Transcription factor DIVARICATA1 positively modulates seed germination in response to salinity stress.

Seed germination is a critical checkpoint for plant growth under unfavorable environmental conditions. In Arabidopsis (Arabidopsis thaliana), the abscisic acid (ABA) and gibberellic acid (GA) signaling pathways play important roles in modulating seed germination. However, the molecular links between salinity stress and ABA/GA signaling are not well understood. Herein, we showed that the expression of DIVARICATA1 (DIV1), which encodes a MYB-like transcription factor, was induced by GA and repressed by ABA, salinity, and osmotic stress in germinating seeds. DIV1 positively regulated seed germination in response to salinity stress by directly regulating the expression of DELAY OF GERMINATION 1-LIKE 3 (DOGL3) and GA-STIMULATED ARABIDOPSIS 4 (GASA4) and indirectly regulating the expression of several germination-associated genes. Moreover, NUCLEAR FACTOR-YC9 (NF-YC9) directly repressed the expression of DIV1 in germinating seeds in response to salinity stress. These results help reveal the function of the NF-YC9-DIV1 module and provide insights into the regulation of ABA and GA signaling in response to salinity stress during seed germination in Arabidopsis.

Healthcare professionals' perspectives on the challenges with managing polycystic ovary syndrome: A systematic review and meta-synthesis.

OBJECTIVE: To provide an overview of healthcare professionals' experience of PCOS management and identify the relevant facilitators and barriers. METHODS: A systematic search was conducted in MEDLINE, EMBASE, CINAHL, Web of Science, and Cochrane CENTRAL database from the earliest available date to April 2023. Qualitative and mixed methods studies that described healthcare professionals' experiences of PCOS management were included. RESULTS: A total of 74 findings were extracted from the 8 included studies, which were categorized into facilitators and barriers. The barriers were meta-aggregated into four themes: the weakness of clinical evidence; women's low adherence to PCOS management; various obstacles that healthcare professionals face, and the influence of social environment and culture. The facilitators were meta-aggregated into three themes: chronic disease healthcare plan, communication techniques and healthcare professionals' ability and awareness. CONCLUSION: The findings of this study have the potential to improve the care provided to women with PCOS. However, it is important for national health professionals and policy markers to consider the cultural context of their own country when implementing these findings. PRACTICAL IMPLICATIONS: This study illustrated several challenges in managing the heterogeneous condition of PCOS and provide insights for the development of medical policies and future research directions.

Factors associated with discontinuation in fertility treatment: a systematic scoping review.

PURPOSE: The discontinuation of fertility treatment could decrease the chances of achieving parenthood for infertile patients and often leads to economic loss and medical resource waste. However, the evidence on the factors associated with discontinuation is unclear and inconsistent in the context of fertility treatment. This scoping review aimed to summarize the evidence on factors associated with discontinuation in fertility treatment, identify the current knowledge gap, and generate recommendations for future research. METHODS: We searched PubMed, Embase, The Cochrane Library, Web of Science, CINAHL, American Psychological Association, and http://clinicaltrials.gov from inception to June 2023 without language or time restrictions. We also searched the grey literature in Open Grey and Google Scholar and hand-searched the reference lists of relevant studies to identify potentially eligible studies. Publications that studied factors associated with discontinuation in fertility treatment were included. The identified factors were mapped to the World Health Organization's treatment adherence model. RESULTS: Thirty-seven articles involving 41,973 infertile patients from 13 countries were included in this scoping review. All studies identified the factors from the perspective of patients, except for one that described the factors from the healthcare providers' perspective. A total of 42 factors were identified, with most of them belonging to the patient-related dimension, followed by socio-economic-related, treatment-related, condition-related, and healthcare system-related dimensions. Female education level, social support, and insurance coverage decreased the likelihood of treatment discontinuation, whereas multiparous women, male infertility, depression, higher infertility duration, and treatment duration increased the likelihood of treatment discontinuation. Age, education level, and ethnicity are the commonly nonmodifiable factors for treatment discontinuation, while insurance coverage, depression, and anxiety symptoms are among some of the more commonly reported modifiable factors. CONCLUSION: This is the first scoping review examining and synthesizing evidence on the factors influencing of discontinuation in fertility treatment. This review could inform researchers, clinicians, and policymakers to address modifiable barriers and facilitators to develop personalized and multicomponent interventions that could improve the discontinuation in fertility treatment.

