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15.
Science ; 291(5507): 1197, 2001 Feb 16.
Artículo en Inglés | MEDLINE | ID: mdl-11233438
19.
Sci Aging Knowledge Environ ; 2001(1): oa2, 2001 Oct 03.
Artículo en Inglés | MEDLINE | ID: mdl-14602946

RESUMEN

Alzheimer's disease (AD) afflicts 4 million people in the United States and is expected to strike 14 million by the year 2050, as the population ages. Researchers are scrambling to find genetic risk factors, decipher disease mechanisms, and develop reliable diagnostic tests that detect the illness at its earliest, potentially most treatable stage. Using these findings, they hope to devise new therapeutic approaches. Current clinical trials are testing novel techniques that stall or reverse AD-like neuropathology in mice.


Asunto(s)
Enfermedad de Alzheimer , Enfermedad de Alzheimer/diagnóstico , Enfermedad de Alzheimer/etiología , Enfermedad de Alzheimer/patología , Enfermedad de Alzheimer/terapia , Animales , Humanos
20.
Science ; 289(5482): 1123-5, 2000 Aug 18.
Artículo en Inglés | MEDLINE | ID: mdl-10970221

RESUMEN

The secret of the success of Mycobacterium tuberculosis, the pathogen that causes tuberculosis, is that it can linger undetected in the lungs for decades, hiding from the immune system's macrophages that aim to chew it up and spit it out. Now a team of researchers has uncovered a vulnerability in this resilient bug that suggests new ways to starve it out of its bolt-hole.


Asunto(s)
Isocitratoliasa/antagonistas & inhibidores , Macrófagos/microbiología , Mycobacterium tuberculosis/enzimología , Tuberculosis/microbiología , Animales , Antituberculosos/farmacología , Antituberculosos/uso terapéutico , Inhibidores Enzimáticos/farmacología , Inhibidores Enzimáticos/uso terapéutico , Glioxilatos/metabolismo , Isocitratoliasa/química , Isocitratoliasa/genética , Isocitratoliasa/metabolismo , Ratones , Mycobacterium tuberculosis/efectos de los fármacos , Mycobacterium tuberculosis/metabolismo , Tuberculosis/tratamiento farmacológico
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