[SAFETY OF INFLUENZA VACCINATION IN CHILDREN WITH SEVERE ALLERGY TO HEN'S EGGS: A PROSPECTIVE CASE SERIES STUDY].

BACKGROUND: Influenza vaccination guidelines have recommended that pediatricians should consult with allergists in the case of for children with histories of anaphylaxis to hen's eggs. On the other hand, whether such children can be safely vaccinated is unclear. OBJECTIVE: To evaluate the safety of influenza vaccination for children severely allergic to eggs. METHODS: The study population consisted severe egg-allergic children that had never been immunized with influenza vaccine. The inclusion criteria of severe egg-allergic children included evidence of serum specific IgE antibodies to egg white or an ovomucoid level of class4 or more and complete elimination of dietary intake of eggs, or occurrence of Sampson Grade 3 to 5 anaphylactic reactions upon egg ingestion. Patients underwent skin prick tests, and received 0.1ml of influenza vaccine, followed in 30 minutes if no reaction with the remainder of an age-appropriate dose. We observed the subjects for 30 minutes afterwards, and they were observed by their patients during the subsequent 24 hours. RESULTS: A total of 17 patients were enrolled. All patients received influenza vaccination without an allergic reaction. CONCLUSIONS: Influenza vaccination is safe even in children with histories of severe egg allergy. influenza vaccination without an allergic reaction.

[Effects of measurement position on the forced oscillation technique values].

BACKGROUND: Cheek support and subject's arm position can influence on lung function values measured with forced oscillation technique. We examined resistance and reactance by different methods using a new forced oscillation technique machine called MostGraph (Chest Co. Ltd., Tokyo, Japan). METHODS: We evaluated nineteen adults. Four methods are measured. 1: the subjects support their cheeks with their hands. 2: the tester support the subject's cheeks with their hands. 3: the subjects stiffen their cheeks without any cheek support. 4: subject relax their cheeks without any cheek support. R5, R20, R5-R20, X5, Fres and ALX were compared between four methods. RESULTS: In resistance values, R20 was the lowest in the fourth method, and it was significantly different from the first (p<0.01) and the second (p<0.01) method. R5-R20 was the lowest in the second method, and it was significantly different from the third (p<0.01) and forth (p<0.01) methods. In reactance values, X5 was the highest in the second method. All ractance values in the second method were significantly different from the first and the fourth method. CONCLUSION: Measurement values using Mostgraph was influenced by methods of supporting cheeks and subject's arm position. Measurement method should be unify and the first method is ideal and practical.

[The evaluation of lung function by using forced oscillation technique for children with asthma].

BACKGROUND: Lung function measurements are useful objective indices to monitor asthma control in children. Recently, a new forced oscillation technique machine called MostGraph (Chest Co. Ltd., Tokyo, Japan) has been developed to diagnose and monitor asthma. We assessed the utility of MostGraph in asthmatic children. METHODS: We evaluated 66 well controlled asthmatic children (11±3 yrs). For each subject, we measured respiratory function using MostGraph and spirometry and assessed the relationship between the two indices. RESULTS: MostGraph measurements were significantly correlated with age and body height. R5 was remarkably associated with FEV1% by analyzing partial correlation that excluded the factor of height. In addition, R5-R20 and Fres were significantly related to FEV1% and MMF. Furthermore, R5-R20 and Fres were significantly associated with MMF through multiple regression analyses for MostGraph parameters, the height and spirometory parameters. We classified asthmatic children into two groups with 70% of V25 cut point. Group with V25 below 70% had higher scores for R5-R20, Fres and ALX, compared to group with V25 above 70%. CONCLUSION: MostGraph could be effectively used for the R5-R20 and Fres lung function measurements to assess asthma control in children. The results also suggested that R5-R20 and Fres might be parameters of small airway dysfunction.