childhood.

Twenty-nail dystrophy is an idiopathic nail dystrophy that begins insidiously in early childhood. All 20 nails are uniformly affected with excessive longitudinal striations and loss of nail luster. The skin and its ectodermal derivatives are otherwise normal. Twenty-nail dystrophy is believed to be a self-limited abnormality that resolves slowly with age.

Diagnosis of scabies.

Mineral oil scrapings from an infant with a persistent, puzzling, generalized eruption revealed the mite, Sarcoptes scabiei. Various diagnostic technics and treatment for scabies are discussed.