Dinámica mitocondrial: un potencial nuevo blanco terapéutico para la insuficiencia cardiaca / Mitochondrial dynamics: a potential new therapeutic target for heart failure

Las mitocondrias son organelos dinámicos, capaces de intercambiar su morfología entre redes elongadas e interconectadas y arreglos fragmentados y desconectados mediante los procesos de fusión y fisión mitocondrial, respectivamente. Estos eventos permiten la transmisión de moléculas de señalización y el intercambio de metabolitos dentro de la célula y participan en una amplia variedad de procesos biológicos, que incluyen el desarrollo embrionario, el metabolismo, la apoptosis y la autofagia. Aunque la mayoría de estos estudios se han realizado en células no cardiacas, la evidencia emergente indica que los cambios en la morfología mitocondrial participan en el desarrollo cardiaco, la respuesta al daño por isquemia-reperfusión, la insuficiencia cardiaca y la diabetes mellitus. En este artículo se revisa cómo la dinámica mitocondrial se altera en diversas enfermedades cardiacas, con especial énfasis en la insuficiencia cardiaca, y cómo este conocimiento podría proporcionar nuevos blancos terapéuticos para su tratamiento (AU)

Mitochondria are dynamic organelles able to vary their morphology between elongated interconnected mitochondrial networks and fragmented disconnected arrays, through events of mitochondrial fusion and fission, respectively. These events allow the transmission of signaling messengers and exchange of metabolites within the cell. They have also been implicated in a variety of biological processes including embryonic development, metabolism, apoptosis, and autophagy. Although the majority of these studies have been confined to noncardiac cells, emerging evidence suggests that changes in mitochondrial morphology could participate in cardiac development, the response to ischemia-reperfusion injury, heart failure, and diabetes mellitus. In this article, we review how the mitochondrial dynamics are altered in different cardiac pathologies, with special emphasis on heart failure, and how this knowledge may provide new therapeutic targets for treating cardiovascular diseases (AU)

[Mitochondrial dynamics: a potential new therapeutic target for heart failure]. / Dinámica mitocondrial: un potencial nuevo blanco terapéutico para la insuficiencia cardiaca.

Mitochondria are dynamic organelles able to vary their morphology between elongated interconnected mitochondrial networks and fragmented disconnected arrays, through events of mitochondrial fusion and fission, respectively. These events allow the transmission of signaling messengers and exchange of metabolites within the cell. They have also been implicated in a variety of biological processes including embryonic development, metabolism, apoptosis, and autophagy. Although the majority of these studies have been confined to noncardiac cells, emerging evidence suggests that changes in mitochondrial morphology could participate in cardiac development, the response to ischemia-reperfusion injury, heart failure, and diabetes mellitus. In this article, we review how the mitochondrial dynamics are altered in different cardiac pathologies, with special emphasis on heart failure, and how this knowledge may provide new therapeutic targets for treating cardiovascular diseases.