Logical Magic State Preparation with Fidelity beyond the Distillation Threshold on a Superconducting Quantum Processor.

Fault-tolerant quantum computing based on surface code has emerged as an attractive candidate for practical large-scale quantum computers to achieve robust noise resistance. To achieve universality, magic states preparation is a commonly approach for introducing non-Clifford gates. Here, we present a hardware-efficient and scalable protocol for arbitrary logical state preparation for the rotated surface code, and further experimentally implement it on the Zuchongzhi 2.1 superconducting quantum processor. An average of 0.8983±0.0002 logical fidelity at different logical states with distance three is achieved, taking into account both state preparation and measurement errors. In particular, the logical magic states |A^{π/4}⟩_{L}, |H⟩_{L}, and |T⟩_{L} are prepared nondestructively with logical fidelities of 0.8771±0.0009, 0.9090±0.0009, and 0.8890±0.0010, respectively, which are higher than the state distillation protocol threshold, 0.859 (for H-type magic state) and 0.827 (for T-type magic state). Our work provides a viable and efficient avenue for generating high-fidelity raw logical magic states, which is essential for realizing non-Clifford logical gates in the surface code.

Application of multiplex PCR capillary electrophoresis and analysis of distribution characteristics of HPV infection subtypes / 中华预防医学杂志

Objective: To analyze the characteristics of human papillomavirus (HPV) infection and the distribution of HPV subtypes in Shijiazhuang, Hebei Province, and to explore the application evaluation of multiple PCR capillary electrophoresis fragment analysis for HPV typing test. Methods: A population-based cross-sectional study was conducted among 434 women (age range 17 to 74 years old, 260 patients and 174 physical examinations) included from May to August 2022 in Hebei General Hospital. HPV typing was detected by multiple PCR-capillary electrophoresis fragment analysis. Using the multiple fluorescence quantitative PCR kit as a reference, Chi-square test was used to analyze the diagnostic effect of multiple PCR-capillary electrophoresis fragment analysis, and the consistency was analyzed by Kappa value. Results: The total HPV infection rate was 45.85%(199/434), including 35.48% (154/434) of high-risk HPV (HR-HPV), 3.92% (17/434) of low-risk HPV (LR-HPV), 6.45% (28/434) of HR-HPV and LR-HPV mixed infection, 27.88% (121/434) of single type HPV and 17.97% (78/434) of multi type HPV. HPV52 (9.68%, 42/434), HPV16 (6.91%, 30/434), and HPV58 (6.91%, 30/434) are common HPV subtypes. The positive rate of physical examination was 45.40% (79/174), which was slightly lower than that of patients 46.15% (120/260), there was no significant difference (χ2=0.024,P>0.05). The highest infection rate in the 17-30 age group was 54.76% (46/84), and there was no statistical difference among the age groups(χ2=4.123,P>0.05). The sensitivity and specificity of multiplex PCR capillary electrophoresis fragment analysis were 92.96% and 94.04%, respectively, and Kappa value was 0.870, with the multiplex fluorescent quantitative PCR as the reference. Conclusion: HPV infection may appear younger, and the positive rate of HR-HPV infection is the highest, with HPV52, 16, 58 as the main infection subtypes. The detection results of multiplex PCR capillary electrophoresis fragment analysis method are highly consistent with those of multiplex fluorescent quantitative PCR method, which is suitable for HPV DNA typing.

Polymeric photothermal nanoplatform with the inhibition of aquaporin 3 for anti-metastasis therapy of breast cancer.

