RESUMEN
Microorganisms, such as yeasts, filamentous fungi, bacteria, and microalgae, have gained significant attention due to their potential in producing commercially valuable natural carotenoids. In recent years, Phaffia rhodozyma yeasts have emerged as intriguing non-conventional sources of carotenoids, particularly astaxanthin and ß-carotene. However, the shift from academic exploration to effective industrial implementation has been challenging to achieve. This study aims to bridge this gap by assessing various scenarios for carotenoid production and recovery. It explores the use of ionic liquids (ILs) and bio-based solvents (ethanol) to ensure safe extraction. The evaluation includes a comprehensive analysis involving Life Cycle Assessment (LCA), biocompatibility assessment, and Techno-Economic Analysis (TEA) of two integrated technologies that utilize choline-based ILs and ethanol (EtOH) for astaxanthin (+ß-carotene) recovery from P. rhodozyma cells. This work evaluates the potential sustainability of integrating these alternative solvents within a yeast-based bioeconomy.
Asunto(s)
Basidiomycota , beta Caroteno , Saccharomyces cerevisiae , Carotenoides , Etanol , Solventes , XantófilasRESUMEN
ABSTRACT Natural latex from Hevea brasiliensis (Wild. ex A.Juss) Müll.Arg., Euphorbiaceae, showed angiogenic action and Casearia sylvestris Sw., Salicaceae, leaf derivatives presented anti-inflammatory and wound healing activities. Therefore, an association of these effects was interesting for wound healing applications. The aims of this study were the development of membranes of natural latex incorporated with C. sylvestris leaf derivatives (ethanolic extract, diterpene concentrated fraction and casearin J), their chemical and physical characterization, and the evaluation of in vitro skin permeation and retention of C. sylvestris bioactive secondary metabolites (diterpenes and phenolic compounds). The membranes were developed mixing hydroethanolic solutions of C. sylvestris derivatives with latex and drying them in a desiccator. They were characterized by infrared spectroscopy, scanning electron microscopy, water vapor permeability and mechanical resistance assays, demonstrating that all membranes were permeable, resistant and homogeneous in surfaces. The permeation and retention assays demonstrated dermal penetration of phenolic compounds for ethanolic extract membrane and of casearin-like clerodane diterpenes for all membranes, indicating that these membranes have great potential for therapeutical application as a topical system for C. sylvestris components releasing.
RESUMEN
Objetivo: O objetivo do presente trabalho foi analisar/quantificar a produtividade científica dos docentes pertencentes à Universidade Estadual Paulista (UNESP), campus de Assis/SP. Métodos: A coleta de dados foi realizada por meio de busca na Internet, entre janeiro e fevereiro de 2011. Para cada professor, analisamos o número total de artigos (na plataforma Lattes), no ISI Web of Science, no SCOPUS, os livros e/ou capítulos de livros publicados e as orientações em Programas de Pós-Graduação (PPG). A análise dos dados foi feita utilizando a ANOVA, o Kruskall-Wallis e o Post Hoc (Bonferrroni). Resultados: A análise dos dados demonstrou que dos nove departamentos da Faculdade de Ciênciase Letras (FCLAs) as médias mais altas (P < 0,05) de artigos na Plataforma Lattes foi obtido peloDepartamento de Literatura. O resultado mais baixo foi encontrado no Departamento de Letras Modernas. O Departamento de Ciências Biológicas apresentou médias mais altas (P < 0,05) de artigos indexados no ISI/SCOPUS do que os outros oito departamentos. Com o intuito de diminuir as particularidades das áreas de pesquisa, empregamos uma análise na quantidade de livros e capítulos publicados, pois são formas de divulgação muito utilizadas na área de ciências humanas e sociais. Já em relação à Pós-Graduação, os programas de História e Letras dos departamentos de História e Literatura foram o que apresentaram maiores médias (P < 0,05) de orientações em andamento e/ou concluídas em relação aos outros programas. Conclusão: O presente estudo demonstrou disparidade entre os itens analisados nos departamentos e programas de pós-graduação da UNESP, campus de Assis. Esses resultados podem estar associados às características do campo da concentração e da cobertura limitada do banco de dados ISI eSCOPUS.
In this work, we analyzed the scientific bibliographic productivity of the Faculdade Ciências e Letras deAssis, Universidade Estadual Paulista (FCLAs-UNESP). We evaluated the scientific productivity of Professors using data retrieved from the Lattes Plataform database (Curriculum Lattes), ISI Web of Science and SCOPUS, books published, chapter of the books published and academic advisory (Masters Thesisand Ph.D. Thesis). Bibliometric evaluations of departments showed a better performance of the total number of papers (indexed in Curriculum Lattes database) by Literature Department (P < 0.05) when compared to Modern Languages Department. The Biological Sciences Department had means higher of the papers indexed by SCOPUS (P < 0.05) and ISI (P < 0.05) when compared to others departments. We also observed that the low h-indexes (P< 0,05) in the humanities areas is result of traditional mode of communication in this area of knowledge, which makes more use of books and proceedings of meetings when compared to natural sciences. These publications are not covered by ISI and SCOPUS. The graduate programs in History and Languages presented means higher of academic advisory (Masters Thesis and Ph.D. Thesis) because are graduate programs consolidated in the 1970s.
Asunto(s)
Bibliometría , Publicaciones de Divulgación Científica , Indicadores de Producción CientíficaRESUMEN
O objetivo do presente trabalho foi analisar/quantificar a produtividade cientifica dos docentes pertencentes à Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo (FFCLRP-USP) vinculados aos oito cursos de graduação e seis programas de pós-graduação. Métodos: Os índices analisados para cada professor foram: 1) número total de artigos (na plataforma Lattes), 2) número de artigos indexados pela Thomson ISI Web ofScience, e 3) o índice-h. Aplicamos os testes ANOVA, Kruskall-Wallis e o Post Hoc (Bonferrroni) para identificar possíveis diferenças entre os cursos de graduação e os programas de pósgraduação.
In this work, an analysis of scientific bibliographic productivity was made using the Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo (FFCLRPUSP) as example. It is a special Institution in the Brazilian University system which encompasses four important areas of knowledge (fields of concentration) in natural, biological, humanities, and social areas. It is composed by four departments which offer altogether eight undergraduate courses:1) Psychology, 2) Pedagogy, 3) Chemistry, 4) Biology, 5) Medical Physics, 6) Biomedical Informatics,7) Sciences of Information and Documentation and 8) Mathematics Applied to Business and sixgraduate programs leading to M.S. and Ph.D. degrees. Moreover, when analyzing the different courses of FFCLRP, they represent typical academic organization in Brazil and Latin America and could be taken as a model for analyzing other Brazilian research institutions.