1.
Angew Chem Int Ed Engl
; 37(19): 2661-2663, 1998 Oct 16.
Artículo
en Inglés
| MEDLINE
| ID: mdl-29711622
RESUMEN
The biomimetic synthesis of a pentacyclic alkaloid (keramaphidin B, 1), an intermediate in the biogenetic pathway to the manzamine alkaloids, has been achieved. Compound 1 was formed by an intramolecular Diels-Alder reaction of macrocycle 2 in buffer followed by reduction with NaBH4 . This reaction provides the first direct expeimental evidence for the authors' biosynthetic hypothesis.