Effects of Probiotic Supplementation during Chronic Rhinosinusitis on the Microbiome.

Probiotics are live microorganisms that induce health benefits to the host. The consumption of probiotics can result in both prophylactic and therapeutic effects. Chronic rhinosinusitis (CRS) is an inflammatory condition that has a significant health and economic impact worldwide. Despite its great burden on the health-care system and patients' quality of life, the variety of therapy options for CRS is currently limited. Inflammation, mucociliary dysfunction and changes in the microbial environment are thought to be the main factors causing the disease. Probiotics are a relatively new intervention, with a focus on the probiotic qualities and adaptive elements required for a bacterial strain to have a positive impact on CRS. The aim of this review was to review studies evaluating the potential beneficial effects of probiotics in the treatment of chronic rhinosinusitis. Future prospects and difficulties for probiotics in CRS are also highlighted.

Paranasal sinus disease could be a reason for unsuccessful immunotherapy of inhalant allergy in children.

PURPOSE: The aim of this study was to evaluate the role of paranasal sinuses condition assessed in computed tomography on inhalant allergen desensitization effects. MATERIALS & METHODS: Retrospective analysis of medical records of children undergoing allergen immunotherapy in outpatient otolaryngology clinic of University Children Hospital in Lublin was performed. Control group consisted of children who underwent allergen immunotherapy and obtained satisfying effects; study group consisted of children who did not experience significant improvement after desensitization therapy. RESULTS: Computed tomography of nose cavity and paranasal sinuses exposed numerous pathologic changes affecting both, control and study group. Blockage of ostiomeatal complex was twice more common in children who did not respond adequately to desensitization therapy. In our study group, radiological findings suggesting rhinosinusitis were found in 73% of patients, while retention cysts in maxillary sinuses were discovered in 27% of patients. CONCLUSIONS: Pathological findings in paranasal sinuses in computed tomography may arise from uncontrolled allergic rhinitis. If chirurgical management is indicated, allergen immunotherapy should be postponed until total recovery from operational procedure and repeated.

[Evaluation of osteomeatal complex in children with chronic sinusitis]. / Ocena kompleksu ujsciowo-przewodowego w przewleklych zapaleniach zatok przynosowych u dzieci.

The aim of this publication was estimation of osteomeatal complex and its visualisation by means of CT in children having been treated conservatively and surgically because of sinusitis. There were analyzed 47 children age 4 to 18 years who had been treated in Dept. of Children Otolaryngology, Phoniatry and Audiology of Medical University in Lublin during 2001-2005. It was found, that the causes of sinusitis are disturbances of osteomeatal complex and that the frontal projection in CT investigation is more efficient in preoperative diagnostics than sagittal projection.