Preparation and Application of High-Efficiency, Antibacterial, and Antiviral PET-PTHP Fibers.

Transmission through the respiratory tract is one of the most important ways for bacteria and viruses to infect the human body; the use of high-performance antibacterial and antiviral protective equipment is the most effective way to prevent the spread of respiratory diseases. However, at present, most personal protective equipment lacks the ability to kill pathogens. In this paper, a kind of polytetrahydropyrimidine-polyethylene terephthalate functional fiber (PET-PTHP fibers) with highly sustained antibacterial and antiviral properties was prepared. The inactivation rate of the fibers against Staphylococcus aureus and Escherichia coli was as high as 99.99%, and the antibacterial time was more than 72 h. The fibers have an obvious destructive effect on lentiviruses and can reduce the infection rate of lentiviruses in BxPC-3 cells from 25.4 to 9.7%. The cytotoxicity test, cell live/dead staining test, and cell proliferation test all confirmed that PET-PTHP fibers have no obvious cytotoxicity and good cytocompatibility. By applying the functional fibers to the inner layer of the masks, a new type of mask with adsorption, filtration, and killing properties against pathogens was prepared. The filtration efficiency of the new masks was 99.3%, and the pressure drop was 104 Pa. The new masks have excellent air permeability and filtration effect, meet the practical application conditions, and are of grade A; therefore, these masks provide medical protection as well as kill pathogens at the same time, further reducing the risk of human infection.

Preparation and application of urea-based derivatized ß-cyclodextrin chiral stationary phase based on diazotized silica microspheres.

Recently, the design and development of efficient chiral stationary phases is still the core and goal of chiral chromatography. In order to quickly separate chiral drugs, we designed and prepared an environmentally friendly small particle chiral stationary phase: p-methylphenylurea-ß-cyclodextrin chiral stationary phase (SiO2@PMPU-ß-CD). Firstly, p-methylphenylurea-ß-cyclodextrin (PMPU-ß-CD) was connected to the surface of mesoporous silica microspheres by diazoresin (DR) to prepare a SiO2@PMPU-ß-CD. In reverse elution mode, the column temperature was set at 25 °C, the flow rate was 0.2 mL/min, and ACNH2O (v/v = 70:30) was used as the elution condition of the mobile phase. The enantiomers of chlorpheniramine maleate, 2-phenylcyclohexanone, and promethazine were separated within 5 min. In addition, the addition of TEAA buffer to the mobile phase improved the enantiomer resolution of chlorpheniramine maleate from 1.03 to 5.69. The experimental results show that the SiO2@PMPU-ß-CD column can be used for the separation of appellant chiral drugs with good repeatability, and the use of DR instead of silane coupling agent has the advantages of being non-toxic, environmentally protected, and easy to operate, which is of great significance for the development of chiral stationary phase.