Metastasis, as one of major challenges in the cancer treatment, is responsible for the high mortality of breast cancer. It has been reported that breast cancer cell invasion and metastasis are related to aquaporin 3 (AQP3), which is the transmembrane transport channel for H2O2 molecules. Moreover, there is agreement that preventing the metastasis of breast tumor cells in combination with inhibiting the tumor growth is a promising strategy for cancer chemotherapy. Herein, we constructed a flexible photothermal crosslinked polymeric nanovehicle for the delivery of the AQP3 inhibitor, [AuCl2(phen)]+Cl- (Auphen). The polymeric nanovehicle (pOMPC-Dex) is comprised of three modules: 1) pOEGMA-co-pMEO2MA serves as the temperature-responsive segment; 2) pCyanineMA acts as the near-infrared (NIR) optical absorbing motif for photothermal therapy and is conjugated with pOEGMA-co-pMEO2MA to obtain NIR light stimuli-responsive drug release; and 3) pPBAMA-Dex functions as an acidic tumor microenvironment-responsive unit. Auphen was encapsulated into a nanovehicle (Auphen@pOMPC-Dex) through electrostatic interactions. The designed nanoplatform showed a pH- and NIR light stimuli-responsive drug release profile and exhibited the strong inhibition of intracellular H2O2 uptake by breast cancer cells, which led to the inhibition of breast cancer cell migration and invasion in vitro. In a breast cancer mouse model, Auphen@pOMPC-Dex markedly reduced the number of lung metastases in tumor-bearing mice due to the combined suppression of tumor growth and metastasis. Consequently, the fabricated Auphen@pOMPC-Dex may provide a new strategy for the development of comprehensive oncotherapies. STATEMENT OF SIGNIFICANCE: High mortality due to metastasis-induced breast cancer has been a key issue that needs to be addressed. It has been reported that aquaporin 3 (AQP3), a transmembrane transport channel for H2O2 molecules was found to have an accelerated effect on breast cancer cell migration. Hence, a flexible crosslinked polymeric nanoplatform with the inhibition of AQP3 was designed to inhibit metastasis of breast cancer cells. At the same time, we combined suppression of tumor growth with photothermal therapy to enhance the anticancer therapy effect.

Dynamics of Rising Bubbles and Their Impact with Viscoelastic Fluid Interfaces.

Bubble dynamics plays a significant role in a wide range of industrial fields, such as food, pharmacy and chemical engineering. The physicochemical properties of complex fluids can greatly affect the speed with which bubbles rise, and the lifetime of bubbles, which in turn can affect the efficiency of food and drug manufacturing and also sewage purification. Therefore, it is of great scientific and practical significance to study the influence mechanism of nanoparticles and surfactants on bubble rising and impact in a complex fluid interface. This paper selects a mixed dispersion liquid of nanoparticles (SiO2) and a surfactant (SDS) as the objects of the study, observes in real-time the entire processes of bubbles rising, impact at the gas-liquid interface, and rupture, and analyzes the dynamic mechanism of bubble impact in a complex fluid interface. By analyzing the morphological changes of the rising bubbles, the rising velocity and the lifetime of the bubbles, it is found that the surfactant molecules are distributed in the ultrapure water liquid pool and the liquid film surrounding the bubbles. Such distribution can reduce the viscoelasticity between bubbles and the liquid surface, and lower the surface tension of the liquid, which can reduce the rising velocity of bubbles, delay the drainage process of bubbles on a liquid surface, and enhance the lifetime of bubbles. If the liquid surface is covered with nanoparticles, a reticulate structure will be formed on the bubble liquid film, which can inhibit bubble discharge and prolong bubble lifetime. In addition, the influence of such a reticulate structure on liquid surface tension is limited and its function is far smaller than a surfactant.

Realization of an Error-Correcting Surface Code with Superconducting Qubits.

