Role of human adipose-derived stem cells (hADSC) on TGF-ß1, type I collagen, and fibrosis degree in bladder obstruction model of Wistar rats.

INTRODUCTION: Bladder outlet obstruction (BOO) was caused by a series of histological and biochemical changes in the bladder wall, through the inflammation process in the bladder wall, hypertrophy and fibrosis. ADSC has an important role in bladder regeneration. METHODS AND MATERIALS: This study was an experimental randomized study using male Wistar rats which were monitored at 2 and 4 weeks to determine the effect of ADSC therapy on TGF-ß1 type I collagen, and degree of fibrosis. RESULT: Rats were divided into 5 groups. In the week 2 BOO group, 1 sample included in the category of moderate fibrosis, 1 sample that was given ADSC with mild fibrosis category, 3 samples included in severe fibrosis category, 3 samples that were given ADSC included in the category of moderate fibrosis. The concentration of TGF-ß1 in the hADSC therapy group was significantly lower than the control group at the 2nd and 4th week of monitoring (p2 = 0.048, p4 = 0.048), and also with more type I collagen on 2nd and the 4th week (p2 = 0.048, p4 = 0.048). CONCLUSION: ADSC therapy can reduce the concentration of TGF-ß1, type I collagen, and degree of fibrosis in the male Wistar BOO model.

Reno-duodenal fistula as a rare complication of percutaneous nephrostomy: A case report.

Renoduodenal fistula is a rare condition where a pathological tract is formed between the kidney and duodenum. This condition is caused by various etiologies, such as tuberculosis, malignancy, percutaneous nephrostomy procedure, cryoablation procedure in malignancy, and chronic infection. In this case, we report a case renoduodenal fistula caused by large staghorn calculus, precipitated by a previous history of trauma. Renoduodenal fistula is a rare condition that often presents without symptoms. This condition can be caused by chronic infection of the kidney, and one of the etiology is an infected large staghorn calculus.