A Fully Automatic Estimation of Tear Meniscus Height Using Artificial Intelligence.

Purpose: Accurate quantification measurement of tear meniscus is vital for the precise diagnosis of dry eye. In current clinical practice, the measurement of tear meniscus height (TMH) relies on doctors' manual operation. This study aims to propose a novel automatic artificial intelligence (AI) system to evaluate TMH. Methods: A total of 510 photographs obtained by the oculus camera were labeled. Three thousand and five hundred images were finally attained by data enhancement to train the neural network model parameters, and 60 were used to evaluate the model performance in segmenting the cornea and tear meniscus region. One hundred images were used to test generalization ability of the model. We modified a segmentation model of the cornea and the tear meniscus based on the UNet-like network. The output of the segmentation model is followed by a calculation module that calculates and reports the TMH. Results: Compared with ground truth (GT) manually labeled by clinicians, our modified model achieved a Dice Similarity Coefficient (DSC) and Intersection over union (Iou) of 0.99/0.98 in the corneal segmentation task and 0.92/0.86 for the detection of tear meniscus on the validation set, respectively. On the test set, the TMH automatically measured by our AI system strongly correlates with the results manually calculated by the ophthalmologists. Conclusions: We developed a fully automated and reliable AI system to obtain TMH. After large-scale clinical testing, our method could be used for dry eye screening in clinical practice.

AES-CSFS: an automatic evaluation system for corneal sodium fluorescein staining based on deep learning.

Background: Corneal fluorescein sodium staining is a valuable diagnostic method for various ocular surface diseases. However, the examination results are highly dependent on the subjective experience of ophthalmologists. Objectives: To develop an artificial intelligence system based on deep learning to provide an accurate quantitative assessment of sodium fluorescein staining score and the size of cornea epithelial patchy defect. Design: A prospective study. Methods: We proposed an artificial intelligence system for automatically evaluating corneal staining scores and accurately measuring patchy corneal epithelial defects based on corneal fluorescein sodium staining images. The design incorporates two segmentation models and a classification model to forecast and assess the stained images. Meanwhile, we compare the evaluation findings from the system with ophthalmologists with varying expertise. Results: For the segmentation task of cornea boundary and cornea epithelial patchy defect area, our proposed method can achieve the performance of dice similarity coefficient (DSC) is 0.98/0.97 and Hausdorff distance (HD) is 3.60/8.39, respectively, when compared with the manually labeled gold standard. This method significantly outperforms the four leading algorithms (Unet, Unet++, Swin-Unet, and TransUnet). For the classification task, our algorithm achieves the best performance in accuracy, recall, and F1-score, which are 91.2%, 78.6%, and 79.2%, respectively. The performance of our developed system exceeds seven different approaches (Inception, ShuffleNet, Xception, EfficientNet_B7, DenseNet, ResNet, and VIT) in classification tasks. In addition, three ophthalmologists were selected to rate corneal staining images. The results showed that the performance of our artificial intelligence system significantly outperformed the junior doctors. Conclusion: The system offers a promising automated assessment method for corneal fluorescein staining, decreasing incorrect evaluations caused by ophthalmologists' subjective variance and limited knowledge.

Illumination-Invariant Flotation Froth Color Measuring via Wasserstein Distance-Based CycleGAN With Structure-Preserving Constraint.

Froth color can be referred to as a direct and instant indicator to the key flotation production index, for example, concentrate grade. However, it is intractable to measure the froth color robustly due to the adverse interference of time-varying and uncontrollable multisource illuminations in the flotation process monitoring. In this article, we proposed an illumination-invariant froth color measuring method by solving a structure-preserved image-to-image color translation task via an introduced Wasserstein distance-based structure-preserving CycleGAN, called WDSPCGAN. WDSPCGAN is comprised of two generative adversarial networks (GANs), which have their own discriminators but share two generators, using an improved U-net-like full convolution network to conduct the spatial structure-preserved color translation. By an adversarial game training of the two GANs, WDSPCGAN can map the color domain of froth images under any illumination to that of the referencing illumination, while maintaining the structure and texture invariance. The proposed method is validated on two public benchmark color constancy datasets and applied to an industrial bauxite flotation process. The experimental results show that WDSPCGAN can achieve illumination-invariant color features of froth images under various unknown lighting conditions while keeping their structures and textures unchanged. In addition, WDSPCGAN can be updated online to ensure its adaptability to any operational conditions. Hence, it has the potential for being popularized to the online monitoring of the flotation concentrate grade.

Toward Flotation Process Operation-State Identification via Statistical Modeling of Biologically Inspired Gabor Filtering Responses.

This paper presents a froth image statistical modeling-based online flotation process operation-state identification method by introducing a biologically inspired Gabor wavelet transform in accordance with the physiological findings in the biological vision system. It derived the latent probabilistic density models of these biologically inspired Gabor filtering responses (GFRs) based on a versatile intermediate probability modeling frame, Gaussian scale mixture model. It has demonstrated that both the real and the imaginary representation of GFR obey a Laplace distribution. Accordingly, the amplitude representation of GFR obeys a Gamma distribution. Whereas the phase representation of GFR is an important yet frequently ignored aspect in Gabor-based signal analysis; it is demonstrated to be a periodic distribution and can be expressed by a von Mises-like distribution model. Successively, a local spline regression (LSR)-based classifier that the maps scattered statistical feature points of froth images directly to the operation-state labels smoothly is introduced for the operation-state recognition. Extensive confirmatory and comparative experiments on an industrial-scale bauxite flotation process demonstrate the effectiveness and superiority of the proposed method. Performance effects on different parameter settings, e.g., parameters of Gabor kernel and dimensionalities of multivariate statistical models, are further discussed.