Quantum error correction is a critical technique for transitioning from noisy intermediate-scale quantum devices to fully fledged quantum computers. The surface code, which has a high threshold error rate, is the leading quantum error correction code for two-dimensional grid architecture. So far, the repeated error correction capability of the surface code has not been realized experimentally. Here, we experimentally implement an error-correcting surface code, the distance-three surface code which consists of 17 qubits, on the Zuchongzhi 2.1 superconducting quantum processor. By executing several consecutive error correction cycles, the logical error can be significantly reduced after applying corrections, achieving the repeated error correction of surface code for the first time. This experiment represents a fully functional instance of an error-correcting surface code, providing a key step on the path towards scalable fault-tolerant quantum computing.

A Biomimetic Nonantibiotic Nanoplatform for Low-Temperature Photothermal Treatment of Urinary Tract Infections Caused by Uropathogenic Escherichia coli.

Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) remain a matter of concern, as the clinical use of multiple antibiotics induces antibiotic resistance in bacteria, resulting in the failure of treatments. Despite the emergence of anti-adhesion strategies that can prevent the development of bacterial drug resistance, these strategies are mainly used for disease prevention rather than effective treatment. Photothermal therapy (PTT) has emerged as an efficient alternative for the elimination of bacteria. Nevertheless, high local temperatures related to PTT probably cause damage to surrounding healthy tissue. Herein, a biomimetic nonantibiotic nanoplatform for low-temperature photothermal treatment of UTIs is developed. The nanoplatform comprises polydopamine (PDA) photothermal core and biphenyl mannoside (Man) shell with multivalent high-affinity to UPEC. Scanning electron microscope (SEM) shows PDA-Man possessed ultra-strong targeting binding ability toward UPEC. It is the fact that this impulse UPEC to form a large bacterial cluster. Consequently, the high photothermal energy of the PDA-Man appears predominantly in the affected bacterial area, while the overall environment remains at a low temperature. The fabricated nanoplatform shows excellent photothermal bactericidal effects, approximately 100% in a UTI model. Overall, this low-temperature photothermal nanoplatform provides an appropriate strategy for the elimination of bacteria in clinical applications.

Fiber bundle-based chemiluminescence array detection.

Chemiluminescence (CL) is a dominant technology in clinical diagnosis. In order to meet the increasing demand for the sensitive and simultaneous detection of chemiluminescence from multiple samples, the development of multiplex analysis on a single chip is highly desired. However, most chemiluminescence detection systems for multiple samples are still simple lens-based optical imaging systems, and a compromise must always be made between a large aperture (required by the weak chemiluminescence) and a large field of view (required by the size of the sample array). In this paper, we report a fiber bundle-based chemiluminescence detection system for the simultaneous and efficient detection of multiple chemiluminescent samples. In this system, one side of the fiber bundle is directly coupled to the optically active surface of a charge-coupled device (CCD), while the other end is divided into many sub-bundles that are aligned above the samples in a chemiluminescence array to collect their chemiluminescence. Taking advantage of the large numerical aperture and high transmittance of optical fibers, this system shows about a 50 times increase in chemiluminescence collection efficiency over the lens-based imaging system. Moreover, it shows no vignetting effect that is inevitable in a lens-based imaging system with a large field of view. This work provides a promising method for multiple sample chemiluminescence detection, and should find application in bioassays.

Regulatory Mechanisms of Environmental Molecular Signaling in the Tangential Migration of Cortical Interneurons / 中国生物化学与分子生物学报

Brain activity requires the regulation of excitatory and inhibitory neurons. GABAergic interneurons are considered to prevent hyperexcitability in brain. Severe GABAergic deficits have been proved to cause pathological hyperexcitability. Most cortical interneurons originate from the ventral telencephalon and then undergo a long tangential migration to the cortex, followed by radial migration into developing cortical plate. Among them, tangential migration is considered to be the main migration manner of interneurons. The process is rather complex but also precise. With the deepening research on the tangential migration of cortical neurons, many molecules have been proved to play important roles in the process of migration. In this review, we mainly describe the migration path and migration manner of interneurons, and its underlying mechanism in two aspects. On the one hand, neurotrophins such as BDNF, NT-4, GDNF, HGF and neurotransmitters such as GABA, Glu, DA can enhance the motility of interneurons. On the other hand, several protein families as well as proteoglycans, such as Ephrin, Sema and Nrg, can bind to membrane-bound or secreted guidance cues of interneurons, providing direction clues for neuronal migration. In this review, we discussed the tangential migration of interneurons in mice, in order to provide novel insights into the regulatory molecular mechanisms of cerebral cortical development and help to develop new targets against defects in neural developments.

