Asunto(s)
Trasplante de Riñón/efectos adversos , Riñón/diagnóstico por imagen , Radiofármacos , Tecnecio Tc 99m Mertiatida , Ureterostomía/métodos , Reservorios Urinarios Continentes , Falla de Equipo , Humanos , Riñón/patología , Masculino , Persona de Mediana Edad , Cintigrafía , Factores de Tiempo , Incontinencia UrinariaAsunto(s)
Hemorragia/etiología , Arteria Hepática/lesiones , Hígado/lesiones , Traumatismo Múltiple/diagnóstico , Heridas por Arma de Fuego/diagnóstico , Adulto , Implantación de Prótesis Vascular , Colangiopancreatografia Retrógrada Endoscópica , Conducto Colédoco/lesiones , Conducto Colédoco/cirugía , Embolización Terapéutica , Urgencias Médicas , Extravasación de Materiales Terapéuticos y Diagnósticos , Hemorragia/diagnóstico , Hemorragia/terapia , Arteria Hepática/cirugía , Humanos , Masculino , Traumatismo Múltiple/terapia , Intensificación de Imagen Radiográfica , Stents , Tomografía Computarizada por Rayos X , Heridas por Arma de Fuego/terapiaRESUMEN
BACKGROUND: The aim of the study was to determine the value of radioisotope bone scans in the preoperative staging of patients with hepatopancreatobiliary (HPB) cancer. METHODS: Bone scanning was performed as part of a routine staging protocol in 402 consecutive patients with HPB cancer over a period of 5 years. Patients with positive bone scans underwent coned radiography, computed tomography with review on bone windows, or a bone biopsy. Bone scans were reviewed along with staging investigations, surgical and histological findings. Patients were followed for a minimum of 6 months. RESULTS: There were 171 patients with colorectal liver metastases, 106 with suspected pancreatic cancer, 47 with hepatocellular cancer, 52 with gallbladder cancer or cholangiocarcinoma, and 26 with other types of HPB cancer. Bone scans were negative in 377 patients (93.8 per cent) and positive in 25 patients (6.2 per cent). Of the 25 positive scans, 16 were falsely positive as a result of degenerative bone disease. Of nine patients with a true-positive bone scan, four had locally irresectable disease and four distant metastases. In only one patient did the bone scan result alone influence the decision to resect the HPB cancer. Overall sensitivity was 100 per cent, specificity 95.9 per cent, positive predictive value 36.0 per cent and negative predictive value 100 per cent. CONCLUSION: Bone scanning should not be included in the routine staging protocol for HPB cancer.
Asunto(s)
Neoplasias Óseas/diagnóstico por imagen , Colangiocarcinoma/patología , Neoplasias Colorrectales/patología , Neoplasias de la Vesícula Biliar/patología , Neoplasias Hepáticas/patología , Neoplasias Pancreáticas/patología , Anciano , Biopsia con Aguja/métodos , Neoplasias Óseas/secundario , Femenino , Humanos , Imagen por Resonancia Magnética/métodos , Masculino , Persona de Mediana Edad , Estadificación de Neoplasias/métodos , Cuidados Preoperatorios/métodos , Estudios Prospectivos , Radiofármacos , Sensibilidad y Especificidad , Medronato de Tecnecio Tc 99m , Tomografía Computarizada de Emisión/métodos , Tomografía Computarizada Espiral/métodosAsunto(s)
Trastornos de Deglución/complicaciones , Neumonía por Aspiración/diagnóstico por imagen , Trastornos de Deglución/diagnóstico por imagen , Trastornos de Deglución/cirugía , Gastrostomía , Humanos , Masculino , Persona de Mediana Edad , Cooperación del Paciente , Neumonía por Aspiración/etiología , Periodo Posprandial , Cintigrafía/métodosAsunto(s)
Fluorodesoxiglucosa F18 , Vacunas contra la Influenza/farmacología , Ganglios Linfáticos/diagnóstico por imagen , Tomografía Computarizada de Emisión/estadística & datos numéricos , Adulto , Animales , Axila , Diagnóstico Diferencial , Reacciones Falso Positivas , Femenino , Humanos , Vacunas contra la Influenza/inmunología , Gripe Humana/inmunología , Gripe Humana/prevención & control , Ganglios Linfáticos/inmunología , Metástasis Linfática/diagnóstico por imagen , Metástasis Linfática/inmunología , Activación de Linfocitos/efectos de los fármacos , Activación de Linfocitos/inmunología , Ratones , Modelos AnimalesAsunto(s)
Radioisótopos de Cromo/sangre , Ácido Edético/sangre , Tasa de Filtración Glomerular , Radioisótopos de Cromo/farmacocinética , Radioisótopos de Cromo/orina , Ácido Edético/farmacocinética , Ácido Edético/orina , Humanos , Pruebas de Función Renal , Tasa de Depuración Metabólica , Radiofármacos/sangre , Radiofármacos/farmacocinética , Radiofármacos/orina , Reproducibilidad de los Resultados , Albúmina SéricaRESUMEN
OBJECTIVES: Although it only occurs in a minority of patients, renal involvement is a life-threatening complication of scleroderma (SSc). We have investigated the utility of two formulae to calculate glomerular filtration rate (GFR) in a population of SSc patients. METHODS: Twenty-six patients (20 female, 6 male, median age 58 yr, age range 12-80 yr) satisfied our criteria for inclusion in a retrospective comparison of measured and calculated GFR. GFR was measured using (51)Cr-EDTA. The modified Cockcroft and Gault formula and equation 7 from the Modification of Diet in Renal Disease (MDRD) were used to calculate GFR. RESULTS: Eighteen out of 19 patients analysed with a serum creatinine concentration less than the upper limit of the normal range had a measured GFR outside the normal range. Three patients with a normal creatinine concentration had a measured GFR <60 ml/min and in each of these the calculated GFR was also abnormal. All patients with a measured GFR <60 ml/min were identified using both the MDRD and the modified Cockcroft and Gault formula to calculate GFR. The greatest correlation between measured and calculated GFR was seen when the MDRD formula, which employs demographic and serum variables, was used in patients with body surface area (BSA) >1.4 m(2) who were not taking Iloprost (r=0.91). Use of the Cockcroft and Gault formula to calculate creatinine clearance with a correction factor for GFR, the inclusion of patients taking Iloprost and the inclusion of patients with BSA <1.4 m(2) were all associated with a lower degree of correlation. CONCLUSION: Serum creatinine is a poor marker of renal function in SSc patients. Calculating GFR from demographic and serum variables is a simple technique to identify SSc patients who have abnormal renal function. The authors recommend the use of the MDRD formula.