Bisphosphonate-related osteonecrosis of the jaws: study of the staging system in a series of clinical cases.

OBJECTIVE: The aim of this study was to validate the classification of bisphosphonate-related osteonecrosis of the jaws (BRONJ) published in 2009(17) in a series of cases. MATERIAL AND METHODS: This retrospective clinical study included a series of 102 cases (81%) of intravenous BRONJ (iBRONJ, group 1) and 24 cases (19%) of oral BRONJ (oBRONJ, group 2). We recorded all patients' symptoms and clinical findings and classified each patient into a BRONJ stage (0-3; stage 0=non-exposed BRONJ). RESULTS: Most BRONJ cases (n=120, 95.2%) could be classified according to the proposed stages. Exposed necrotic areas of bone were more prevalent in group 1 than in group 2 (p<0.05). In contrast, we observed more BRONJ cases without areas of exposed bone in group 2 (n=12, 50%) than in group 1 (n=14, 13.7%; p<0.05). We could not assign six cases to any of the proposed stages. These cases had no areas of exposed necrotic bone, but had mandibular fractures, extra-oral fistula or affected maxillary sinuses. CONCLUSIONS: In our series, iBRONJ cases showed more advanced stages of BRONJ than did oBRONJ cases. We found few cases that could not be classified into any proposed stage because they had findings associated with stages 0 and 3 but lacked exposed necrotic bone.

Epidermal growth factor receptor copy number in potentially malignant oral disorders and oral squamous cell carcinoma: a short communication and preliminary study.

INTRODUCTION: This preliminary study compared the epidermal growth factor receptor (EGFR) copy number in patients with potentially malignant oral disorders (PMODs) and oral squamous cell carcinoma (OSCC). MATERIAL AND METHODS: Group 1 comprised 20 patients with oral leukoplakia and group 2 comprised 19 cases of OSCC. We estimated the EGFR copy number in both groups using real-time reverse-transcription polymerase chain reaction assays. We used laser microdissection (LMD) for EGFR amplification, and overexpression was performed. RESULTS: The EGFR copy number was higher in group 2 (9.1 ± 6.2) than in group 1 (3.8 ± 1.5). The greatest copy number was found in the non-homogeneous leukoplakias, but the difference in homogeneous cases was not significant (Mann-Whitney test, P>0.05). In group 2, the EGFR copy number was higher in advanced stages than in early stages, but again lacked statistical significance. CONCLUSIONS: The EGFR copy number may be a useful biomolecular marker to differentiate PMODs from OSCC. The EGFR was higher in non-homogeneous leukoplakias and in the advanced stages of OSCC.

Sarcoma miofibroblástico cervical: extirpación quirúrgica y reconstrucción con colgajo supraclavicular pediculado en isla / Myofibroblastic sarcoma of the neck: surgical excision and reconstruction with fasciocutaneous supraclavicular artery island flap

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Assessment of quality of life in oral cancer.

Quality of life (QL) in oral cancer patients has become one of the most important parameters to consider in the diagnosis and post-treatment follow-up. The purpose of this article has been to review the papers published that study the QL in oral cancer patients, the different QL questionnaires used, the clinical results obtained, and the systematic revisions available in the indexed literature for the last 10 years. The term QL appears as a keyword in an increasing number of articles throughout the past 10 years; however, few studies focus on oral cancer. Most of them assess all head and neck cancers, which conform to a heterogeneous group with several different features depending on location (oral cavity, oropharynx, larynx, hypopharynx, nasopharynx and salivary glands). Most studies evaluate QL in short periods of time, normally within the first year after the diagnosis. Series do not discern between different therapeutic options, and they generally center on Northern European or Northern American populations. There are few instruments translated and validated into Spanish that measure QL, a fundamental characteristic to link QL to own patients' socio-cultural parameters. Data related with QL are mostly related to patient (age, sex, co-morbidity), tumour (location, size), and treatment (surgical treatment, radiotherapy association, reconstruction, cervical dissection, and/or feeding tube). Nowadays QL's assessment is considered an essential component of an oral cancer patient as well as the survival, morbidity and years free of disease. Although many aspects related to QL in oral cancer patients have been published throughout the past 10 years, more systematic research is needed to be able to apply it on a daily basis.

Assessment of quality of life in oral cancer

Quality of life (QL) in oral cancer patients has become one of the most important parameters to consider in thediagnosis and post-treatment follow-up. The purpose of this article has been to review the papers published that studythe QL in oral cancer patients, the different QL questionnaires used, the clinical results obtained, and the systematicrevisions available in the indexed literature for the last 10 years.The term QL appears as a keyword in an increasing number of articles throughout the past 10 years; however, fewstudies focus on oral cancer. Most of them assess all head and neck cancers, which conform to a heterogeneous groupwith several different features depending on location (oral cavity, oropharynx, larynx, hypopharynx, nasopharynx andsalivary glands). Most studies evaluate QL in short periods of time, normally within the first year after the diagnosis.Series do not discern between different therapeutic options, and they generally center on Northern European orNorthern American populations. There are few instruments translated and validated into Spanish that measure QL,a fundamental characteristic to link QL to own patients’ socio-cultural parameters. Data related with QL are mostlyrelated to patient (age, sex, co-morbidity), tumour (location, size), and treatment (surgical treatment, radiotherapyassociation, reconstruction, cervical dissection, and/or feeding tube). Nowadays QL’s assessment is considered anessential component of an oral cancer patient as well as the survival, morbidity and years free of disease. Althoughmany aspects related to QL in oral cancer patients have been published throughout the past 10 years, more systematicresearch is needed to be able to apply it on a daily basis (AU)