Rapid Internal Control Reference Recombinase-Aided Amplification Assays for EBV and CMV Detection / 生物医学与环境科学（英文）

Epstein-Barr virus (EBV) and cytomegalovirus (CMV), two of the most prevalent human herpesviruses, cause a wide spectrum of diseases and symptoms and are associated with serious health problem. In this study, we developed an internal control reference recombinase-aided amplification (ICR-RAA) assay for the rapid detection of EBV and CMV within 30 min. The assay had a sensitivity of 5 and 1 copies/test for EBV and CMV, respectively, with no cross reaction with other pathogens. In comparison with those of the commercial quantitative polymerase chain reaction (qPCR), the sensitivity of the EBV and CMV ICR-RAAs using extracted DNA was 93.33% and 84.84%, respectively; the specificity was 98.75% and 100.00%, respectively; and the Kappa values were 0.930 and 0.892 (

Advances in inorganic nanomaterials regulated autophagy in cancer treatment / 医学研究生学报

Autophagy represents one of the essential cellular mechanism to maintain homeostasis within cells, performing multiple biological functions during tumorigenesis. Base on the unique physicochemical properties of inorganic nanomaterials, supplemented by easy modification and targeting and so on, they could be used to regulate autophagy, controlling the occurrence and development of tumor and finally achieve treatment. This article primarily reviews the application of several representative inorganic nanomaterials, such as Gold nanoparticles, Silver nanoparticles, Iron oxide nanoparticles, Fullerene C60 nanomaterials, Graphene oxide nanomaterials in regulating autophagy of tumor cells and achieving treatment in recent years.

MYCT1 represses apoptosis of laryngeal cancerous cells through the MAX/miR-181a/NPM1 pathway.

MYCT1 is an important gene known to regulate cell viability and apoptosis of laryngeal cancer cells. However, the underlying molecular mechanism remains unclear. Here, we show that MAX enhances the expression of miR-181a by directly binding to its promoter, whereas miR-181a targets NPM1 and suppresses its expression in laryngeal cancer cells. MYCT1 and miR-181a decrease cell viability and colony formation through enhanced apoptosis, whereas NPM1 displays opposite effects in laryngeal cancer cells. Their opposing functions are further supported by the findings (a) that miR-181a is down-regulated, while NPM1 is up-regulated in laryngeal cancer, and (b) that either inhibition of miR-181a or overexpression of NPM1 can revert the pro-apoptotic effects of MYCT1 on laryngeal cancer cells through extracellular and intracellular apoptotic pathways. Our data suggest that MYCT1 may synergistically interact with MAX as a co-transcription factor or a component of MAX transcriptional complex, to transcriptionally regulate the expression of miR-181a, which, in turn, decreases NPM1 expression at post-transcriptional levels, leading to enhanced apoptosis in laryngeal cancer cells. These factors may serve as potential targets for early diagnosis and treatment of laryngeal cancer.

