Exercise improves depression through positive modulation of brain-derived neurotrophic factor (BDNF). A review based on 100 manuscripts over 20 years.

The aim of this review was to explore the relevant neurobiology and the association between peripheral levels of brain-derived neurotrophic factor (BDNF) and acute and short to long-term exercise regimes, as well as its relation to depression and antidepressant treatment. A 20-year literature search was conducted. The screening process resulted in 100 manuscripts. Antidepressants as well as acute exercise, particularly high-intensity, elevates BDNF in healthy humans and clinical populations, as evidenced from aerobic and resistance-based studies. Although exercise is increasingly recognised in the management of depression, acute and short-term exercise studies have failed to establish a relationship between the severity of depression and changes in peripheral BDNF. The latter rapidly returns to baseline, possibly indicating a quick re-uptake by the brain, aiding its neuroplasticity functions. The timescale of administration needed for the antidepressants to stimulate biochemical changes is longer than similar increases with acute exercise.

The Impact of the Proposed Changes for the DSM-5 on Diagnoses of First-time DUI/DWI Offenders.

Driving while impaired (DWI) is a frequently committed crime with enormous individual and social costs. The type of disposition and/or treatment appropriate for an individual offender is often determined, in part, by diagnostic criteria based on the American Psychiatric Association's Diagnostic and Statistics Manual. The DSM-5 significantly modified these criteria by eliminating legal problems as a criterion and dropping the categories of abuse and dependence. A brief substance abuse focused interview was conducted with 658 consecutive first-time DUI offenders who were arrested for driving under the influence of alcohol. Most were white, well-educated males. Contingency analyses were utilized to compare the current with the new diagnostic criteria based on algorithms for both diagnostic formulations. The major change observed when moving from DSM-IV-TR to DSM-5 criteria was that, approximately 54% of first-time DUI/DWI offenders would no longer meet diagnostic criteria based on the DSM-5. Of the nearly 17% who met dependence criteria, the majority were in the severe designation of the DSM-5.