RESUMEN
Blood coagulation and fibrinolysis before and after splenectomy was studied in 74 cases of liver cirrhosis. A hypocoagulable state was found before splenectomy, but the platelet count, and the levels of fibrinogen, plasminogen, ±2-macroglobulin and antithrombin III increased significantly after splenectomy (p < 0.05 to p < 0.001). A marked improvement was observed on the values of r (reaction time), k (clot formation time) and ma (maximal amplitude) of thrombelastograms (p < 0.05 to p < 0.001). The prothrombin time was reduced after the surgery, but not significantly (0.05 < p < 0.1). The levels of arantitrypsin remained almost unchanged, while serum fibrinogen-fibrin degradation products (FDP) showed a slight decrease postoperatively.The immunohistologic study of the spleen excised from 7 cases with liver cirrhosis, with the use of the direct immunofluorescence technique, demonstrated the deposits of fibrin in the splenic cords in all cases. It was not recognized in the spleens of 4 cases without cirrhosis used as the control.A further study of the spleen weight and plasma fibrinogen level showed that a significant inverse correlation exists between these two parameters (p < 0.01).These findings suggest that localized intravascular coagulation (LIC) occurs in the enlarged spleen associated with liver cirrhosis.