A Wireless Time-Scaling Chaotic Shift Keying Encryption System For Biosensing Systems.

This work presents a wireless time-scaling chaotic shift keying encryption system that can be used in wireless body area network applications. In wireless sensor nodes, the communication protocol being used provides some security measures and is implemented in software. However, no additional security measures are usually implemented. This paper demonstrates a discrete level real time encryption system using analog circuitry on a printed circuit board. The encryption system uses op amps, multipliers and resistors to implement the encryption. To implement wireless capabilities, commercial wireless microcontrollers using Bluetooth Low Energy were added, and a custom Bluetooth Low Energy profile was created to stream the analog encrypted signal.Clinical relevance- This work demonstrates an encryption system for wireless sensor devices for improved protection of private health information.

A Combined pH-Impedance System Suitable for Portable Continuous Sensing.

In this paper, a combined pH and impedance sensing system suitable for portable measurements is presented. The sensor outputs are converted directly to frequency or pulse width. The pH sensor is based on a voltage clamp topology that uses charging and discharging capacitors, voltage window comparators, and an SR-Latch to convert the output to frequency. The impedance to frequency sensor is based on current and voltage comparators and an SR-Latch. The pH system based on ISFET transistors is experimentally verified with on chip electrodes while the impedance sensor is characterized with discrete electronic components. The portable system is implemented with two chips and an external multi-electrode array into a portable system. Resistance, capacitance, and pH are experimentally measured using buffer solutions to simulate a water quality monitoring application. The system is implemented in a portable format and all modules, excluding the commercial microprocessor, consume an average power of 56 µW with an area of 0.006 mm 2 using a 180 nm technology.

A Wearable CMOS Impedance to Frequency Sensing System for Non-Invasive Impedance Measurements.

In this paper, we demonstrate a novel non-invasive, wearable impedance sensor. The impedance sensor, using an impedance to frequency measurement, with two modes of resistance and capacitance measurement is implemented in CMOS 130 nm technology. The sensor consisting of current and voltage comparators for different mode of measurement, has a low power consumption of 30 µW per channel. The sensor is demonstrated in two applications, thoracic impedance and hand gesture recognition. Thoracic impedance is based on impedance modulation through fluid accumulation. Hand gestures are detected through tissue impedance sensing. The full thoracic impedance sensing system is smaller than a credit card, low cost, and consumes 3 mW which includes the sensor, transmitter, and power control unit. Data received by this sensor can be easily transferred for further processing and, eventually, detection of heart failure. The electrodes were implemented using conductive paint, and the system was validated using passive loads to represent human tissue models and test subjects. The hand gesture system operates on 600  µW with the maximum number of electrodes, and uses adhesive copper with electrical paint as electrodes.

Wearables for the Next Pandemic.

This paper reviews the current state of the art in wearable sensors, including current challenges, that can alleviate the loads on hospitals and medical centers. During the COVID-19 Pandemic in 2020, healthcare systems were overwhelmed by people with mild to severe symptoms needing care. A careful study of pandemics and their symptoms in the past 100 years reveals common traits that should be monitored for managing the health and economic costs. Cheap, low power, and portable multi-modal-sensors that detect the common symptoms can be stockpiled and ready for the next pandemic. These sensors include temperature sensors for fever monitoring, pulse oximetry sensors for blood oxygen levels, impedance sensors for thoracic impedance, and other state sensors that can be integrated into a single system and connected to a smartphone or data center. Both research and commercial medically approved devices are reviewed with an emphasis on the electronics required to realize the sensing. The performance characteristics, such as accuracy, power, resolution, and size of each sensor modality are critically examined. A discussion of the characteristics, research challenges, and features of an ideal integrated wearable system is also presented.

CMOS based whole cell impedance sensing: Challenges and future outlook.

With the increasing need for multi-analyte point-of-care diagnosis devices, cell impedance measurement is a promising technique for integration with other sensing modalities. In this comprehensive review, the theory underlying cell impedance sensing, including the history, complementary metal-oxide-semiconductor (CMOS) based implementations, and applications are critically assessed. Whole cell impedance sensing, also known as electric cell-substrate impedance sensing (ECIS) or electrical impedance spectroscopy (EIS), is an approach for studying and diagnosing living cells in in-vitro and in-vivo environments. The technique is popular since it is label-free, non-invasive, and low cost when compared to standard biochemical assays. CMOS cell impedance measurement systems have been focused on expanding their applications to numerous aspects of biological, environmental, and food safety applications. This paper presents and evaluates circuit topologies for whole cell impedance measurement. The presented review compares several existing CMOS designs, including the classification, measurement speed, and sensitivity of varying topologies.