Green preparation of new pyrimidine triazole derivatives via one-pot multicomponent reactions of guanidine.

In this research the goal was to produce novel pyrimidine triazole compounds in high yields using triethylamin as an efficient catalyst. These new compounds were synthesized by using multicomponent reaction of aldehydes, guanidine, electron deficient acetylenic compounds, tert-butyl isocyanide and hydrazonoyle chloride in aqueous media. Due to the presence of an NH group, which was assessed using two different methodologies, newly synthesized pyrimidine triazoles have antioxidant properties. Additionally, the antibacterial activity of newly created pyrimidine triazoles was assessed using the disk distribution method with two different types of Gram-positive bacteria and Gram-negative bacteria, demonstrating that the use of these compounds prevented the growth of bacteria. Applied to the preparation of pyrimidine triazole derivatives, this method has short reaction times, high product yields, and the ability to separate catalyst and product using simple procedures.

Solvent-free synthesis of new spiropyrroloindole compounds using Fe3O4/TiO2/MWCNTs MNCs via multicomponent reactions: assessment of new spiropyrroloindole antioxidant activity.

In this study, water extract of Spinacia oleracea leaves was used for the synthesis of Fe3O4/TiO2/MWCNTs magnetic nanocomposites and high performance of this catalyst was confirmed by employing it in the solvent-free multicomponent reactions of anilines, oxalyl chloride, diamines or hydroxyamines, electron-deficient acetylenic ester, α-haloketones and Et3N at room temperature for the generation of new spiropyrroloindoles in high yields. This catalyst could be utilized several times and has a significant role in the yield of product. The synthesized spiropyrroloindoles have NH and OH group in their structure and for this reason have good antioxidant activity. Also, by employing Gram-positive and Gram-negative bacteria and the disk diffusion procedure confirmed the antimicrobial effect of some spiropyrroloindole derivatives. The results showed that synthesized spiropyrroloindoles prevented the bacterial growth. This used process for preparation of new spiropyrroloindoles has some improvements such as low reaction time, product with high yields, and simple separation of catalyst and products.