Biological characteristics of human bone marrow mesenchymal stem cells in the microenvironment of rabbit bladder acellular matrix graft / 西安交通大学学报(医学版)

Objective: To explore the effects of the microenvironment of rabbit bladder acellular matrix graft (BAMG) on proliferation, cell surface markers, and molecular protein level of human bone marrow mesenchymal stem cells (hBMSCs). Methods: We prepared BAMG immersion fluid medium and detected its effect on the proliferation of hBMSCs by MTT method. The expressions of CD44, CD45, CD73 and PDGFRβ were detected by flow cytometry. The expressions of PPAR, OCN and α-SMA were detected by RT-PCR, and the expression of OCT was detected by Western blot. Results: hBMSCs had good compatibility with BAMG. The MTT method showed that BAMG and BAMG immersion medium did not affect the proliferation capacity of hBMSCs. The surface of hBMSCs cells cultured with immersion fluid still expressed CD44, CD73 and PDGFRβ, but not CD45. RT-PCR showed that OCN, PPAR, and α-SMA were all expressed. Western blot test also showed the positive expression of OCT-4. Conclusion: hBMSCs can still keep their original biological characteristics in the microenvironment of rabbit BAMG. It can be the seed cells and combined substrate materials for urinary system tissue engineering.

Associations of TGFBR1 and TGFBR2 gene polymorphisms with the risk of hypospadias: a case-control study in a Chinese population.

This case-control study investigated the association of transforming growth factor-ß (TGF-ß) receptor type I and II (TGFBR1 and TGFBR2) gene polymorphisms with the risk of hypospadias in a Chinese population. One hundred and sixty two patients suffering from hypospadias were enrolled as case group and 165 children who underwent circumcision were recruited as control group. Single nucleotide polymorphisms (SNPs) in TGFBR1 and TGFBR2 genes were selected on the basis of genetic data obtained from HapMap. PCR-restriction fragment length polymorphism (PCR-RFLP) was performed to identify TGFBR1 and TGFBR2 gene polymorphisms and analyze genotype distribution and allele frequency. Logistic regression analysis was conducted to estimate the risk factors for hypospadias. No significant difference was found concerning the genotype and allele frequencies of TGFBR1 rs4743325 polymorphism between the case and control groups. However, genotype and allele frequencies of TGFBR2 rs6785358 in the case group were significantly different in contrast with those in the control group. Patients carrying the G allele of TGFBR2 rs6785358 polymorphism exhibited a higher risk of hypospadias compared with the patients carrying the A allele (P<0.05). The TGFBR2 rs6785358 genotype was found to be significantly related to abnormal pregnancy and preterm birth (both P<0.05). The frequency of TGFBR2 rs6785358 GG genotype exhibited significant differences amongst patients suffering from four different pathological types of hypospadias. Logistic regression analysis revealed that preterm birth, abnormal pregnancy, and TGFBR2 rs6785358 were the independent risk factors for hypospadias. Our study provides evidence that TGFBR2 rs6785358 polymorphism might be associated with the risk of hypospadias.

Preparation of silkworm pupa polysaccharide capsules / 中成药

AIM To prepare the silkworm pupa polysaccharide capsules.METHODS The crude silkworm pupa polysaccharide was extracted by alkali-assisted ultrasonic wave.After deproteinization and decolorization,it was dialysed,and then isolated and purified by SephadexG-150 column.Single factor test was applied to optimizing three influencing factors including ethanol concentration,soild-liquid ratio and drying temperature.The polysaccharide powder's angle of repose,bulk density and critical relative humidity were determined,after which the water content,load difference and disintegration time of obtained capsules were investigated.RESULTS The optimal conditions were determined to be 90％ for ethanol concentration,1 ∶ 1 for soild-liquid ratio,and 60 ℃ for drying temperature.For polysaccharide powder,the average angle of repose was 37.74℃,the average bulk density was 0.51 g/mL,and the critical relative humidity was 63％.With 6.87％ for water content,0.132 3 g for average load,and 12.12 min for average disintegration time,the capsules were qualified according to standard requirements of Chinese Pharmacopoeia.CONCLUSION The good formability of silkworm pupa polysaccharide capsules demonstrates that this simple,stable and controllable technology can provide an experimental basis for the development of related drugs.

Non-contact physiological signal detection using continuous wave Doppler radar.

