RESUMEN
A new abietane diterpenoid, 1ß, 11-epoxyabieta-12-hydroxy-8, 11, 13-triene-7-one (1), along with three known compounds (2-4), was isolated from Lycopodium complanatum. Their structures were confirmed by the analysis of 1D, 2D NMR and HRESIMS data, and comparison with previous spectral data. All compounds were tested for inhibitory activities against A549, HepG2 and MCF-7 tumor cell lines. [Figure: see text].
Asunto(s)
Antineoplásicos Fitogénicos , Lycopodium , Humanos , Abietanos/farmacología , Abietanos/química , Estructura Molecular , Lycopodium/química , Línea Celular Tumoral , Células MCF-7 , Antineoplásicos Fitogénicos/farmacología , Antineoplásicos Fitogénicos/químicaRESUMEN
Two new C21 steroidal glycosides, brapreguanes A and B (1-2) were isolated from 75 % aqueous ethanol extract of Selaginella braunii Baker. Their structures were established by spectroscopic analyses (1D/2D NMR spectra and HR-ESI-MS). The absolute configurations of sugar were elucidated by enzymatic hydrolysis and GCMS analysis. In addition, all compounds were evaluated for the anti-proliferative activities against various human cancer cells inâ vitro. Compounds exhibited no inhibition to various human cancer cells.
Asunto(s)
Selaginellaceae , Humanos , Selaginellaceae/química , Estructura Molecular , Glicósidos/farmacología , Glicósidos/química , Azúcares , Etanol , Extractos VegetalesRESUMEN
Four new prenylflavonol glycosides (1-4) along with two known analogues (5-6) were isolated from the leaves of Cyclocarya paliurus for the first time. The structures of these compounds were characterized by comprehensive analysis of 1 D, 2 D NMR, HRESIMS, UV data and enzymatic hydrolysis. In bioassays, compounds 1-4 were evaluated for inhibitory effects on xanthine oxidase (XOD) and effects on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS) induced RAW264.7 cells. Moreover, compounds 1 and 2 showed outstanding XOD inhibitions with IC50 values of 18.16 ± 3.91 and 37.65 ± 5.67 µM, and exhibited inhibitions against LPS-induced NO production with IC50 values of 80.50 ± 3.09 and 82.28 ± 2.87 µM.
Asunto(s)
Juglandaceae , Triterpenos , Glicósidos/farmacología , Hojas de la Planta , Xantina OxidasaRESUMEN
Three previously undescribed seco-dammarane triterpenoid glycosides O-Q (1-3) along with two known compounds (4 and 5) were isolated and characterized from the leaves of Cyclocarya paliurus. Their structures were determined by comprehensive analysis of 1 D, 2 D NMR and HRESIMS data. Compounds 1-5 were evaluated for their inhibitory effects against human pancreatic tumor (ASPC-1), human gastric carcinoma (SNU5), liver hepatocellular carcinoma (HEPG-2) and human colon tumor (HCT116) cell lines. Among them cyclocarioside P (2) showed somewhat inhibitory activity towards those tumor cells.
Asunto(s)
Antineoplásicos Fitogénicos/farmacología , Juglandaceae/química , Triterpenos/química , Triterpenos/farmacología , Antineoplásicos Fitogénicos/química , Línea Celular Tumoral , Ensayos de Selección de Medicamentos Antitumorales , Glicósidos/química , Células HCT116 , Células Hep G2 , Humanos , Espectroscopía de Resonancia Magnética , Estructura Molecular , Neoplasias Pancreáticas/tratamiento farmacológico , Neoplasias Pancreáticas/patología , Hojas de la Planta/química , DamaranosRESUMEN
Eight new prenylflavonol glycosides (1-8), along with five known analogues (9-13) were isolated from the n-butanol extract of the dried leaves of Cyclocarya paliurus (family Juglandaceae) for the first time. The structures of these compounds were characterized by comprehensive analysis of 1D, 2D NMR, HRESIMS, UV data and acid hydrolysis. In bioassay, all these thirteen prenylflavonol glycosides exhibited inhibitory effects on xanthine oxidase (XOD) activity. Especially compounds 2 and 7, showed outstanding IC50 values of 31.81 ± 2.20 and 29.71 ± 3.69 µM, respectively.
Asunto(s)
Inhibidores Enzimáticos/farmacología , Flavonoles/farmacología , Glicósidos/farmacología , Juglandaceae/química , Hojas de la Planta/química , Xantina Oxidasa/antagonistas & inhibidores , Extractos Vegetales/química , Análisis Espectral/métodos , Relación Estructura-ActividadRESUMEN
Hericium erinaceus is a well-known medicinal and edible mushroom, which is considered as a potential source to obtain antitumor candidates. In this work, five new isoindolinones, named erinaceolactams A-E (1-5), along with five known compounds (6-10), were isolated from 70% ethanol extract of the fruiting bodies of H. erinaceus. The structures of new compounds were validated by HRESIMS and 1D, 2D NMR. It's worth mentioning that there are two pairs of isomers included in the new compounds. Moreover, their cytotoxicity against metastatic human hepatocellular carcinoma cell lines SMMC-7221 and MHCC-97H were evaluated. The results showed that compounds 6 and 7 exhibited promising inhibitory potency against the growth of two cell lines.
Asunto(s)
Basidiomycota/química , Indoles/aislamiento & purificación , Agaricales/química , Línea Celular Tumoral , Cuerpos Fructíferos de los Hongos/química , Humanos , Indoles/química , Isoindoles/química , Isoindoles/aislamiento & purificación , Estructura Molecular , Fenoles/química , Fenoles/aislamiento & purificaciónRESUMEN
Two new selaginellin derivatives selaginellin P (1) and selaginellin Q (2) were isolated from Selaginella tamariscina. The structures of 1 and 2 were established as 2,4'-dihydroxy-4-methyl-3-[(4-hydroxyphenyl)ethynyl]biphene (1) and 2,4'-dihydroxy-3-[(4-hydroxyphenyl)ethynyl]biphene (2) on the basis of spectroscopic means including HR-ESI-MS, 1D, and 2D NMR experiments.