The aim of this work is to show non-contact physiological signal monitoring system based on continuous-wave (CW) Doppler radar, which is becoming highly attractive in the field of health care monitoring of elderly people. Two radar signal processing methods were introduced in this paper: one to extract respiration and heart rates of a single person and the other to separate mixed respiration signals. To verify the validity of the methods, physiological signal is obtained from stationary human subjects using a CW Doppler radar unit. The sensor operating at 24 GHz is located 0.5 meter away from the subject. The simulation results show that the respiration and heart rates are clearly extracted, and the mixed respiration signals are successfully separated. Finally, reference respiration and heart rate signals are measured by an ECG monitor and compared with the results tracked by the CW Doppler radar monitoring system.

Status and changes of soil nutrients in rhizosphere of Abelmoschus manihot different planting age / 中国中药杂志

Using soil chemical analysis method and combining with ICP-AES determination of mineral nutrition element content in rhizosphere soil of different planting age Abelmoschus Corolla Results show that along with the increase of planting age, the nitrogen (total N), available P and organic matter in rhizosphere soil of Abelmoschus Corolla content declined year by year and the soil got acidification. Heavy metal element content in agricultural land does not exceed national standards, but the content of element mercury (Hg) in rhizosphere soil of different planting age Abelmoschus Corolla declined. Request of microelement such as manganese (Mn) and zinc (Zn) had a increase tendency, but the content of magnesium (Mg) and sodium (Na) increased, and other nutrient elements had no changed rules or unchanged apparently. Consequently, exploring the change rules of different planting age Abelmoschus Corolla soil in rhizosphere as theoretical guidance of rational fertilization and subducting continuous cropping obstscles.

[Effects of hydroxyapatite on growth and quality of potato (Solanum tuberosum L.) in Cd polluted soil].

A pot experiment was conducted in a glasshouse to study effects of hydroxyapatite amending Cd polluted soil on growth and quality of potato (Solanum tuberosum L.). In the experiment, 3 levels of Cd pollution (0, 5, and 10 mg x kg(-1)) and 6 levels of hydroxyapatite application (0, 4, 8, 10, 16, and 30 g x kg(-1)) in soil were prepared to plant 2 potato varieties (Zhongshusanhao and Daxiyang in Chinese system). The results showed that Cd pollution in soil resulted in decrease in yield per plant of potato; for example, in the soils with 5 and 10 mg x kg(-1) of Cd, the yield per plant decreased 24%-31% and 41%-45%, respectively. Applying hydroxyapatite to Cd pollution could greatly increase yield per plant of potato. Compared to the soil without hydroxyapatite, 10 or 30 g x kg(-1) hydroxyapatite added to the soil with 5 or 10 mg x kg(-1) of Cd increased 17%-9% or 45%-58% in yield per plant. Due to hydroxyapatite amending Cd polluted soil, chlorophyll contents in leaves and superoxide dismutase (SOD) activities in tubers enhanced and malondialdehyde (MDA) contents in tubers declined apparently. Meanwhile, quality of potato tubers was obviously improved, such as increase in vitamin C contents, starch contents, and protein contents in potato tubers. With hydroxyapatite applying from 0 to 30 g x kg(-1), Cd contents in potato tubers deceased from 0.87-0.95 mg x kg(-1) to 0.13-0.21 mg x kg(-1) by 78%-85% in the soils with 5 mg x kg(-1) of Cd, and from 1.86-1.93 mg x kg(-1) to 0.52-0.65 mg x kg(-1) by 66%-72% in the soils with 10 mg x kg(-1) of Cd. The experiment indicated that the mechanism of hydroxyapatite alleviating soil Cd toxicity main included rising soil pH values, reducing effective Cd contents in soil, and Ca from hydroxyapatite blocking soil Cd moving to potato. However, ability of hydroxyapatite alleviating soil Cd toxicity was limited, and excessive hydroxyapatite to soil exhibited stress effects on growth and quality of potato. In the Cd polluted soils with proper hydroxyapatite, growth and quality of Zhongshusanhao were better than those of Daxiyang, indicating different responses of various potato varieties to environment amelioration.